Browsing NTNU Open by Author "Standal, Therese"
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Automated Quantification of Human Osteoclasts Using Object Detection
Kohtala, Sampsa; Nedal, Tonje Marie Vikene; Carlo, Kriesi; Moen, Siv Helen; Ma, Qianli; Ødegaard, Kristin Sirnes; Standal, Therese; Steinert, Martin (Peer reviewed; Journal article, 2022)A balanced skeletal remodeling process is paramount to staying healthy. The remodeling process can be studied by analyzing osteoclasts differentiated in vitro from mononuclear cells isolated from peripheral blood or from ... -
Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone
Westhrin, Marita; Holien, Toril; Zahoor, Muhammad; Moen, Siv Helen; Buene, Glenn; Størdal, Berit Fladvad; Hella, Hanne; Yuan, Huipin; de Bruijn, Joost D; Martens, Anton; Groen, Richard WJ; Bosch, Fátima; Smith, Ulf; Sponaas, Anne-Marit; Sundan, Anders; Standal, Therese (Peer reviewed; Journal article, 2020)Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation. Bone ... -
Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin
Olsen, Oddrun Elise; Wader, Karin Fahl; Misund, Kristine; Våtsveen, Thea Kristin; Rø, Torstein Baade; Mylin, Anne K.; Turesson, I; Størdal, Berit Fladvad; Moen, Siv Helen; Standal, Therese; Waage, Anders; Sundan, Anders; Holien, Toril (Journal article; Peer reviewed, 2014)Multiple myeloma is a malignancy of plasma cells predominantly located in the bone marrow. A number of bone morphogenetic proteins (BMPs) induce apoptosis in myeloma cells in vitro, and with this study we add BMP-9 to the ... -
Bystander memory T cells and IMiD/checkpoint therapy in multiple myeloma: A dangerous tango?
Sponaas, Anne-Marit; Waage, Anders; Vandsemb, Esten; Misund, Kristine; Børset, Magne; Sundan, Anders; Slørdahl, Tobias Schmidt; Standal, Therese (Peer reviewed; Journal article, 2021)In this review article we discuss the role of the memory T cells in multiple myeloma (MM) and how they may influence immune responses in patients that received immunomodulating drugs and check point therapy -
Caspase-8 regulates the expression of pro- and anti-inflammatory cytokines in human bone marrow-derived mesenchymal stromal cells
Moen, Siv Helen; Westhrin, Marita; Zahoor, Muhammad; Nikolai N., Nørgaard; Hella, Hanne; Størdal, Berit Fladvad; Sundan, Anders; Nilsen, Nadra J.; Sponaas, Anne-Marit; Standal, Therese (Journal article; Peer reviewed, 2016)Introduction: Mesenchymal stem cells, also called mesenchymal stromal cells, MSCs, have great potential in stem cell therapy partly due to their immunosuppressive properties. How these cells respond to chronic inflammatory ... -
Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes
Westhrin, Marita; Moen, Siv Helen; Kristensen, Ida Bruun; Buene, Glenn; Mylin, Anne Kærsgaard; Turesson, Ingemar; Abildgaard, Niels; Waage, Anders; Standal, Therese (Journal article; Peer reviewed, 2018)Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it ... -
Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival
Aass, Kristin Roseth; Nedal, Tonje Marie Vikene; Bouma, Siri Anshushaug; Tryggestad, Synne Stokke; Haukås, Einar; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese; Mjelle, Robin (Journal article; Peer reviewed, 2022) -
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
Yang, Rui; Elsaadi, Samah; Misund, Kristine; Abdollahi, Pegah; Vandsemb, Esten; Moen, Siv Helen; Kusnierczyk, Anna; Slupphaug, Geir; Standal, Therese; Waage, Anders; Slørdahl, Tobias Schmidt; Rø, Torstein Baade; Rustad, Even Holth; Sundan, Anders; Hay, Carl; Cooper, Zachary; Schuller, Alwin G.; Woessner, Richard; Borodowski, Alexandra; Menu, Eline; Børset, Magne; Sponaas, Anne-Marit (Peer reviewed; Journal article, 2020)Background PD1/PDL1-directed therapies have been unsuccessful for multiple myeloma (MM), an incurable cancer of plasma cells in the bone marrow (BM). Therefore, other immune checkpoints such as extracellular adenosine and ... -
Dickkopf-1 is associated with periarticular bone loss in patients with rheumatoid arthritis
Grandaunet, Berit Helen Jensen; Syversen, Silje Watterdal; Hoff, Mari; Van der Hejde, Désirée; Haugeberg, Glenn; Kvien, Tore Kristian; Standal, Therese (Journal article; Peer reviewed, 2013-11)Objective: To examine whether cytokines shown to suppress osteoblasts, Dickkopf-1 (DKK1) and hepatocyte growth factor (HGF), are associated with periarticular bone loss in rheumatoid arthritis (RA). Methods: RA patients ... -
Eggshell-derived amorphous calcium phosphate: Synthesis, characterization and bio-functions as bone graft materials in novel 3D osteoblastic spheroids model
