• A randomised controlled study of the long-term effects of exercise training on mortality in elderly people: Study protocol for the generation 100 study 

      Stensvold, Dorthe; Viken, Hallgeir; Rognmo, Øivind; Skogvoll, Eirik; Steinshamn, Sigurd Loe; Vatten, Lars Johan; Coombes, Jeff S; Anderssen, Sigmund Alfred; Magnussen, Jon; Ingebrigtsen, Jan Erik; Singh, Maria A Fiatarone; Langhammer, Arnulf; Støylen, Asbjørn; Helbostad, Jorunn L.; Wisløff, Ulrik (Journal article; Peer reviewed, 2015)
      Introduction: Epidemiological studies suggest that exercise has a tremendous preventative effect on morbidity and premature death, but these findings need to be confirmed by randomised trials. Generation 100 is a randomised, ...
    • A simple algorithm for the identification of clinical COPD phenotypes 

      Burgel, Pierre-Régis; Paillasseur, Jean-Louis; Janssens, Wim; Piquet, Jacques; Ter Riet, Gerben; Garcia-Aymerich, Judith; Cosio, Borja; Bakke, Per S.; Puhan, Milo A.; Langhammer, Arnulf; Alfageme, Inmaculada; Almagro, Pere; Ancochea, Julio; Celli, Bartolomé R.; Casanova, Ciro; de-Torres, Juan P.; Decramer, Marc; Echazarreta, Andrés; Esteban, Cristobal; Punter, Rosa Mar Gomez; Han, Meilan K.; Johannessen, Ane; Kaiser, Bernhard; Lamprecht, Bernd; Lange, Peter; Leivseth, Linda; Marin, Jose M.; Martin, Francis; Martinez-Camblor, Pablo; Miravitlles, Marc; Oga, Toru; Ramírez, Ana Sofia; Sin, Don D.; Sobradillo, Patricia; Soler-Cataluña, Juan J.; Turner, Alice M.; Rivera, Francisco Javier Verdu; Soriano, Joan B.; Roche, Nicolas (Journal article; Peer reviewed, 2017)
      This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses. Data from 2409 COPD patients of French/Belgian COPD ...
    • A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study 

      Markaki, Maria Dorothea Haaberg; Tsamardinos, Ioannis; Langhammer, Arnulf; Lagani, Vincenzo; Hveem, Kristian; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2018)
      Lung cancer causes >1·6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population ...
    • Adiposity and asthma in adults: a bidirectional Mendelian randomization analysis of the HUNT Study 

      Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Kvaløy, Kirsti; Mai, Xiao-Mei (Journal article; Peer reviewed, 2019)
      Background We aimed to investigate the potential causal associations of adiposity with asthma overall, asthma by atopic status or by levels of symptom control in a large adult population and stratified by sex. We also ...
    • Age of menarche is associated with knee joint replacement due to primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register) 

      Hellevik, Alf Inge; Nordsletten, Lars; Johnsen, Marianne Bakke; Fenstad, Anne Marie; Furnes, Ove; Storheim, Kjersti; Zwart, John-Anker; Flugsrud, Gunnar B; Langhammer, Arnulf (Journal article; Peer reviewed, 2017)
      Objective To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) ...
    • Anti-osteoporosis drug use: too little, too much, or just right? The HUNT study, Norway 

      Hoff, Mari; Skurtveit, Svetlana; Meyer, Haakon E; Langhammer, Arnulf; Søgaard, Anne-Johanne; Syversen, Unni; Skovlund, Eva; Abrahamsen, Bo; Forsmo, Siri; Schei, Berit (Journal article; Peer reviewed, 2018)
      Summary Use of anti-osteoporotic drugs (AODs) was examined in a Norwegian population 50–85 years. Among them with Fracture Risk Assessment Tool (FRAX) score for major osteoporotic fracture ≥ 20, 25% of the women and 17% ...
    • The association between normal lung function and peak oxygen uptake in patients with exercise intolerance and coronary artery disease 

      Rasch-Halvorsen, Øystein; Hassel, Erlend; Brumpton, Ben Michael; Jenssen, Haldor; Spruit, Martijn A.; Langhammer, Arnulf; Steinshamn, Sigurd Loe (Peer reviewed; Journal article, 2020)
      In coronary artery disease (CAD), exercise intolerance with reduced oxygen uptake at peak exercise (VO2peak) is assumed to primarily reflect cardiovascular limitation. However, oxygen transport and utilization depends on ...
    • Association between pulmonary function and peak oxygen uptake in elderly: the Generation 100 study 

      Hassel, Erlend; Stensvold, Dorthe; Halvorsen, Thomas; Wisløff, Ulrik; Langhammer, Arnulf; Steinshamn, Sigurd Loe (Peer reviewed; Journal article, 2015)
      Background Although reduced function of the respiratory system limits peak oxygen uptake in diseases affecting the lungs or airways, the healthy respiratory system is thought to have a spare capacity for oxygen transport ...
    • Associations of asthma and asthma control with atrial fibrillation risk: Results from the Nord-Trøndelag health study (HUNT) 

