Browsing NTNU Open by Author "White, Linda Rosemary"

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    • Alzheimer´s disease: Possible biomarkers for prediction and progression 

      Grøntvedt, Gøril Rolfseng (Doctoral theses at NTNU;2022:355, Doctoral thesis, 2022)
      Alzheimers sykdom (AD) er den vanligste årsaken til svikt i kognitive funksjoner og demens og utgjør minst 60 % av alle demenstilfellene. AD er en nevrodegenerativ sykdom som fører til tap av nerveceller. Vi vet at sykdommen ...

    • The Amyloid, Tau, and Neurodegeneration (A/T/N) Classification Applied to a Clinical Research Cohort with Long-Term Follow-Up 

      Grøntvedt, Gøril Rolfseng; Lauridsen, Camilla; Berge, Guro; White, Linda Rosemary; Salvesen, Øyvind; Bråthen, Geir; Sando, Sigrid Botne (Peer reviewed; Journal article, 2020)
      Background: The unbiased amyloid, tau, and neurodegeneration (A/T/N) classification is designed to characterize individuals in the Alzheimer continuum and is currently little explored in clinical cohorts. Objective: A ...

    • Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease 

      Patra, Kalicharan; Soosaipillai, Antoninus; Sando, Sigrid Botne; Lauridsen, Camilla; Berge, Guro; Møller, Ina; Grøntvedt, Gøril Rolfseng; Bråthen, Geir; Begcevic, Ilijana; Moussaud, Simon; Minthon, Lennart; Hansson, Oskar; Diamandis, Eleftherios P.; White, Linda Rosemary; Nielsen, Henrietta M. (Journal article; Peer reviewed, 2018)
      Background Kallikrein 6 (KLK6) is known to be an age-related protease expressed at high levels in the central nervous system. It was previously shown to be involved in proteolysis of extracellular proteins implicated in ...

    • Association between cytokines and psychiatric symptoms in chronic fatigue syndrome and healthy controls 

      Groven, Nina; Fors, Egil Andreas; Iversen, Valentina Cabral; White, Linda Rosemary; Reitan, Solveig Merete Klæbo (Journal article; Peer reviewed, 2018)
      Purpose: The reports regarding the status of the immune system in patients with chronic fatigue syndrome/myalgic encephalopathy (CFS/ME) have been inconclusive. We approached this question by comparing a strictly defined ...

    • Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden 

      Grøntvedt, Gøril Rolfseng; Sando, Sigrid Botne; Lauridsen, Camilla; Bråthen, Geir; White, Linda Rosemary; Salvesen, Øyvind; Aarsland, Dag; Hessen, Erik; Fladby, Tormod; Waterloo, Knut K; Scheffler, Katja (Journal article; Peer reviewed, 2022)

    • Cut-off evaluation of intrathecal oligoclonal bands of IgM in relapsing-remitting multiple sclerosis; a retrospective study 

      Hvaring, Charlotte Maria; Alawad, Noor; Salvesen, Øyvind; Hovdal, Harald Olav; White, Linda Rosemary; Boullerne, Anne (Peer reviewed; Journal article, 2022)
      Background Multiple sclerosis (MS) is the most common demyelinating disease and characterized by immunological changes. Oligoclonal bands of IgG in CSF not seen in corresponding serum have been used for many years as ...

    • Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk 

      Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K.; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina Selseth; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan A.; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G.; Snædal, Jón G.; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda Rosemary; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick; van der Flier, Wiesje M.; Dobson, Richard; Davis, Lea K; Stefánsson, Hreinn; Stefánsson, Kári; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole Andreas; Posthuma, Danielle (Journal article; Peer reviewed, 2019)
      Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci ...

    • Incidence of Young Onset Dementia in Central Norway: A Population-Based Study 

      Kvello-Alme, Marte; Bråthen, Geir; White, Linda Rosemary; Sando, Sigrid Botne (Peer reviewed; Journal article, 2020)
      Background: The epidemiology of young onset dementia is little researched compared to late onset dementia. Information on incidence rates is vital for medical professionals, and for government planning purposes. Objective: ...

    • Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci 

      Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2018)
      A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ...

    • Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease 

      Giannisis, Andreas; Al-Grety, Asma; Carlsson, Henrik; Patra, Kalicharan; Twohig, Daniel; Sando, Sigrid Botne; Lauridsen, Camilla; Berge, Guro; Grøntvedt, Gøril Rolfseng; Bråthen, Geir; White, Linda Rosemary; Kultima, Kim; Nielsen, Henrietta M. (Peer reviewed; Journal article, 2022)
      Background Low levels of plasma apolipoprotein E (apoE) and presence of the APOE ε4 allele are associated with an increased risk of Alzheimer’s disease (AD). Although the increased risk of AD in APOE ε4-carriers is ...

    • The prevalence and subtypes of young onset dementia in central Norway: A population-based study 

      Kvello-Alme, Marte; Bråthen, Geir; White, Linda Rosemary; Sando, Sigrid Botne (Peer reviewed; Journal article, 2019)
      Background: Young onset dementia poses several challenges for the individual, health care, and society that are not normally relevant for late onset dementia, but is little researched. Objective: To determine the ...

    • Safety and efficacy of plasma transfusion from exercise - trained donors in patients with early Alzheimer’s disease: protocol for the ExPlas study 

      Tari, Atefe R; Berg, Helene Haugen; Videm, Vibeke; Bråthen, Geir; White, Linda Rosemary; Røsbjørgen, Ragnhild; Scheffler, Katja; Dalen, Håvard; Holte, Espen; Håberg, Asta Kristine; Selbæk, Geir; Lydersen, Stian; Duezel, Emrah; Bergh, Sverre; Logan-halvorsrud, Kjell Rune; Sando, Sigrid Botne; Wisløff, Ulrik (Peer reviewed; Journal article, 2022)
      Introduction Given that exercise training reduces the risk of developing Alzheimer’s disease (AD), induces changes in the blood composition and has widespread systemic benefits, it is reasonable to hypothesise that exercised ...

    • The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease 

      Twohig, Daniel; Rodriguez-Vieitez, Elena; Sando, Sigrid Botne; Berge, Guro; Lauridsen, Camilla; Møller, Ina; Grøntvedt, Gøril Rolfseng; Bråthen, Geir; Patra, Kalicharan; Bu, Guojun; Benzinger, Tammie; Karch, Celeste M.; Fagan, Anne M.; Morris, John C.; Bateman, Randall J.; Nordberg, Agneta; White, Linda Rosemary; Nielsen, Henrietta M. (Journal article; Peer reviewed, 2018)
      Accumulating evidence demonstrating higher cerebrospinal fluid (CSF) α-synuclein (αSyn) levels and αSyn pathology in the brains of Alzheimer’s disease (AD) patients suggests that αSyn is involved in the pathophysiology of ...

    • Time to diagnosis in young onset alzheimer's disease: A population-based study from central Norway 

      Kvello-Alme, Marte; Bråthen, Geir; White, Linda Rosemary; Sando, Sigrid Botne (Peer reviewed; Journal article, 2021)
      Background: Young onset dementia is associated with a longer time to diagnosis compared to late onset dementia. Earlier publications have indicated that atypical presentation is a key contributing factor to the diagnostic ...