Now showing items 1-20 of 113

    • A randomised controlled study of the long-term effects of exercise training on mortality in elderly people: Study protocol for the generation 100 study 

      Stensvold, Dorthe; Viken, Hallgeir; Rognmo, Øivind; Skogvoll, Eirik; Steinshamn, Sigurd Loe; Vatten, Lars Johan; Coombes, Jeff S; Anderssen, Sigmund Alfred; Magnussen, Jon; Ingebrigtsen, Jan Erik; Singh, Maria A Fiatarone; Langhammer, Arnulf; Støylen, Asbjørn; Helbostad, Jorunn L.; Wisløff, Ulrik (Journal article; Peer reviewed, 2015)
      Introduction: Epidemiological studies suggest that exercise has a tremendous preventative effect on morbidity and premature death, but these findings need to be confirmed by randomised trials. Generation 100 is a randomised, ...
    • A simple algorithm for the identification of clinical COPD phenotypes 

      Burgel, Pierre-Régis; Paillasseur, Jean-Louis; Janssens, Wim; Piquet, Jacques; Ter Riet, Gerben; Garcia-Aymerich, Judith; Cosio, Borja; Bakke, Per S.; Puhan, Milo A.; Langhammer, Arnulf; Alfageme, Inmaculada; Almagro, Pere; Ancochea, Julio; Celli, Bartolomé R.; Casanova, Ciro; de-Torres, Juan P.; Decramer, Marc; Echazarreta, Andrés; Esteban, Cristobal; Punter, Rosa Mar Gomez; Han, Meilan K.; Johannessen, Ane; Kaiser, Bernhard; Lamprecht, Bernd; Lange, Peter; Leivseth, Linda; Marin, Jose M.; Martin, Francis; Martinez-Camblor, Pablo; Miravitlles, Marc; Oga, Toru; Ramírez, Ana Sofia; Sin, Don D.; Sobradillo, Patricia; Soler-Cataluña, Juan J.; Turner, Alice M.; Rivera, Francisco Javier Verdu; Soriano, Joan B.; Roche, Nicolas (Journal article; Peer reviewed, 2017)
      This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses. Data from 2409 COPD patients of French/Belgian COPD ...
    • A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study 

      Markaki, Maria Dorothea Haaberg; Tsamardinos, Ioannis; Langhammer, Arnulf; Lagani, Vincenzo; Hveem, Kristian; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2018)
      Lung cancer causes >1·6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population ...
    • Adiposity and asthma in adults: a bidirectional Mendelian randomization analysis of the HUNT Study 

      Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Kvaløy, Kirsti; Mai, Xiao-Mei (Journal article; Peer reviewed, 2019)
      Background We aimed to investigate the potential causal associations of adiposity with asthma overall, asthma by atopic status or by levels of symptom control in a large adult population and stratified by sex. We also ...
    • Age of menarche is associated with knee joint replacement due to primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register) 

      Hellevik, Alf Inge; Nordsletten, Lars; Johnsen, Marianne Bakke; Fenstad, Anne Marie; Furnes, Ove; Storheim, Kjersti; Zwart, John-Anker; Flugsrud, Gunnar B; Langhammer, Arnulf (Journal article; Peer reviewed, 2017)
      Objective To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) ...
    • Age-of-onset information helps identify 76 genetic variants associated with allergic disease 

      Ferreira, Manuel A R; Vonk, Judith M.; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D.; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Lu, Yi; Grosche, Sarah; Ruschendorf, Franz; Granell, Raquel; Brumpton, Ben Michael; Fritsche, Lars; Bhatta, Laxmi; Gabrielsen, Maiken Elvestad; Nielsen, Jonas Bille; Zhou, Wei; Hveem, Kristian; Langhammer, Arnulf; Holmen, Oddgeir; Løset, Mari; Abecasis, Goncalo; Willer, Cristen J.; Emami, Nima C.; Cavazos, Taylor B.; Witte, John S.; Szwajda, Agnieszka; 23andMe Research Team, ,; collaborators of SHARE study, ,; Hinds, David A.; Hubner, Norbert; Weidinger, Stephan; Magnusson, Patrik KE; Jorgenson, Eric; Karlsson, Robert; Paternoster, Lavinia; Boomsma, Dorret I.; Almqvist, Catarina; Lee, Young-Ae; Koppelman, Gerard H.; Esparza-Gordillo, Jorge; Hummel, Oliver; Hottenga, Jouke-Jan; Willemsen, Gonneke; Rodríguez, Elke; Hotze, Melanie; Franke, Andre; Matheson, Melanie C.; Dharmage, Shyamali Chandrika; Arnold, Andreas; Homuth, Georg; Schmidt, Carsten O; Thompson, Philip J.; Martin, Nicholas G; Duffy, David L.; Novak, Natalija; Schulz, Holger; Karrasch, Stefan; Gieger, Christian; Strauch, Konstantin; Melles, Ronald B (Peer reviewed; Journal article, 2020)
      Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which ...
    • Airway Symptoms among Farmers in Central Norway. A Comparative Study of Risks. The HUNT Study 

