Blar i Institutt for kjemi på forfatter "Bakka, Thomas Aleksander"
-
Methyl propiolate and 3-butynone: starting points for synthesis of amphiphilic 1,2,3-triazole peptidomimetics for antimicrobial evaluation
Bakka, Thomas Aleksander; Strøm, Morten B.; Andersen, Jeanette hammer; Gautun, Odd Reidar (Journal article; Peer reviewed, 2017)A library of 29 small 1,4-substituted 1,2,3-triazoles was prepared for studies of antimicrobial activity. The pharmacophore model investigated with these substrates was based on small peptidomimetics of antimicrobial ... -
Regioselective Preparation of 1,2,3-Triazoles for Bioactive Studies Based on Marine Bioprospecting
Hansen, Ole Kudsk (Master thesis, 2015)The azides 1d and 1c were prepared using literature procedures. The azides serve as starting materials in copper- and ruthenium-catalyzed 1,3-dipolar dipolar cycloadditions to N-protected alkynes 2a and 2b, to afford ... -
Simple generalized reaction conditions for the conversion of primary aliphatic amines to surfactant-like guanidine salts with 1H-pyrazole carboxamidine hydrochloride
Bakka, Thomas Aleksander; Gautun, Odd Reidar (Journal article, 2017)Improved reaction conditions for the electrophile reaction between a free aliphatic amine and 1H-pyrazole carboxamidine have been discovered. The surfactant-like guanidine salts, which are often hard to work with, were ... -
Synthesis and antimicrobial evaluation of cationic low molecular weight amphipathic 1,2,3-triazoles
Bakka, Thomas Aleksander; Strøm, Morten B.; Andersen, Jeanette hammer; Gautun, Odd Reidar (Journal article; Peer reviewed, 2017)A library of 28 small cationic 1,4-substituted 1,2,3-triazoles was prepared for studies of antimicrobial activity. The structures addressed the pharmacophore model of small antimicrobial peptides and an amphipathic motif ... -
Synthesis and Antimicrobial Evaluation of Small Molecule Amphiphiles Derived from Amphiphilic Antimicrobial Natural Products
Bakka, Thomas Aleksander (Doctoral theses at NTNU;2017:239, Doctoral thesis, 2017)Development of antimicrobial agents that work through novel mechanisms is of importance for combating the steadily increasing proliferation of resistant bacteria. Infections caused by resistant bacteria have become an ... -
Synthesis and Mechanistic Studies of Optically Active Tartaric Acid Based Surfactants
Bakka, Thomas Aleksander (Master thesis, 2013)Gaining knowledge of the isomerization mechanisms are of pivotal importance for stereochemically pure synthesis. Optically pure tartaric acid based surfactants are seen as important precursors for optically active ...