Blar i NTNU Open på forfatter "Sulheim, Snorre"
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Addressing uncertainty in genome-scale metabolic model reconstruction and analysis
Bernstein, David; Sulheim, Snorre; Almaas, Eivind; Segrè, Daniel (Peer reviewed; Journal article, 2021)The reconstruction and analysis of genome-scale metabolic models constitutes a powerful systems biology approach, with applications ranging from basic understanding of genotype-phenotype mapping to solving biomedical and ... -
Assembly and application of genome-scale metabolic models to study Streptomyces coelicolor and Prochlorococcus
Sulheim, Snorre (Doctoral theses at NTNU;2021:96, Doctoral thesis, 2021)Summary: Metabolism is the set of all chemical reactions responsible for the conversion of nutrients into the energy and cellular building blocks required for growth and cellular maintenance in a living organism. Because ... -
Automatic Reconstruction of Metabolic Pathways for Ribosomally Synthesized and Post-translationally Modified Peptides
Thorsplass, Adrian (Master thesis, 2023)Biosyntetiske genkluster (BGC-er) fasiliterer produksjonen av sekundære metabolitter i organismer. Disse forbindelsene er kjent for å ha nyttige egenskaper som antibiotisk, antiviral eller anti-tumor aktivitet. Imidlertid ... -
Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters
Sulheim, Snorre; Fossheim, Fredrik A.; Wentzel, Alexander; Almaas, Eivind (Peer reviewed; Journal article, 2021)Background A wide range of bioactive compounds is produced by enzymes and enzymatic complexes encoded in biosynthetic gene clusters (BGCs). These BGCs can be identified and functionally annotated based on their DNA ... -
Constructing Metabolic Pathways from Identified Biosynthetic Gene Clusters
Fossheim, Fredrik Aunaas (Master thesis, 2020)Vi har i dette arbeidet utviklet og implementert en algoritme som konverterer informasjon om predikerte biosyntetiske genklustere (BGC'er) som gitt av antiSMASH til metabolske reaksjonsveier for bruk i genomskalamodeller ... -
Dynamic Allocation of Carbon Storage and Nutrient-Dependent Exudation in a Revised Genome-Scale Model of Prochlorococcus
Ofaim, Shany; Sulheim, Snorre; Almaas, Eivind; Sher, Daniel; Segrè, Daniel (Peer reviewed; Journal article, 2021)Microbial life in the oceans impacts the entire marine ecosystem, global biogeochemistry and climate. The marine cyanobacterium Prochlorococcus, an abundant component of this ecosystem, releases a significant fraction of ... -
Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production
Sulheim, Snorre; Kumelj, Tjasa; van Dissel, Dino; Salehzadeh-Yazdi, Ali; Chao, Du; Van Wezel, Gilles P.; Nieselt, Kay; Almaas, Eivind; Wentzel, Alexander; Kerkhoven, Eduard J (Journal article; Peer reviewed, 2020)Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the engineered Streptomyces coelicolor M1152 is a widely used host ... -
Genome-Scale Modeling of Embryonic Stem Cells
Nyhamar, Kristen (Master thesis, 2023)Genom-skala metabolisk modellering har nylig blitt et sentralt verktøy innen bioteknologi. I denne masteroppgaven er målet å bruke rammeverket sMOMENT til å kombinere omics-data med en genom-skala metabolisk rekonstruksjon ... -
Method development and automated analysis of ultrasound images of phase-shift bubbles.
Sulheim, Snorre (Master thesis, 2015)Ultrasound mediated drug delivery is an important tool in the fight against cancer. A new concept called Acoustic Cluster Therapy (ACT ) is under development, and two pilot imaging studies have been performed on prostate cancer ... -
Predicting strain engineering strategies using iKS1317: a genome-scale metabolic model of Streptomyces coelicolor
Kumelj, Tjasa; Sulheim, Snorre; Wentzel, Alexander; Almaas, Eivind (Journal article; Peer reviewed, 2018)Streptomyces coelicolor is a model organism for the Actinobacteria, a phylum known to produce an extensive range of different bioactive compounds that include antibiotics currently used in the clinic. Biosynthetic gene ...