Blar i Institutt for konstruksjonsteknikk på forfatter "Lechleitner, Margarete"

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    • Deficiency of B vitamins leads to cholesterol-independent atherogenic transformation of the aorta 

      Almer, Gunter; Opriessnig, Peter; Wolinski, Heimo; Sommer, Gerhard; Diwoky, Clemens; Lechleitner, Margarete; Kolb, Dagmar; Bubalo, Vladimir; Brunner, Markus S.; Schwarz, Andreas N.; Leitinger, Gerd; Schoiswohl, Gabriele; Marsche, Gunther; Niedrist, Tobias; Schauer, Silvia; Oswald, Wolfgang; Groselj-Strele, Andrea; Paar, Margret; Cvirn, Gerhard; Hoefler, Gerald; Rechberger, Gerald N.; Herrmann, Markus; Frank, Saša; Holzapfel, Gerhard; Kratky, Dagmar; Mangge, Harald; Hörl, Gerd; Tehlivets, Oksana (Peer reviewed; Journal article, 2022)
      Atherosclerosis, the leading cause of cardiovascular disease responsible for the majority of deaths worldwide, cannot be sufficiently explained by established risk factors, including hypercholesterolemia. Elevated plasma ...

    • Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice 

      Amor, Melina; Bianco, Valentina; Buerger, Martin; Lechleitner, Margarete; Vujić, Nemanja; Dobrijević, Anja; Akhmetshina, Alena; Pirchheim, Anita; Schwarz, Birgit; Pessentheiner, Ariane R.; Baumgartner, Franziska; Rampitsch, Katharina; Schauer, Silvia; Klobučar, Iva; Degoricija, Vesna; Pregartner, Gudrun; Kummer, Daniel; Svecla, Monika; Sommer, Gerhard; Kolb, Dagmar; Holzapfel, Gerhard; Hoefler, Gerald; Frank, Saša; Norata, Giuseppe Danilo; Kratky, Dagmar (Journal article; Peer reviewed, 2023)
      Background Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic ...