Browsing NTNU Open by Author "Stunes, Astrid Kamilla"
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Adipokines, peroxisome Proliferator Activated Receptor (PPAR) Agonists and Serotonin-Common Regulators of Bone and Fat Metabolism
Stunes, Astrid Kamilla (Doktoravhandlinger ved NTNU, 1503-8181; 2008:313, Doctoral thesis, 2008)Osteporosis and obestity are diseases with rapidly increasing prevalence, and have both become major health problems. These diseases share several common genetic and enviromental factors, and thus a relation between bone ... -
Adiponectin prevents orthodontic tooth movement in rats
Haugen, Sigrid; Aasarød, Kristin Matre; Stunes, Astrid Kamilla; Mosti, Mats Peder; Franzen, Tanya Jeanette; Vandevska-Radunovic, Vaska; Syversen, Unni; Reseland, Janne Elin (Journal article; Peer reviewed, 2017)Objective The objective was to examine the effects of repetitive local administration of adiponectin on experimental tooth movement in rats. Materials and methods The maxillary right first molar of male Wistar rats ... -
Adiponectin reduces bone stiffness; verified in a 3D artificial human bone model in vitro
Haugen, Sigrid; He, Jianying; Sundaresan, Alamelu; Stunes, Astrid Kamilla; Aasarød, Kristin Matre; Tiainen, Hanna; Syversen, Unni; Skallerud, Bjørn Helge; Reseland, Janne Elin (Journal article; Peer reviewed, 2018)Primary human osteoblasts and osteoclasts incubated in a rotating coculture system without any scaffolding material, form bone-like tissue that may be used to evaluate effects of various compounds on mechanical strength. ... -
Alterations in the Vitamin D endocrine system during pregnancy: A longitudinal study of 855 healthy Norwegian women
Gustafsson, Miriam; Romundstad, Pål Richard; Stafne, Signe Nilssen; Helvik, Anne-Sofie; Stunes, Astrid Kamilla; Mørkved, Siv; Salvesen, Kjell Å; Thorsby, Per Medbøe; Syversen, Unni (Journal article; Peer reviewed, 2018)To ensure optimal calcium accrual in the fetal skeleton, a substantial rise occurs in 1,25-dihydroxyvitamin D (1,25(OH)2D), but is dependent on sufficient 25-hydroxyvitamin (25(OH)D). Large longitudinal studies addressing ... -
Cytokines in agitated and non-agitated patients admitted to an acute psychiatric department: A cross-sectional study
Larsen, Jeanette Brun; Stunes, Astrid Kamilla; Vaaler, Arne; Reitan, Solveig Merete Klæbo (Journal article; Peer reviewed, 2019)Background:Different psychiatric diagnostic groups have been reported to have cytokine levels deviating from healthy controls. In acute clinical settings however, the specific challenging symptoms and signs are more important ... -
Developmental Origins of Disease: Influence of low birth weight and maternal vitamin A and D status on offspring skeletal health and metabolic outcomes at adulthood
Balasuriya, Chandima N.D. (Doctoral theses at NTNU;2018:221, Doctoral thesis, 2018)Developmental origins of adult health and disease (DOHaD) has gained increased attention during the past few decades. Birth size reflects the prenatal environment, and there is substantial evidence that low birth weight ... -
Effects of vitamin D supplementation on bone turnover markers and other bone-related substances in subjects with vitamin D deficiency
Jorde, Rolf; Stunes, Astrid Kamilla; Kubiak, Julia Magdalena; Joakimsen, Ragnar Martin; Grimnes, Guri; Thorsby, Per Medbøe; Syversen, Unni (Journal article; Peer reviewed, 2019)In observational studies, vitamin D deficiency is a risk factor for low bone density and future fractures, whereas a causal relation has been difficult to show in randomized controlled trials (RCTs). Similarly, vitamin D ... -
Frequency of risk factors and long-term complications in a female population with previously diagnosed diabetes mellitus in rural Nepal
Tingulstad, Katharina Antonia Kocheise (Master thesis, 2017)Background: Diabetes mellitus (DM) is a noncommunicable disease causing 1.5 million deaths annually in 2012. Its global prevalence is growing dramatically, projecting to 10.4% of the adult population in 2040. Almost 75% ... -
Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice
Aasarød, Kristin Matre; Waldum, Helge; Stunes, Astrid Kamilla; Sandvik, Arne Kristian; Flatberg, Arnar; Mjønes, Patricia; Syversen, Unni; Bakke, Ingunn; Fossmark, Reidar (Journal article; Peer reviewed, 2020)Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric ... -
Impaired skeletal health and neuromuscular function among amphetamine users in clinical treatment
Mosti, Mats Peder; Flemmen, Grete; Hoff, Jan; Stunes, Astrid Kamilla; Syversen, Unni; Wang, Eivind (Journal article; Peer reviewed, 2016)Summary This study examined musculoskeletal health in amphetamine users, compared with healthy age-matched controls. We show that amphetamine users have reduced bone mass at several skeletal sites and attenuated maximal ... -
In vitro effects of radiation and mechanical load on murine osteocytes MLO-Y4
Jongen, Vincent Alexander (Master thesis, 2020)The increased survival rates for cancer as a result of improved diagnosis and treatment has come with the drawback that cancer treatment side effects are becoming more frequent as well. Cancer treatment induced bone loss ... -
In vitro effects of the AMP-activated protein kinase agonist metformin on murine osteocytes MLO-Y4
Homstad, Mathilde (Master thesis, 2020)Osteoporose er en skjelettsykdom som gir økt risiko for beinbrudd. Sykdommen karakteriseres av nedsatt beinkvalitet og lav beinmasse, og er en økende bekymring grunnet en økt aldrende befolkning. Styrketrening er vist å ... -
Lipocalin 2 is expressed in MLO-Y4 osteocytes and regulated by the peroxisome proliferator activated receptor α agonist fenofibrate.