Ma, Qianli; Rubenis, Kristaps; Sigurjonsson, Olafur E.; Hildebrand, Torben; Standal, Therese; Zemjane, Signe; Locs, Janis; Loca, Dagnija; Haugen, Håvard Jostein (Journal article, 2023)A multitude of autogenous/allogeneic and semi-synthetic bone graft materials have been developed to reconstruct the defective bone tissue but with high bio-cost and potential environmental pollution. With high calcium ... -
gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation
Standal, Therese; Johnson, Rachelle; McGregor, Narelle; Poulton, Ingrid; Ho, Patricia W M; Martin, T. John; Sims, Natalie (Journal article; Peer reviewed, 2014)Parathyroid hormone (PTH) treatment stimulates osteoblast differentiation and bone formation, and is the only currently approved anabolic therapy for osteoporosis. In cells of the osteoblast lineage, PTH also stimulates ... -
Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss
Zahoor, Muhammad; Westhrin, Marita; Aass, Kristin Roseth; Moen, Siv Helen; Misund, Kristine; Psonka-Antonczyk, Katarzyna Maria; Giliberto, Mariaserena; Buene, Glenn; Sundan, Anders; Waage, Anders; Sponaas, Anne-Marit; Standal, Therese (Journal article; Peer reviewed, 2017)Multiple myeloma (MM) is a hematologic cancer characterized by expansion of malignant plasma cells in the bone marrow. Most patients develop an osteolytic bone disease, largely caused by increased osteoclastogenesis. The ... -
IL-32 and multiple myeloma bone disease
Aass, Kristin Roseth (Master thesis, 2016)Multiple myeloma is a malignancy of plasma cells characterized by multiple tumors in the bone marrow and progressive osteolytic bone disease. The bone lesions are caused by increased bone resorption by osteoclasts and ... -
IL-32 is induced by activation of toll-like receptors in multiple myeloma cells
Aass, Kristin Roseth; Tryggestad, Synne Stokke; Mjelle, Robin; Kastnes, Martin Haugrud; Nedal, Tonje Marie Vikene; Misund, Kristine; Standal, Therese (Peer reviewed; Journal article, 2023)Multiple myeloma (MM) is a hematological cancer characterized by accumulation of malignant plasma cells in the bone marrow. The patients are immune suppressed and suffer from recurrent and chronic infections. Interleukin-32 ... -
Impact of inflammatory signals in multiple myeloma – the role of interleukin-32 and toll-like receptors
Tryggestad, Synne Stokke (Doctoral theses at NTNU;, Doctoral thesis, 2024)En studie av inflammatoriske signaler i myelomatose: fokus på rollen til interleukin-32 og toll-liknende reseptorer Myelomatose, også kalt beinmargkreft, skyldes ukontrollert vekst av plasmaceller i beinmargen. Plasmaceller ... -
Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells
Aass, Kristin Roseth; Mjelle, Robin; Kastnes, Martin Haugrud; Tryggestad, Synne Stokke; van den Brink, Luca M; Roseth, Ingrid Aass; Westhrin, Marita; Zahoor, Muhammad; Moen, Siv Helen; Nedal, Tonje Marie Vikene; Buene, Glenn; Misund, Kristine; Sponaas, Anne-Marit; Ma, Qianli; Sundan, Anders; Groen, Richard WJ; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese (Journal article; Peer reviewed, 2021)Interleukin-32 (IL-32) is a nonclassical cytokine expressed in cancers, inflammatory diseases, and infections. Its expression is regulated by two different oxygen sensing systems; HIF1α and cysteamine dioxygenase (ADO), ... -
Monitoring multiple myeloma by quantification of recurrent mutations in serum
Rustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese; Børset, Magne; Beisvag, Vidar; Myklebost, Ola; Meza, Leonardo Zepeda; Hong, Yan Dai; Sundan, Anders; Waage, Anders (Journal article; Peer reviewed, 2017)Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple myeloma patients and its relation to disease activity during long-term ... -
Multiple myeloma : the interplay between malignant plasma cells and the bonemarrow microenvironment
Standal, Therese (Dissertations at the Faculty of Medicine, 0805-7680; 2006:26272, Doctoral thesis, 2006)The overall objective of this work was to study how myeloma cells influence the bone marrow microenvironment in which they reside, focusing on the cells that resorb or synthesize bone. More specifically we wanted to ... -
Multiple Myeloma: Cancer Cell Intrinsic- and Tumor Microenvironmental Factors
Nedal, Tonje Marie Vikene (Doctoral theses at NTNU;2024:33, Doctoral thesis, 2024)Myelomatose (MM) er en hematologisk kreftsykdom som skyldes ukontrollert vekst av maligne plasmaceller i beinmargen. Myelomatose utvikler seg via to asymptomatiske forstadier: monoklonal gammopati av usikker betydning ... -
New players in an old game: Role of immunoglobulins in the pathogenesis of multiple myeloma
Kovcic, Vlado (Doctoral theses at NTNU;2020:124, Doctoral thesis, 2020)Multiple myeloma is a haematological malignancy characterized by uncontrolled proliferation of malignant plasma cells. The myeloma cells secrete immunoglobulins, which leads to the presence of high levels of monoclonal ...