      Slåstad, Siri; Svendsen, Kristin V Hirsch; Langhammer, Arnulf (Peer reviewed; Journal article, 2022)
      Objectives The objective of this study was to compare the risk of developing respiratory symptoms in farmers and other occupational groups over a period of 11 to 23 years. Methods The study includes data from ...
    • Anti-osteoporosis drug use: too little, too much, or just right? The HUNT study, Norway 

      Hoff, Mari; Skurtveit, Svetlana; Meyer, Haakon E; Langhammer, Arnulf; Søgaard, Anne-Johanne; Syversen, Unni; Skovlund, Eva; Abrahamsen, Bo; Forsmo, Siri; Schei, Berit (Journal article; Peer reviewed, 2018)
      Summary Use of anti-osteoporotic drugs (AODs) was examined in a Norwegian population 50–85 years. Among them with Fracture Risk Assessment Tool (FRAX) score for major osteoporotic fracture ≥ 20, 25% of the women and 17% ...
    • Assessing the role of genome-wide DNA methylation between smoking and risk of lung cancer using repeated measurements: the HUNT Study 

      Sun, Yi-Qian; Richmond, Rebecca C.; Suderman, Matthew; Min, Josine L; Battram, Thomas; Flatberg, Arnar; Beisvag, Vidar; Nøst, Therese Haugdahl; Guida, Florence; Jiang, Lin; Wahl, Sissel Gyrid Freim; Langhammer, Arnulf; Skorpen, Frank; Walker, Rosie M; Bretherick, Andrew D; Zeng, Yanni; Chen, Yue; Johansson, Mattias; Sandanger, Torkjel M; Relton, Caroline L; Mai, Xiao-Mei (Peer reviewed; Journal article, 2021)
      Background: It is unclear if smoking-related DNA methylation represents a causal pathway between smoking and risk of lung cancer. We sought to identify novel smoking-related DNA methylation sites in blood, with repeated ...
    • Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study 

      Nethander, Maria; Coward, Eivind; Reimann, Ene; Grahnemo, Louise; Gabrielsen, Maiken Elvestad; Wibom, Carl; Nelis, Mari; Milani, Lili; Esko, Tõnu; Metspalu, Andres; Mägi, Reedik; Funck-Brentano, Thomas; Hoff, Mari; Langhammer, Arnulf; Pettersson-Kymmer, Ulrika; Hveem, Kristian; Ohlsson, Claes (Peer reviewed; Journal article, 2022)
      Hip fracture is the clinically most important fracture, but the genetic architecture of hip fracture is unclear. Here, we perform a large-scale hip fracture genome-wide association study meta-analysis and Mendelian ...
    • The association between normal lung function and peak oxygen uptake in patients with exercise intolerance and coronary artery disease 

      Rasch-Halvorsen, Øystein; Hassel, Erlend; Brumpton, Ben Michael; Jenssen, Haldor; Spruit, Martijn A.; Langhammer, Arnulf; Steinshamn, Sigurd Loe (Peer reviewed; Journal article, 2020)
      In coronary artery disease (CAD), exercise intolerance with reduced oxygen uptake at peak exercise (VO2peak) is assumed to primarily reflect cardiovascular limitation. However, oxygen transport and utilization depends on ...
    • Association between Pelvic Floor Disorders and Bone Mineral Density: Findings from the HUNT study 

      Aspli, Sigrid; Aalberg Vikjord, Sigrid Anna; Langhammer, Arnulf; Horn, Julie (Master thesis, 2021)
      Sammendrag Mål: Målet med studien var å undersøke sammenhengen mellom bekkenbunnssvikt (nedfall, urininkontinens og analinkontinens) og beintetthet. Studiedesign: Vi gjennomførte en tverrsnittsstudie av 6,809 kvinner som ...
    • Association between pelvic floor disorders and bone mineral density: Findings from the HUNT study 

      Aspli, Sigrid; Vikjord, Sigrid Anna Aalberg; Langhammer, Arnulf; Horn, Julie (Peer reviewed; Journal article, 2022)
      Objectives To examine the association between pelvic floor disorders (pelvic organ prolapse, urinary incontinence and anal incontinence) and bone mineral density (BMD). Study design: A cross-sectional study of 6809 ...
    • Association between pulmonary function and peak oxygen uptake in elderly: the Generation 100 study 