Syversen, Unni (Master thesis, 2020)Background: Lipocalin 2 is highly expressed and secreted from osteoblasts in mice. Lately, bone-derived lipocalin 2 has been shown to suppress appetite by binding to the MC4R in hypothalamus. In the present study we wanted ... -
Maternal serum retinol, 25(OH)D and 1,25(OH)2D concentrations during pregnancy and peak bone mass and trabecular bone score in adult offspring at 26-year follow-up
Balasuriya, Chandima Nirupa Dilruks; Larose, Tricia L; Mosti, Mats Peder; Evensen, Kari Anne Indredavik; Jacobsen, Geir Wenberg; Thorsby, Per Medbøe; Stunes, Astrid Kamilla; Syversen, Unni (Journal article; Peer reviewed, 2019)Background Vitamin A and D deficiency is prevalent in pregnant women worldwide. Both vitamins are involved in fetal skeletal development. A positive association between maternal vitamin D levels and offspring bone mineral ... -
Peak bone mass and bone microarchitecture in adults born with low birth weight preterm or at term: A cohort study
Balasuriya, Chandima Nirupa Dilruks; Evensen, Kari Anne Indredavik; Mosti, Mats Peder; Brubakk, Ann-Mari; Jacobsen, Geir Wenberg; Indredavik, Marit Sæbø; Schei, Berit; Stunes, Astrid Kamilla; Syversen, Unni (Journal article; Peer reviewed, 2017)Context and Objectives: Peak bone mass (PBM) is regarded as the most important determinant of osteoporosis. Growing evidence suggests a role of intrauterine programming in skeletal development. We examined PBM and trabecular ... -
Skeletal effects of plyometric exercise and metformin in ovariectomized rats
Stunes, Astrid Kamilla; Erben, Reinhold G.; Schüler, Christiane; Eriksen, Erik Fink; Tice, Matthew; Vashishth, Deepak; Syversen, Unni; Mosti, Mats Peder (Journal article; Peer reviewed, 2019)Estrogen deficiency causes bone loss and skeletal muscle dysfunction, and attenuates the musculoskeletal effects of exercise. The anti-diabetic drug metformin has been suggested to promote beneficial skeletal effects. To ... -
Skeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in rats
Stunes, Astrid Kamilla; Westbroek, Irene; Fossmark, Reidar; Berge, Rolf Kristian; Reseland, Janne Elin; Syversen, Unni (Journal article; Peer reviewed, 2011)This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), ... -
Smoking and other determinants of bone turnover
Jorde, Rolf; Stunes, Astrid Kamilla; Kubiak, Julia Magdalena; Grimnes, Guri; Thorsby, Per Medbøe; Syversen, Unni (Journal article; Peer reviewed, 2019)The balance between bone resorption and formation may be assessed by measurement of bone turnover markers (BTMs), like carboxyl-terminal cross-linked telopeptide of type 1 collagen (CTX-1) and procollagen type 1 amino-terminal ... -
The effect of an exercise program in pregnancy on vitamin D status among healthy, pregnant Norwegian women: a randomized controlled trial
Gustafsson, Miriam K.; Romundstad, Pål Richard; Stafne, Signe Nilssen; Helvik, Anne-Sofie; Stunes, Astrid Kamilla; Mørkved, Siv; Salvesen, Kjell Å; Thorsby, Per Medbøe; Mosti, Mats Peder; Syversen, Unni (Journal article; Peer reviewed, 2019)Background Vitamin D insufficiency is common in pregnant women worldwide. Regular prenatal exercise is considered beneficial for maternal and fetal health. There is a knowledge gap regarding the impact of prenatal ... -
The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats
Stunes, Astrid Kamilla; Westbroek, Irene; Gustafsson, Björn; Fossmark, Reidar; Waarsing, Jan H; Eriksen, Erik Fink; Petzold, Christiane; Reseland, Janne Elin; Syversen, Unni (Journal article; Peer reviewed, 2011)Background Activation of peroxisome proliferator-activated receptor (PPAR)gamma is associated with bone loss and increased fracture risk, while PPARalpha activation seems to have positive skeletal effects. To further ...