Blar i NTNU Open på forfatter "Klepstad, Pål"
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Acute kidney injury in COVID-19 patients in Intensive Care Unit
Aukland, Eirik Aasen (Master thesis, 2021) -
Acute kidney injury in intensive care patients: Incidence, time course, and risk factors
Mo, Skule; Bjelland, Thor Wilhelm; Nilsen, Tom Ivar Lund; Klepstad, Pål (Peer reviewed; Journal article, 2022)Background Acute kidney injury (AKI) is frequent and influences the prognosis of intensive care unit (ICU) patients. The aim of this study was to estimate the incidence, time-course, risk factors, and mortality of AKI ... -
Acute kidney injury in patients with COVID-19 in the intensive care unit: Evaluation of risk factors and mortality in a national cohort
Aukland, Eirik Aasen; Klepstad, Pål; Aukland, Stein Magnus; Zamanzad Ghavidel, Fatemeh; Buanes, Eirik Alnes (Peer reviewed; Journal article, 2022)Objectives Acute kidney injury (AKI) is a frequent complication among critical ill patients with COVID-19, but the actual incidence is unknown as AKI-incidence varies from 25% to 89% in intensive care unit (ICU) populations. ... -
An in-hospital clinical care pathway with integrated decision support for cancer pain management reduced pain intensity and needs for hospital stay
Løhre, Erik Torbjørn; Thronæs, Morten; Brunelli, Cinzia; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2019)Purpose A clinical care pathway for pain management in a palliative care unit was studied with outcomes related to patients, physicians, and health care service. Mandatory use of patient-reported outcome measures (PROMs) ... -
Antibiotic Therapy in Integrated Oncology and Palliative Cancer Care: An Observational Study
Moen, Martine Kjølberg; Løhre, Erik T; Jakobsen, Gunnhild; Thronæs, Morten; Klepstad, Pål (Peer reviewed; Journal article, 2022)Simple Summary Approximately one-quarter of the patients with advanced cancer acutely admitted to the Palliative Care Unit at St. Olav’s University Hospital received intravenous antibiotics. We observed that physiological ... -
Aspects of assessment, classification and treatment of cancer pain
Løhre, Erik Torbjørn (Doctoral theses at NTNU;2020:31, Doctoral thesis, 2020) -
Bedside dressing changes for open abdomen in the intensive care unit is safe and time and staff efficient
Seternes, Arne; Fasting, Sigurd; Klepstad, Pål; Mo, Skule; Dahl, Torbjørn; Bjørck, Martin; Wibe, Arne (Journal article; Peer reviewed, 2016)Background Patients with an open abdomen (OA) treated with temporary abdominal closure (TAC) need multiple surgical procedures throughout the hospital stay with repeated changes of the vacuum-assisted closure device (VAC ... -
Benefits of Study Participation for Patients with Advanced Cancer Receiving Radiotherapy: A Prospective Observational Study
Bye, Asta; Bjerkeset, Ellen; Stensheim, Hanne; Loge, Jon Håvard; Hjermstad, Marianne Jensen; Klepstad, Pål; Habberstad, Ragnhild H; Kaasa, Stein; Aass, Nina Kathrine (Peer reviewed; Journal article, 2022)Background: Patients with advanced cancer and bone metastases may have unmet palliative care (PC) needs that go unnoticed during clinical oncological practice. This observational study describes interventions that were ... -
Breakthrough and Episodic Cancer Pain from a Palliative Care Perspective
Løhre, Erik Torbjørn; Jakobsen, Gunnhild; Solheim, Tora Skeidsvoll; Klepstad, Pål; Thronæs, Morten (Peer reviewed; Journal article, 2023)Cancer pain intensity (PI) fluctuates, but the relationship between pain flares and background pain with respect to pain management is not settled. We studied how flare and background PIs corresponded with treatment results ... -
Breakthrough cancer pain in 2020
Løhre, Erik T; Thronæs, Morten; Klepstad, Pål (Peer reviewed; Journal article, 2020)Purpose of review An overview on breakthrough cancer pain (BTCP), including inherent limitations of the terminology, assessment, clinical presentation, and treatment options. Recent findings The estimated prevalence ... -
Can variability in the effect of opioids on refractory breathlessness be explained by genetic factors?