      Cepelis, Aivaras; Brumpton, Ben Michael; Malmo, Vegard; Laugsand, Lars Erik; Loennechen, Jan Pål; Ellekjær, Hanne; Langhammer, Arnulf; Janszky, Imre; Strand, Linn B (Journal article; Peer reviewed, 2018)
      Importance Asthma, a chronic inflammatory airway disease, and atrial fibrillation (AF) share several common pathophysiological mechanisms. Research on the association between asthma and atrial fibrillation is lacking, ...
    • Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study 

      Sun, Yi-Qian; Langhammer, Arnulf; Wu, Chunsen; Skorpen, Frank; Chen, Yue; Nilsen, Tom Ivar Lund; Romundstad, Pål Richard; Mai, Xiao-Mei (Journal article, 2017)
      Background: Previous prospective studies have shown inconsistent associations between serum 25-hydroxyvitamin D [25(OH)D] level and lung cancer incidence. The aim of the present study was to explore the associations of ...
    • Asthma, asthma control and risk of ischemic stroke: The HUNT study 

      Cepelis, Aivaras; Brumpton, Ben Michael; Laugsand, Lars Erik; Langhammer, Arnulf; Janszky, Imre; Strand, Linn B (Journal article; Peer reviewed, 2019)
      Background: Asthma, a chronic inflammatory airway disease, shares common pathophysiological mechanisms with ischemic stroke. The aim of the study is to assess the association between asthma, levels of asthma control and ...
    • Cancer patients' participation in population-based health surveys: Findings from the HUNT studies Cancer 

      Fosså, Sophie Dorothea; Dahl, Alv A; Langhammer, Arnulf; Weedon-Fekjær, Harald (Peer reviewed; Journal article, 2015)
      Background:The magnitude of participation bias due to non‑participation should be considered for cancer patients invited to population‑based surveys. We studied participation rates among persons with and without cancer in ...
    • Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations 

      Midttun, Øivind; Theofylaktopoulou, Despoina; Mccann, Adrian; Fanidi, Anouar; Muller, David C.; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao-Ou; Xiang, Yong-Bing; Prentice, Ross; Thomson, Cynthia A.; Pettinger, Mary; Giles, Graham G.; Hodge, Allison; Cai, Qiuyin; Blot, William J.; Wu, Jie; Johansson, Mikael; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Sesso, Howard D.; Gaziano, J. Michael; Buring, Julie E.; Lee, I-Min; Severi, Gianluca; Zhang, Xuehong; Han, Jiali; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Yuan, Jian-Min; Butler, Lesley M.; Koh, Woon-Puay; Wang, Renwei; Gao, Yu-Tang; Ericson, Ulrika; Sonestedt, Emily; Ziegler, Regina G.; Freedman, Neal D.; Visvanathan, Kala; Jones, Miranda R.; Relton, Caroline; Brennan, Paul; Johansson, Mattias; Ueland, Per Magne (Journal article; Peer reviewed, 2017)
      Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the ...
    • Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3) 

      Larose, Tricia L; Guida, Florence; Anouar, Fanidi; Langhammer, Arnulf; Hveem, Kristian; Stevens, Victoria L.; Jacobs, Eric J.; Smith-Warner, Stephanie A.; Giovannucci, Edward; Albanes, Demetrius; Weinstein, Stephanie J.; Freedman, Neal D.; Prentice, Ross; Pettinger, Mary; Thomson, Cynthia A.; Cai, Qiuyin; Wu, Jie; Blot, William J; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Wilkens, Lynne R.; Haiman, Christopher A.; Zhang, Xuehong; Stampfer, Meir J; Hodge, Allison M.; Giles, Graham G.; Severi, Gianluca; Johansson, Mikael; Grankvist, Kjell; Wang, Renwei; Yuan, Jian-Min; Gao, Yu-Tang; Koh, Woon-Puay; Shu, Xiao-Ou; Zheng, Wei; Xiang, Yong-Bing; Li, Honglan; Lan, Qing; Visvanathan, Kala; Hoffman Bolton, Judith; Ueland, Per Magne; Midttun, Øivind; Caporaso, Neil; Purdue, Mark; Sesso, Howard D.; Buring, Julie E.; Lee, I-Min; Gaziano, J. Michael; Manjer, Jonas; Brunnström, Hans; Brennan, Paul; Johansson, Mattias (Journal article; Peer reviewed, 2018)
      Background Self-reported smoking is the principal measure used to assess lung cancer risk in epidemiological studies. We evaluated if circulating cotinine—a nicotine metabolite and biomarker of recent tobacco exposure—provides ...
    • Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: Nested case-control study within Lung Cancer Cohort Consortium 

