Browsing NTNU Open by Author "Iversen, Ann-Charlotte"
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A Study of Toll-like Receptors in Trophoblasts, and the Influence of Cytomegalovirus Infection
Stødle, Guro Kristine Sannerud (Master thesis, 2012)Toll-like receptors (TLRs) act as sensors against invading pathogens and endogenous danger signals, and are critical mediators of inflammatory immune responses. During pregnancy, intrauterine activation of TLRs might evoke ... -
Association between gestational hypertension and risk of cardiovascular disease among 617 589 Norwegian women
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Nygård, Ottar; Iversen, Ann-Charlotte; Daltveit, Anne Kjersti (Journal article; Peer reviewed, 2018)Background Preeclampsia and gestational hypertension (GH) are the most common hypertensive pregnancy disorders. Preeclampsia has been linked to increased risk of cardiovascular disease (CVD), but a similar association for ... -
Changing patterns of cytomegalovirus seroprevalence among pregnant women in Norway between 1995 and 2009 examined in the Norwegian Mother and Child Cohort Study and two cohorts from Sør-Trøndelag County: a cross-sectional study
Odland, Maria Lisa; Strand, Kristin Melheim; Nordbø, Svein Arne; Forsmo, Siri; Ausgtulen, Rigmor; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2013)Objectives: To examine cytomegalovirus (CMV) seroprevalence and associated risk factors for CMV seropositivity in pregnant Norwegian women. Design: Cross-sectional study. Setting: The Norwegian Mother and Child ... -
Cytomegalovirus antibody status at 17 - 18 weeks of gestation and preeclampsia: a case-control study of pregnant women in Norway
Strand, Kristin Melheim; Odland, Maria Lisa; Iversen, Ann-Charlotte; Nordbø, Svein Arne; Vik, Torstein; Austgulen, Rigmor (Journal article; Peer reviewed, 2012)Objective To assess the association between maternal cytomegalovirus (CMV) antibodies in mid-pregnancy and preeclampsia. Design Nested case–control study. Setting Pregnancies registered in the Norwegian Mother and ... -
Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia
Tangerås, Line Haugstad; Austdal, Marie; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)Objective—Gestational hypertension and preeclampsia involve dysregulated maternal inflammatory responses to pregnancy, but whether such responses differ between the disorders has not been determined. We aimed to investigate ... -
First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study
Austdal, Marie; Tangerås, Line Haugstad; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost (Journal article; Peer reviewed, 2015)Hypertensive disorders of pregnancy, including preeclampsia, are major contributors to maternal morbidity. The goal of this study was to evaluate the potential of metabolomics to predict preeclampsia and gestational ... -
Functional Toll-like receptors in primary first-trimester trophoblasts
Tangerås, Line; Stødle, Guro; Olsen, Guro Dalheim; Leknes, Ann-Helen; Gundersen, Astrid; Skei, Bente; Vikdal, Anne Jorunn; Ryan, Liv; Steinkjer, Bjørg; Myklebost, Merete; Langaas, Mette; Austgulen, Rigmor; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2014)Toll-like receptors (TLRs) are an important part of the body's danger response system and crucial for initiating inflammation in response to cellular stress, tissue damage, and infections. Proper placental development is ... -
Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene
Johnson, Matthew P; Brennecke, Shaun P.; East, Christine; Göring, Harald H H; Kent, Jack W; Dyer, Thomas D.; Said, Joanne M; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Abraham, Lawrence J; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Laivuori, Hannele; Austgulen, Rigmor; Blangero, John; Moses, Eric K (Journal article; Peer reviewed, 2012)Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed a genome-wide association study (GWAS) for preeclampsia in unrelated Australian individuals of Caucasian ancestry ... -
Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Egeland, Grace M.; Nygård, Ottar; Selmer, Randi Marie; Iversen, Ann-Charlotte; Daltveit, Anne Kjersti (Peer reviewed; Journal article, 2019)Background and aim Hypertensive pregnancy disorders are associated with subsequent cardiovascular disease (CVD), but the extent to which this association is explained by shared risk factors is unknown. We aimed to evaluate ... -
Incident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and parity
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Nygård, Ottar; Vollset, Stein Emil; Iversen, Ann-Charlotte; Austgulen, Rigmor; Daltveit, Anne Kjersti (Journal article; Peer reviewed, 2017)Background Preeclampsia is a severe pregnancy disorder often complicated by reduced fetal growth or preterm delivery and is associated with long‐term maternal morbidity and mortality. We aimed to assess the association ... -
Inflammation in Pregnancy – A Study of Pattern Recognition Receptors in Trophoblasts
Tangerås, Line Haugstad (Master thesis, 2011)Normal pregnancy is characterized by a mildly elevated state of inflammation, as a consequence of the woman’s body adapting to the presence of the growing fetus. The placenta is established in early pregnancy, and constitutes ... -
InterPregGen: Genetic studies of pre-eclampsia in three continents
Morgan, Linda; McGinnis, Ralph; Steinthorsdottir, Valgerdur; Syvatova, Gulnara; Zakhidova, Nodira; Lee, Wai Kwong; Iversen, Ann-Charlotte; Magnus, Per; Walker, James; Casas, Juan Pablo; Sultanov, Saidazim; Laivuori, Hannele (Journal article; Peer reviewed, 2014)Pre-eclampsia is a major cause of maternal and fetal mortality in pregnancy. The identification of genetic variants which predispose to pre-eclampsia demands large DNA collections from affected mothers and babies and ... -
Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia
Pabalan, Noel; Jarjanazi, H; Sun, Chen; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)The non-classical major histocompatibility complex, human leukocyte antigen (HLA)-G, plays an important role in pregnancy. HLA-G mediates proper interaction between maternal immune cells and fetal trophoblasts invading the ... -
Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics
Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, ... -
Metabolomic biomarkers in serum and urine in women with preeclampsia
Austdal, Marie; Skråstad, Ragnhild; Gundersen, Astrid; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost (Journal article, 2014)Objective To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis. Methods Urine and serum ... -
Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study
Austdal, Marie (Master thesis, 2012)Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ... -
Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study
Austdal, Marie (Master thesis, 2012)Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ... -
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity
Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ... -
Pathological processes in the uterine wall decidua in preeclampsia and fetal growth restriction
Mundal, Siv Boon (Doctoral theses at NTNU;2020:11, Doctoral thesis, 2020)Sykdomsprosesser i decidua ved svangerskapsforgiftning og føtal veksthemming Morkaken består av en maternell del som utvikles fra livmorveggen (decidua) og en føtal del som er bygget opp av fosterceller (placenta). ... -
Pattern recognition receptor mediated inflammation in placental trophoblasts
Stødle, Guro Sannerud (Doctoral theses at NTNU;2017:324, Doctoral thesis, 2017)Studie av mekanismer for betennelse i morkaken Betennelse (inflammasjon) er en immunrespons som kroppen setter i gang for å beskytte seg mot infeksjoner og vevsskade. Alle mennesker er født med "mønster-gjenkjennende" ...