Currow, David C.; Quinn, Stephen; Ekström, Magnus; Kaasa, Stein; Johnson, Miriam J.; Somogyi, Andrew A.; Klepstad, Pål (Journal article; Peer reviewed, 2015)Objectives: Opioids modulate the perception of breathlessness with a considerable variation in response, with poor correlation between the required opioid dose and symptom severity. The objective of this hypothesis-generating, ... -
Cancer induced bone pain
Habberstad, Ragnhild (Doctoral theses at NTNU;2024:38, Doctoral thesis, 2024)Bone metastases causing cancer induced bone pain (CIBP) is one of the most frequent reasons for pain in patients with cancer. Although pain is a common consequence of bone metastases, not all patients with bone metastases ... -
Changes in peripheral arterial blood pressure after resuscitative endovascular balloon occlusion of the aorta (REBOA) in non-traumatic cardiac arrest patients
Brede, Jostein Rødseth; Skjærseth, Eivinn Årdal; Klepstad, Pål; Nordseth, Trond; Krüger, Andreas (Peer reviewed; Journal article, 2021)Background Resuscitative endovascular balloon occlusion of the aorta (REBOA) may be an adjunct treatment to cardiopulmonary resuscitation (CPR). Aortic occlusion may increase aortic pressure and increase the coronary ... -
Characteristics of circulatory failure after out-of-hospital cardiac arrest: A prospective cohort study
Langeland, Halvor; Bergum, Daniel; Løberg, Magnus; Bjørnstad, Knut; Skaug, Thomas Renhult; Nordseth, Trond; Klepstad, Pål; Skjaervold, Nils Kristian (Peer reviewed; Journal article, 2022)Background Circulatory failure after out-of-hospital cardiac arrest (OHCA) as part of the postcardiac arrest syndrome (PCAS) is believed to be caused by an initial myocardial depression that later subsides into a superimposed ... -
Circulatory characterization of the post-cardiac arrest syndrome: A study of the inflammatory response and the circulatory failure after out-of-hospital cardiac arrest
Langeland, Halvor J. B. (Doctoral theses at NTNU;2022:116, Doctoral thesis, 2022)Norsk sammendrag EN STUDIE AV BETENNELSESREAKSJONEN OG SIRKULASJONSSVIKTEN ETTER HJERTESTANS UTENFOR SYKEHUS Det har lenge vært kjent at hjertestans fører til en voldsom betennelsesreaksjon, som igjen fører til en dødelig ... -
Circulatory trajectories after out-of-hospital cardiac arrest: a prospective cohort study
Langeland, Halvor; Langeland, Halvor; Bergum, Daniel; Nordseth, Trond; Løberg, Magnus; Skaug, Thomas; Skaug, Thomas Renhult; Bjørnstad, Knut; Bjørnstad, Knut; Gundersen, Ørjan; Skjaervold, Nils Kristian; Klepstad, Pål (Peer reviewed; Journal article, 2021)Background: Circulatory failure frequently occurs after out-of-hospital cardiac arrest (OHCA) and is part of postcardiac arrest syndrome (PCAS). The aim of this study was to investigate circulatory disturbances in PCAS by ... -
Clinical Predictors for Analgesic Response to Radiotherapy in Patients with Painful Bone Metastases
Habberstad, Ragnhild H; Frøseth, Trude Camilla Salvesen; Aass, Nina Kathrine; Bjerkeset, Gunnhild; Abramova, Tatiana Mikhailovna; Garcia-Alonso, Elena; Caputo, Mariangela; Rossi, Romina; Boland, Jason W.; Brunelli, Cinzia; Lund, Jo-Åsmund; Kaasa, Stein; Klepstad, Pål (Peer reviewed; Journal article, 2021)Background Radiotherapy (RT) reduces pain in about 60% of patients with painful bone metastases, leaving many patients without clinical benefit. This study assesses predictors for RT effectiveness in patients with painful ... -
Clinically significant drug-drug interactions involving medications used for symptom control in patients with advanced malignant disease: A systematic review
Kotlinska-Lemieszek, Aleksandra; Klepstad, Pål; Haugen, Dagny Faksvåg (Journal article; Peer reviewed, 2019)Context Most patients with advanced malignant disease need to take several drugs to control symptoms. This treatment raises risks of serious adverse effects and drug-drug interactions (DDIs). Objectives To identify ... -
Clinically significant drug–drug interactions involving opioid analgesics used for pain treatment in patients with cancer: A systematic review
Kotlinska-Lemieszek, Aleksandra; Klepstad, Pål; Haugen, Dagny Faksvåg (Journal article; Peer reviewed, 2015-09-16)Opioids are the most frequently used drugs to treat pain in cancer patients. In some patients, however, opioids can cause adverse effects and drug–drug interactions. No advice concerning the combination of opioids and other ... -
Computerized Decision Support Systems for Evaluation and Treatment of Pain and Other Symptoms in Cancer Patients
Raj, Sunil Xavier (Doctoral theses at NTNU;2018:411, Doctoral thesis, 2018)Norsk sammendrag - Summary in Norwegian Det er kjent at kreftpasienter har en rekke symptomer på grunn av kreftsykdommen. Det er anslått at omtrent 30-50% av kreftpasientene har kreftsmerter som ikke er tilfredsstillende ...