Browsing Institutt for kjemi by Title
Now showing items 186-205 of 1358
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Chemo-Enzymatic Synthesis of Enantiopure β-Antagonist (S)-Betaxolol
(Peer reviewed; Journal article, 2022)The β-blocker (S)-betaxolol has been synthesized in 99% enantiomeric excess (ee) from the commercially available precursor 4-(2-hydroxyethyl)phenol. The racemic chlorohydrin 1-chloro-3-(4-(2-(cyclopropylmethoxy)ethyl)phe ... -
Chemo-enzymatic synthesis of fluorinated carbohydrate derivatives
(Doktoravhandlinger ved NTNU, 1503-8181; 2011:162, Doctoral thesis, 2011)The enzymatic hydrolysis of the benzoylated methyl pyranosides has been investigated using Candida rugosa lipase (CRL) as a catalyst. Hydrolyses of all substrates proceeded in a regiospecific manner at C-6. No acyl migration ... -
Chemoenzymatic Protocol for the Synthesis of Enantiopure β-Blocker (S)-Bisoprolol
(Peer reviewed; Journal article, 2023)The β-blocker (S)-bisoprolol hemifumarate has been synthesised in 96% enantiomeric excess with 19% total yield in a six-step synthesis. A transesterification reaction of the racemic chlorohydrin 1-chloro-3-(4-((2-isoprop ... -
Chemoenzymatic synthesis of (S)-carteolol: Kinetic resolution by transesterification of precursors with Candida antarctica Lipase B
(Master thesis, 2021)Det har vært et økt fokus på syntese av enantiomert rene aktive farmasøytiske ingredienser de siste tiårene. Kombinert med et økende behov for miljøvennlig kjemi så er det av stor interesse å utforske biokatalytisk syntese ... -
Chemoenzymatic synthesis of enantiopure beta blockers (R)-sotalol, (S)-penbutolol and (S)-bisoprolol
(Master thesis, 2022)Beta blockers are medications used to reduce blood pressure. In commercial beta blockers, the active pharmaceutical ingredient (API) is always a chiral molecule, and is usually present as a racemic mixture. Usually, one ... -
Chemoenzymatic Synthesis of Synthons as Percursors for Enantiopure Clenbuterol and Other β2-Agonists
(Journal article; Peer reviewed, 2018)Clenbuterol is a β2-agonist used in the veterinary treatment of asthma in several countries. The drug is listed on the World Antidoping Agency’s prohibited list due to its effect on increased protein synthesis in the body. ... -
Choice of Liquid Electrolytes In Anode Free Lithium Metal Batteries and its Impact on Lithium Morphology
(Bachelor thesis, 2022)En økning i etterspørser for energitette batterier fra elektriske kjøretøy har gitt insentiv for å utvikle ny teknologi for energitett lagring av elektrisitet. En teknologi som har muligheten til å fylle etterspørselen er ... -
Choked liquid flow in nozzles: crossover from heterogeneous to homogeneous cavitation and insensitivity to depressurization rate
(Peer reviewed; Journal article, 2021)The critical mass flow rate is the maximum flow rate that can pass through a constrained geometry such as a nozzle. For liquid CO2, it has been shown that homogeneous relaxation models systematically underpredict the ... -
Circulating trace elements: Comparison between early and late incubation in common eiders (Somateria mollissima) in the central Baltic Sea
(Peer reviewed; Journal article, 2020)We analyzed body mass and a panel of 64 trace elements in blood from incubating common eiders (Somateria mollissima) in the central Baltic Sea during the breeding seasons of 2017 (n = 27) and 2018 (n = 23). Using a ... -
Classical density functional theory for interfacial properties of hydrogen, helium, deuterium, neon and their mixtures
(Peer reviewed; Journal article, 2023)The DFT is developed to study the interfacial properties of hydrogen, helium, neon, deuterium and their mixtures, i.e. fluids that are strongly influenced by quantum effects at low temperatures. White Bear fundamental ... -
Climate change mitigation effects: How do potential CO2 leaks from a sub-seabed storage site in the Norwegian Sea affect Astarte sp. bivalves?
(Peer reviewed; Journal article, 2021)Carbon capture and storage (CCS) is one of the most promising mitigation strategies for reducing the emissions of carbon dioxide (CO2) to the atmosphere and may substantially help to decelerate global warming. There is an ... -
Climate change's effect on transportation of PCBs
(Bachelor thesis, 2022)Studier indikerer at klima endringer og høyere temperaturer stimulerer transporten, oppdelingen og volatiliteten til polyklorerte bifenyler (PCBer). PCBer er vedvarende organiske forurensninger, som er giftige for miljøet. ... -
CO2 hydrogenation to light olefins over metal supported SAPO-34
(Bachelor thesis, 2021)Direkte hydrogenering av karbondioksid til høyverdige kjemikalier er en lovende strategi for å lukke karbonsyklusen ved å redusere overskuddet av karbondioksid i atmosfæren og samtidig minske avhengigheten av fossile ... -
CO2 induced phase transitions in diamine-appended metal-organic frameworks
(Journal article; Peer reviewed, 2015)Using a combination of density functional theory and lattice models, we study the effect of CO2 adsorption in an amine functionalized metal organic framework. These materials exhibit a step in the adsorption isotherm ... -
Collaborative automation and IoT technologies for coastal ocean observing systems
(Journal article; Peer reviewed, 2021) -
Combating Antibiotic Resistance by Chemical Synthesis: Creation of new varieties of Glycopeptide Antiobiotics based on Vancomycin
(Bachelor thesis, 2021)The emergence of multi-resistant bacteria has been described by WHO as the gravest disease threat we face, claiming up to 700,000 lives annually. Antibiotics of last-resort, such as the glycopeptide class antibiotic ... -
Combined Effects of Silver Nanoparticles and 17α-ethinyl estradiol on Turbot (Scophthalmus maximus)
(Master thesis, 2015)Due to their antimicrobial properties silver nanoparticles are one of the most used nanomaterials in the commercially available products nowadays. The exponential increase in production of nanomaterials raises concerns ... -
A comparative study of experiments and theories on steady-state evaporation of water
(Journal article, 2022)A precise description of energy and mass transport across the liquid-vapor interface of water is central in dis- ciplines spanning from climatology to seawater desalination. We present a critical assessment of six recent ... -
Comparing PFAS concentrations in non-functional recycled and post-consumer textiles: Implications for a toxic-free circular economy
(Master thesis, 2023)Tilstedeværelse av per- og polyfluoralkylstoffer (PFAS) i tekstiler regnes som en hinder for å oppnå materialsykluser fri for miljøgifter under ønsket om å øke resirkuleringsraten for tektiler under EU’s handlingsplan for ... -
Comparing Structural Features of Flavonoid Derivatives for Enhancing Inhibition of Multidrug Resistant Cancer Mediating ABC transporters: P-gp and BCRP
(Bachelor thesis, 2021)ABC transporters are a family of transmembrane proteins that serve multiple physiological functions by pumping unwanted substances out of different cells (efflux).(1) However, some ABC transporters, including Breast Cancer ...