Browsing NTNU Open by Author "Vandsemb, Esten Nymoen"
Now showing items 1-8 of 8
-
Highly expressed genes in multiple myeloma cells – what can they tell us about the disease?
Børset, Magne; Elsaadi, Samah; Vandsemb, Esten Nymoen; Hess, Eli Svorkdal; Steiro, Ida Johnsen; Cócera Fernández, Miguel; Sponaas, Anne-Marit; Abdollahi, Pegah (Peer reviewed; Journal article, 2022)Cancer cells can convert proto-oncoproteins into oncoproteins by increasing the expression of genes that are oncogenic when expressed at high levels. Such genes can promote oncogenesis without being mutated. To find ... -
Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells
Mahammad, Nur; Ashcroft, Felicity; Feuerherm, Astrid Jullumstrø; Elsaadi, Samah; Vandsemb, Esten Nymoen; Børset, Magne; Johansen, Berit (Peer reviewed; Journal article, 2021)Cytosolic phospholipase A2α (cPLA2α) is the rate-limiting enzyme in releasing arachidonic acid and biosynthesis of its derivative eicosanoids. Thus, the catalytic activity of cPLA2α plays an important role in cellular ... -
Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration
Vandsemb, Esten Nymoen; Bertilsson, Helena; Abdollahi, Pegah; Størkersen, Øystein; Våtsveen, Thea Kristin; Rye, Morten Beck; Rø, Torstein Baade; Børset, Magne; Slørdahl, Tobias Schmidt (Journal article; Peer reviewed, 2016)Background: PRL-3 is a phosphatase implicated in oncogenesis in multiple cancers. In some cancers, notably carcinomas, PRL-3 is also associated with inferior prognosis and increased metastatic potential. In this study we ... -
Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance
Hjort, Magnus Aassved; Abdollahi, Pegah; Vandsemb, Esten Nymoen; Fenstad, Mona H.; Lund, Bendik; Slørdahl, Tobias Schmidt; Børset, Magne; Rø, Torstein Baade (Journal article; Peer reviewed, 2017)Phosphatase of regenerating liver-3 (PRL-3/PTP4A3) is upregulated in multiple cancers, including BCR-ABL1- and ETV6-RUNX-positive acute lymphoblastic leukemia (ALL). With this study, we aim to characterize the biological ... -
Phosphatases of regenerating liver are key regulators of metabolism in cancer cells - role of Serine/Glycine metabolism
Abdollahi, Pegah; Vandsemb, Esten Nymoen; Børset, Magne (Peer reviewed; Journal article, 2022)Purpose of review Phosphatases of regenerating liver (PRL) are dual-specificity phosphatases and comprise three members, PRL-1, -2 and -3. Despite the importance of PRLs as oncoproteins, there is no consensus function ... -
Src family kinases are regulated in multiple myeloma cells by phosphatase of regenerating liver-3
Abdollahi, Pegah; Vandsemb, Esten Nymoen; Hjort, Magnus Aassved; Misund, Kristine; Holien, Toril; Sponaas, Anne-Marit; Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Børset, Magne (Journal article; Peer reviewed, 2016)Phosphatase of regenerating liver-3 (PTP4A3/PRL-3) is a dual-specificity phosphatase that is upregulated in various types of cancers and is related to poor prognosis and aggressive tumor behavior. The expression level of ... -
TAK1-inhibitors did not reduce disease burden in a Vκ*MYC model of multiple myeloma
Håland, Erling; Moen, Ingrid Nyhus; Vandsemb, Esten Nymoen; Starheim, Kristian K. (Peer reviewed; Journal article, 2022)Objective Multiple myeloma is a haematological malignancy characterized by proliferation of monoclonal plasma cells in the bone marrow. Development of resistance and minimal residual disease remain challenging in the ... -
The influence of PRL3 on the IL-6 pathway in multiple myeloma: an explorative analysis using transcriptomics and proteomics
Vandsemb, Esten Nymoen (Master thesis, 2017)BACKGROUND: Multiple myeloma (MM) is an incurable malignancy of plasma cells. So far, blocking single growth factors, such as IL-6, has not led to improved patient survival in MM. We have previously published promising in ...