      Muller, David C.; Larose, Tricia L; Hodge, Allison; Guida, Florence; Langhammer, Arnulf; Grankvist, Kjell; Meyer, Klaus; Cai, Qiuyin; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Albanes, Demetrius; Giles, Graham G.; Sesso, Howard D.; Lee, I-Min; Gaziano, J. Michael; Yuan, Jian-Min; Hoffman Bolton, Judith; Buring, Julie E.; Visvanathan, Kala; Le Marchand, Loic; Purdue, Mark P.; Caporaso, Neil E.; Midttun, Øivind; Ueland, Per Magne; Prentice, Ross L.; Weinstein, Stephanie J.; Stevens, Victoria L.; Zheng, Wei; Blot, William J.; Shu, Xiao-Ou; Zhang, Xuehong; Xiang, Yong-Bing; Koh, Woon-Puay; Hveem, Kristian; Thomson, Cynthia A.; Pettinger, Mary; Engström, Gunnar; Brunnström, Hans; Milne, Roger L.; Stampfer, Meir J.; Han, Jiali; Johansson, Mikael; Brennan, Paul; Severi, Gianluca; Johansson, Mattias (Journal article; Peer reviewed, 2019)
      Objectives: Inflammation may play an important role in lung cancer pathogenesis. Previous studies have suggested an association between C-reactive protein (CRP) as a marker of inflammation, and risk of lung cancer, but ...
    • Circulating markers of cellular immune activation in pre-diagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3) 

      Huang, Joyce Yongxu; Larose, Tricia L; Luu, Hung N; Wang, Renwei; Fanidi, Anouar; Alcala, Karine; Stevens, Victoria L.; Weinstein, Stephanie J.; Albanes, Demetrius; Caporaso, Neil E.; Purdue, Mark P.; Ziegler, Regina G.; Freedman, Neal D.; Lan, Qing; Prentice, Ross L.; Pettinger, Mary; Thomson, Cynthia A.; Cai, Qiuyin; Wu, Jie; Blot, William J.; Shu, Xiao-Ou; Zheng, Wei; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loïc; Wilkens, Lynn R; Haiman, Christopher A.; Zhang, Xuehong; Stampfer, Meir J.; Han, Jiali; Giles, Graham G.; Hodge, Allison M.; Severi, Gianluca; Johansson, Mikael; Grankvist, Kjell; Langhammer, Arnulf; Hveem, Kristian; Xiang, Yong-Bing; Li, Hong-Lan; Gao, Yu-Tang; Visvanathan, Kala; Ueland, Per Magne; Midttun, Øivind; Ulvik, Arve; Buring, Julie E.; Lee, I-Min; Sesso, Howard D.; Gaziano, J. Michael; Manjer, Jonas; Relton, Caroline; Koh, Woon-Puay; Brennan, Paul; Johansson, Mattias; Yuan, Jian-Min (Journal article; Peer reviewed, 2019)
      Cell‐mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) ...
    • Cod liver oil intake and incidence of asthma in Norwegian adults-the HUNT study 

      Mai, Xiao-Mei; Langhammer, Arnulf; Chen, Yue; Camargo, Carlos Arthuro (Journal article; Peer reviewed, 2013)
      Background Cod liver oil is an important source of vitamin D, but also contains other fat-soluble components such as vitamin A. Before 1999, the cod liver oil formula in Norway contained a high concentration of vitamin A ...
    • Cross-Sectional and Prospective Cohort Study of Serum 25-Hydroxyvitamin D Level and Obesity in Adults 

      Mai, Xiao-Mei; Chen, Yue; Camargo, Carlos Arthuro; Langhammer, Arnulf (Journal article; Peer reviewed, 2012)
      Experimental studies suggest that vitamin D modulates the activity of adipocytes. The authors examined baseline serum 25-hydroxyvitamin D (25(OH)D) level in relation to prevalent and cumulative incident obesity in Norway. ...
    • Diagnostic labelling and implications for health, a population-based study 

      Jørgensen, Pål (Doctoral theses at NTNU;2018:8, Doctoral thesis, 2018)
      NORSK POPULÆRVITENSKAPELIG SAMMENDRAG Helsemessige konsekvenser av kjennskap til egen diagnose – en populasjonsbasert studie Epidemien av «ikke-smittsomme sykdommer» og livsstilssykdommer blir gjerne sett på som den ...
    • Effekt av livsstilsfaktorer som røyking, kaffe- og tekonsum på beinmineraltetthet (BMD) i en prospektiv studie 

      Oskal, Kristin Bekkelund (Master thesis, 2013)
      Målsetting: Å beskrive effekten av røyking og konsum av koffeinholdige drikker som kaffe og te på beinmineraltetthet (BMD) i hofter og korsrygg hos kvinner  og menn 50-79 år. Materiale og metode: ...