Blar i NTNU Open på forfatter "Stunes, Astrid Kamilla"
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In vitro effects of the AMP-activated protein kinase agonist metformin on murine osteocytes MLO-Y4
Homstad, Mathilde (Master thesis, 2020)Osteoporose er en skjelettsykdom som gir økt risiko for beinbrudd. Sykdommen karakteriseres av nedsatt beinkvalitet og lav beinmasse, og er en økende bekymring grunnet en økt aldrende befolkning. Styrketrening er vist å ... -
Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal ligament
Yang, Yang; Pullisaar, Helen; Stunes, Astrid Kamilla; Parreiras Nogueira, Liebert; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2023)Objectives Positive effects of irisin on osteogenic differentiation of periodontal ligament (PDL) cells have been identified previously, this study aims to examine its effect on orthodontic tooth movement (OTM) in ... -
Lipocalin 2 is expressed in MLO-Y4 osteocytes and regulated by the peroxisome proliferator activated receptor α agonist fenofibrate.
Syversen, Unni (Master thesis, 2020)Background: Lipocalin 2 is highly expressed and secreted from osteoblasts in mice. Lately, bone-derived lipocalin 2 has been shown to suppress appetite by binding to the MC4R in hypothalamus. In the present study we wanted ... -
Maternal serum retinol, 25(OH)D and 1,25(OH)2D concentrations during pregnancy and peak bone mass and trabecular bone score in adult offspring at 26-year follow-up
Balasuriya, Chandima Nirupa Dilruks; Larose, Tricia L; Mosti, Mats Peder; Evensen, Kari Anne Indredavik; Jacobsen, Geir Wenberg; Thorsby, Per Medbøe; Stunes, Astrid Kamilla; Syversen, Unni (Journal article; Peer reviewed, 2019)Background Vitamin A and D deficiency is prevalent in pregnant women worldwide. Both vitamins are involved in fetal skeletal development. A positive association between maternal vitamin D levels and offspring bone mineral ... -
Maternal vitamin D status in pregnancy and molar incisor hypomineralisation and hypomineralised second primary molars in the offspring at 7–9 years of age: a longitudinal study
Børsting, Torunn; Schuller, Annemarie; van Dommelen, Paula; Stafne, Signe Nilssen; Skeie, Marit Slåttelid; Skaare, Anne; Mørkved, Siv; Salvesen, Kjell Å; Stunes, Astrid Kamilla; Mosti, Mats Peder; Gustafsson, Miriam Katarina; Syversen, Unni; Fagerhaug, Tone Natland (Peer reviewed; Journal article, 2022)Purpose The study aimed to investigate associations between maternal vitamin D status during pregnancy and molar incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM) among children. Methods The ... -
Maximal strength training-induced increase in efferent neural drive is not reflected in relative protein expression of SERCA
Tøien, Tiril; Haglo, Håvard Pedersen; Nyberg, Stian Kwak; Rao, Shalini Vasudev; Stunes, Astrid Kamilla; Mosti, Mats Peder; Wang, Eivind (Peer reviewed; Journal article, 2021)Introduction Maximal strength training (MST), performed with heavy loads (~ 90% of one repetition maximum; 1RM) and few repetitions, yields large improvements in efferent neural drive, skeletal muscle force production, and ... -
Peak bone mass and bone microarchitecture in adults born with low birth weight preterm or at term: A cohort study
Balasuriya, Chandima Nirupa Dilruks; Evensen, Kari Anne Indredavik; Mosti, Mats Peder; Brubakk, Ann-Mari; Jacobsen, Geir Wenberg; Indredavik, Marit Sæbø; Schei, Berit; Stunes, Astrid Kamilla; Syversen, Unni (Journal article; Peer reviewed, 2017)Context and Objectives: Peak bone mass (PBM) is regarded as the most important determinant of osteoporosis. Growing evidence suggests a role of intrauterine programming in skeletal development. We examined PBM and trabecular ... -
Plasma levels of fibroblast growth factor 23 in pregnant Norwegian women and relation with adverse pregnancy outcomes
Nesland, Lars Andreas Haga (Master thesis, 2022)Bakgrunn: Fibroblast vekstfaktor 23 (FGF23) syntetiseres hovedsakelig i osteocytter. Det regulerer nivåene av fosfat og vitamin D. Placenta uttrykker både reseptoren og ko-reseptoren til FGF23, samt gener som er kjente mål ... -
Prevalence of fractures among women in rural Nepal and association with diabetes
Granqvist, Emil; Krøvel, Jonas (Master thesis, 2021)Bakgrunn Osteoporose og diabetes er sjukdommar med alarmerande høg prevalens over heile verda og er sjukdommar det fins både gode førebyggande tiltak og behandlingar mot. Det eksisterer lite data om prevalensen av osteoporose ... -
Prevalence of fractures among women in rural Nepal and association with diabetes