      Hassel, Erlend; Stensvold, Dorthe; Halvorsen, Thomas; Wisløff, Ulrik; Langhammer, Arnulf; Steinshamn, Sigurd Loe (Peer reviewed; Journal article, 2015)
      Background Although reduced function of the respiratory system limits peak oxygen uptake in diseases affecting the lungs or airways, the healthy respiratory system is thought to have a spare capacity for oxygen transport ...
    • Associations of asthma and asthma control with atrial fibrillation risk: Results from the Nord-Trøndelag health study (HUNT) 

      Cepelis, Aivaras; Brumpton, Ben Michael; Malmo, Vegard; Laugsand, Lars Erik; Loennechen, Jan Pål; Ellekjær, Hanne; Langhammer, Arnulf; Janszky, Imre; Strand, Linn B (Journal article; Peer reviewed, 2018)
      Importance Asthma, a chronic inflammatory airway disease, and atrial fibrillation (AF) share several common pathophysiological mechanisms. Research on the association between asthma and atrial fibrillation is lacking, ...
    • Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study 

      Sun, Yi-Qian; Langhammer, Arnulf; Wu, Chunsen; Skorpen, Frank; Chen, Yue; Nilsen, Tom Ivar Lund; Romundstad, Pål Richard; Mai, Xiao-Mei (Journal article, 2017)
      Background: Previous prospective studies have shown inconsistent associations between serum 25-hydroxyvitamin D [25(OH)D] level and lung cancer incidence. The aim of the present study was to explore the associations of ...
    • Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study 

      Jiang, Lin; Sun, Yi-Qian; Langhammer, Arnulf; Brumpton, Ben Michael; Chen, Yu; Nilsen, Tom Ivar Lund; Leivseth, Linda; Wahl, Sissel Gyrid Freim; Mai, Xiao-Mei (Peer reviewed; Journal article, 2021)
      Large prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited. We followed up 62,791 cancer-free Norwegian adults from 1995–1997 to 2017. Self-reported ...
    • Asthma, asthma control and risk of ischemic stroke: The HUNT study 

      Cepelis, Aivaras; Brumpton, Ben Michael; Laugsand, Lars Erik; Langhammer, Arnulf; Janszky, Imre; Strand, Linn B (Journal article; Peer reviewed, 2019)
      Background: Asthma, a chronic inflammatory airway disease, shares common pathophysiological mechanisms with ischemic stroke. The aim of the study is to assess the association between asthma, levels of asthma control and ...
    • The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium 

      Guida, Florence; Tan, VY; Smith-Byrne, K; Alcala, Karine; Langenberg, C; Butterworth, AS; Surendran, P; Achaintre, David; Adamski, P; Bergmann, MM; Bull, CJ; Dahm, CC; Gicquiau, Audrey; Giles, GG; Gunter, MJ; Haller, T; Langhammer, Arnulf; Larose, TL; Ljungberd, B; Metspalu, A; Milne, RL; Muller, DC; Nøst, Therese Haugdahl; Sørgjerd, Elin Pettersen; Prehn, C; Riboli, E; Rinaldi, S; Rothwell, JA; Scalbert, A.; Severi, G; Sieri, S; Vermeulen, R; Vincent, EE; Waldenberger, M; Timpson, NJ; Johansson, M (Journal article; Peer reviewed, 2021)
    • The blood proteome of imminent lung cancer diagnosis 

      Albanes, Demetrius; Alcala, Karine; Alcala, Nicolas; Amos, Christopher I.; Arslan, Alan A.; Bassett, Julie K.; Brennan, Paul; Cai, Qiuyin; Chen, Chu; Feng, Xiaoshuang; Freedman, Neal D.; Guida, Florence; Hung, Rayjean J.; Hveem, Kristian; Johansson, Mikael; Johansson, Mattias; Koh, Woon-Puay; Langhammer, Arnulf; Milne, Roger L.; Muller, David; Onwuka, Justina; Sørgjerd, Elin Pettersen; Robbins, Hilary A.; Sesso, Howard D.; Severi, Gianluca; Shu, Xiao-Ou; Sieri, Sabina; Smith-Byrne, Karl; Stevens, Victoria; Tinker, Lesley; Tjønneland, Anne; Visvanathan, Kala; Wang, Ying; Wang, Renwei; Weinstein, Stephanie; Yuan, Jian-Min; Zahed, Hana; Zhang, Xuehong; Zheng, Wei (Peer reviewed; Journal article, 2023)
      Identification of risk biomarkers may enhance early detection of smoking-related lung cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most three years before diagnosis in 731 smoking-matched ...