Browsing NTNU Open by Author "Pettersen, Klas"
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Arterial Stiffening Provides Sufficient Explanation for Primary Hypertension
Pettersen, Klas; Bugenhagen, Scott M.; Nauman, Javaid; Beard, Daniel A.; Omholt, Stig W (Journal article; Peer reviewed, 2014)Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains ... -
Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep
Bojarskaite, Laura; Bjørnstad, Daniel Marelius; Pettersen, Klas; Cunen, Celine; Hermansen, Gudmund Horn; Åbjørsbråten, Knut Sindre; Chambers, Anna; Sprengel, Rolf; Vervaeke, Koen Gerard Alois; Tang, Wannan; Enger, Rune; Nagelhus, Erlend Arnulf (Peer reviewed; Journal article, 2020)Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex ... -
Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow
Holter, Karl Erik; Kehlet, Benjamin Dam; Devor, Anna; Sejnowski, Terrence J.; Dale, Anders M.; Omholt, Stig William; Ottersen, Ole Petter; Nagelhus, Erlend Arnulf; Mardal, Kent-Andre; Pettersen, Klas (Journal article; Peer reviewed, 2017)The brain lacks lymph vessels and must rely on other mechanisms for clearance of waste products, including amyloid β that may form pathological aggregates if not effectively cleared. It has been proposed that flow of ...