Granqvist, Emil; Krøvel, Jonas (Master thesis, 2021)Bakgrunn Osteoporose og diabetes er sjukdommar med alarmerande høg prevalens over heile verda og er sjukdommar det fins både gode førebyggande tiltak og behandlingar mot. Det eksisterer lite data om prevalensen av osteoporose ... -
Prevalence of metabolic syndrome and associated risk factors among married women in a rural community of Nepal: A population-based study
Shrestha, Ayush (Master thesis, 2021)ABSTRACT Introduction: Metabolic syndrome (MetS) is a constellation of conditions including hypertension, hyperglycemia, central obesity and dyslipidemia, known to increase the risk for diabetes type 2 (T2D) and cardiovascular ... -
Radiation therapy and training effects on the mechanical performance of bone
Auestad, Martin Fridheim (Master thesis, 2021)Med stadig stigende forventet levealder oppstår nye aldersrelaterte utfordringer. Eksponering for både osteoporotiske brudd og kreft øker med alder, og flere tilfeller oppdages siden ny teknologi for medisinsk undersøkelse ... -
Skeletal effects of plyometric exercise and metformin in ovariectomized rats
Stunes, Astrid Kamilla; Erben, Reinhold G.; Schüler, Christiane; Eriksen, Erik Fink; Tice, Matthew; Vashishth, Deepak; Syversen, Unni; Mosti, Mats Peder (Journal article; Peer reviewed, 2019)Estrogen deficiency causes bone loss and skeletal muscle dysfunction, and attenuates the musculoskeletal effects of exercise. The anti-diabetic drug metformin has been suggested to promote beneficial skeletal effects. To ... -
Skeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in rats
Stunes, Astrid Kamilla; Westbroek, Irene; Fossmark, Reidar; Berge, Rolf Kristian; Reseland, Janne Elin; Syversen, Unni (Journal article; Peer reviewed, 2011)This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), ... -
Smoking and other determinants of bone turnover
Jorde, Rolf; Stunes, Astrid Kamilla; Kubiak, Julia Magdalena; Grimnes, Guri; Thorsby, Per Medbøe; Syversen, Unni (Journal article; Peer reviewed, 2019)The balance between bone resorption and formation may be assessed by measurement of bone turnover markers (BTMs), like carboxyl-terminal cross-linked telopeptide of type 1 collagen (CTX-1) and procollagen type 1 amino-terminal ... -
Status of vitamin A among overweight/obese pregnant women: relation to pregnancy complications, birth weight, and metabolic measures
Kinge, Ingvild Tapio (Master thesis, 2022)Den globale prevalensen av vitamin A-mangel og -insuffisiens er høy, og er en av de store årsakene til morbiditet og mortalitet blant barn og gravide, særlig i lavinntektsland. Nyere studier har funnet en sammenheng mellom ... -
The effect of an exercise program in pregnancy on vitamin D status among healthy, pregnant Norwegian women: a randomized controlled trial
Gustafsson, Miriam K.; Romundstad, Pål Richard; Stafne, Signe Nilssen; Helvik, Anne-Sofie; Stunes, Astrid Kamilla; Mørkved, Siv; Salvesen, Kjell Å; Thorsby, Per Medbøe; Mosti, Mats Peder; Syversen, Unni (Journal article; Peer reviewed, 2019)Background Vitamin D insufficiency is common in pregnant women worldwide. Regular prenatal exercise is considered beneficial for maternal and fetal health. There is a knowledge gap regarding the impact of prenatal ... -
The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats
Stunes, Astrid Kamilla; Westbroek, Irene; Gustafsson, Björn; Fossmark, Reidar; Waarsing, Jan H; Eriksen, Erik Fink; Petzold, Christiane; Reseland, Janne Elin; Syversen, Unni (Journal article; Peer reviewed, 2011)Background Activation of peroxisome proliferator-activated receptor (PPAR)gamma is associated with bone loss and increased fracture risk, while PPARalpha activation seems to have positive skeletal effects. To further ... -
Vitamin D and stress urinary incontinence in pregnancy: a cross-sectional study
Stafne, Signe Nilssen; Mørkved, Siv; Gustafsson, Miriam Katarina; Syversen, Unni; Stunes, Astrid Kamilla; Salvesen, Kjell Å; Johannessen, Hege Hølmo (Peer reviewed; Journal article, 2020)Objective To assess the association between levels of vitamin D and urinary incontinence (UI) in pregnancy. Design A cross‐sectional study. Secondary analysis of a randomised controlled trial. Setting Two university ... -
Vitamin D status among overweight/obese pregnant women: associations with pregnancy complications, birth weight and metabolic parameters
Øvreseth, Anna Hundere (Master thesis, 2022)Sammendrag Bakgrunn: Det er en høy prevalens av vitamin D-mangel globalt, både hos gravide og ikke-gravide. Overvektige har lavere nivå av vitamin D enn slanke. Vitamin D stimulerer kalsiumabsorbsjon i tarmen, og er viktig ...