• Arterial Stiffening Provides Sufficient Explanation for Primary Hypertension 

      Pettersen, Klas; Bugenhagen, Scott M.; Nauman, Javaid; Beard, Daniel A.; Omholt, Stig W (Journal article; Peer reviewed, 2014)
      Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains ...
    • Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep 

      Bojarskaite, Laura; Bjørnstad, Daniel Marelius; Pettersen, Klas; Cunen, Celine; Hermansen, Gudmund Horn; Åbjørsbråten, Knut Sindre; Chambers, Anna; Sprengel, Rolf; Vervaeke, Koen Gerard Alois; Tang, Wannan; Enger, Rune; Nagelhus, Erlend Arnulf (Peer reviewed; Journal article, 2020)
      Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex ...
    • Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow 

      Holter, Karl Erik; Kehlet, Benjamin Dam; Devor, Anna; Sejnowski, Terrence J.; Dale, Anders M.; Omholt, Stig William; Ottersen, Ole Petter; Nagelhus, Erlend Arnulf; Mardal, Kent-Andre; Pettersen, Klas (Journal article; Peer reviewed, 2017)
      The brain lacks lymph vessels and must rely on other mechanisms for clearance of waste products, including amyloid β that may form pathological aggregates if not effectively cleared. It has been proposed that flow of ...