Browsing NTNU Open by Author "Iversen, Ann-Charlotte"

Now showing items 1-20 of 45

    • A Study of Toll-like Receptors in Trophoblasts, and the Influence of Cytomegalovirus Infection 

      Stødle, Guro Kristine Sannerud (Master thesis, 2012)
      Toll-like receptors (TLRs) act as sensors against invading pathogens and endogenous danger signals, and are critical mediators of inflammatory immune responses. During pregnancy, intrauterine activation of TLRs might evoke ...

    • Association between gestational hypertension and risk of cardiovascular disease among 617 589 Norwegian women 

      Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Nygård, Ottar; Iversen, Ann-Charlotte; Daltveit, Anne Kjersti (Journal article; Peer reviewed, 2018)
      Background Preeclampsia and gestational hypertension (GH) are the most common hypertensive pregnancy disorders. Preeclampsia has been linked to increased risk of cardiovascular disease (CVD), but a similar association for ...

    • Changing patterns of cytomegalovirus seroprevalence among pregnant women in Norway between 1995 and 2009 examined in the Norwegian Mother and Child Cohort Study and two cohorts from Sør-Trøndelag County: a cross-sectional study 

      Odland, Maria Lisa; Strand, Kristin Melheim; Nordbø, Svein Arne; Forsmo, Siri; Ausgtulen, Rigmor; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2013)
      Objectives: To examine cytomegalovirus (CMV) seroprevalence and associated risk factors for CMV seropositivity in pregnant Norwegian women. Design: Cross-sectional study. Setting: The Norwegian Mother and Child ...

    • Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies 

      Silva, Gabriela; Gierman, Lobke; Rakner, Johanne Johnsen; Stødle, Guro; Mundal, Siv Boon; Thaning, Astrid Josefin; Sporsheim, Bjørnar; Elschot, Mattijs; Collett, Karin; Bjørge, Line; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2020)
      Preeclampsia is a hypertensive and inflammatory pregnancy disorder associated with cholesterol accumulation and inflammation at the maternal-fetal interface. Preeclampsia can be complicated with fetal growth restriction ...

    • Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia 

      Dijkstra, Douwe Jan; Lokki, A Inkeri; Gierman, Lobke; Borggreven, Nicole Veronique; van der Keur, Carin; Eikmans, Michael; Gelderman, Kyra Andrea; Laivuori, Hannele; Heinonen, Seppo; Kajantie, Eero Olavi; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Iversen, Ann-Charlotte; van der Hoorn, Marie-Louise P; Trouw, Leendert Adrianus (Peer reviewed; Journal article, 2022)
      Preeclampsia (PE) generally manifests in the second half of pregnancy with hypertension and proteinuria. The understanding of the origin and mechanism behind PE is incomplete, although there is clearly an immune component ...

    • Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond 

      Jarmund, Anders Hagen; Giskeødegård, Guro F.; Ryssdal, Mariell; Steinkjer, Bjørg; Stokkeland, Live Marie; Madssen, Torfinn Støve; Stafne, Signe Nilssen; Stridsklev, Solhild; Moholdt, Trine; Heimstad, Runa Kristine; Vanky, Eszter; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)
      Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity and fetal demands. We performed cytokine profiling of 1149 longitudinal serum ...

    • Cytokine profiling as a measure of immunological development and deviation throughout pregnancy in healthy women and women with PCOS 

      Stokkeland, Live Marie Tobiesen (Doctoral theses at NTNU;2022:183, Doctoral thesis, 2022)
      Norsk sammendrag Cytokinprofilering som mål på immunologiske forandringer gjennom svangerskapet hos friske kvinner og kvinner med PCOS Mors immunsystem tilpasser seg gjennom de ulike fasene av svangerskapet for å sikre ...

    • Cytomegalovirus antibody status at 17 - 18 weeks of gestation and preeclampsia: a case-control study of pregnant women in Norway 

      Strand, Kristin Melheim; Odland, Maria Lisa; Iversen, Ann-Charlotte; Nordbø, Svein Arne; Vik, Torstein; Austgulen, Rigmor (Journal article; Peer reviewed, 2012)
      Objective To assess the association between maternal cytomegalovirus (CMV) antibodies in mid-pregnancy and preeclampsia. Design Nested case–control study. Setting Pregnancies registered in the Norwegian Mother and ...

    • Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies 

      Rakner, Johanne Johnsen; Silva, Gabriela; Mundal, Siv Boon; Thaning, Astrid Josefin; Elschot, Mattijs; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Gierman, Lobke; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)
      Introduction: Inflammation is a normal physiological process that increases to harmful levels in preeclampsia. It affects the interaction between maternal immune cells and fetal trophoblasts at both sites of the maternal-fetal ...

    • Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia 

      Tangerås, Line Haugstad; Austdal, Marie; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)
      Objective—Gestational hypertension and preeclampsia involve dysregulated maternal inflammatory responses to pregnancy, but whether such responses differ between the disorders has not been determined. We aimed to investigate ...

    • Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction 

      Mundal, Siv Boon; Rakner, Johanne Johnsen; Silva, Gabriela; Gierman, Lobke; Austdal, Marie; Basnet, Purusotam; Elschot, Mattijs; Bakke, Siril Skaret; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Moses, Eric; Acharya, Ganesh; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2022)
      Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are ...

    • First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study 

      Austdal, Marie; Tangerås, Line Haugstad; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost (Journal article; Peer reviewed, 2015)
      Hypertensive disorders of pregnancy, including preeclampsia, are major contributors to maternal morbidity. The goal of this study was to evaluate the potential of metabolomics to predict preeclampsia and gestational ...

    • Functional Toll-like receptors in primary first-trimester trophoblasts 

      Tangerås, Line; Stødle, Guro; Olsen, Guro Dalheim; Leknes, Ann-Helen; Gundersen, Astrid; Skei, Bente; Vikdal, Anne Jorunn; Ryan, Liv; Steinkjer, Bjørg; Myklebost, Merete; Langaas, Mette; Austgulen, Rigmor; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2014)
      Toll-like receptors (TLRs) are an important part of the body's danger response system and crucial for initiating inflammation in response to cellular stress, tissue damage, and infections. Proper placental development is ...

    • Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women 

      Steinthorsdottir, Valgerdur; McGinnis, Ralph; Williams, Nicholas O.; Stefánsdóttir, Lilja; Thorleifsson, Gudmar; Shooter, Scott; Fadista, João; Sigurdsson, Jon K.; Auro, Kirsi; Berezina, Galina; Borges, Maria-Carolina; Bumpstead, Suzannah; Bybjerg-Grauholm, Jonas; Colgiu, Irina; Dolby, Vivien A.; Dudbridge, Frank; Engel, Stephanie M.; Franklin, Christopher S.; Frigge, Michael L; Frisbaek, Yr; Geirsson, Reynir T.; Geller, Frank; Gretarsdottir, Solveig; Gudbjartsson, Daniel F.; Harmon, Quaker; Hougaard, David Michael; Hegay, Tatyana; Helgadottir, Anna; Hjartardóttir, Sigrún; Jääskeläinen, Tiina; Johannsdottir, Hrefna; Jonsdottir, Ingileif; Juliusdottir, Thorhildur; Kalsheker, Noor; Kasimov, Abdumadjit; Kemp, John P.; Kivinen, Katja; Klungsøyr, Kari; Lee, Wai K; Melbye, Mads; Miedzybrodska, Zosia; Moffett, Ashley; Najmutdinova, Dilbar; Nishanova, Firuza; Olafsdottir, Thorunn; Perola, Markus; Pipkin, Fiona Broughton; Poston, Lucilla; Prescott, Gordon; Saevarsdottir, Saedis; Salimbayeva, Damilya; Scaife, Paula Juliet; Skotte, Line; Staines-Urias, Eleonora; Stefansson, Olafur A.; Sørensen, Karina Meden; Thomsen, Liv Cecilie Vestrheim; Tragante, Vinicius; Trogstad, Lill; Simpson, Nigel A.B.; Aripova, Tamara; Casas, Juan P; Dominiczak, Anna F; Walker, James J.; Thorsteinsdottir, Unnur; Iversen, Ann-Charlotte; Feenstra, Bjarke; Lawlor, Deborah A.; Boyd, Heather Allison; Magnus, Per; Laivuori, Hannele; Zakhidova, Nodira; Syvatova, Gulnara; Stefansson, Kari; Morgan, Linda (Peer reviewed; Journal article, 2020)
      Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate ...

    • Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene 

      Johnson, Matthew P; Brennecke, Shaun P.; East, Christine; Göring, Harald H H; Kent, Jack W; Dyer, Thomas D.; Said, Joanne M; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Abraham, Lawrence J; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Laivuori, Hannele; Austgulen, Rigmor; Blangero, John; Moses, Eric K (Journal article; Peer reviewed, 2012)
      Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed a genome-wide association study (GWAS) for preeclampsia in unrelated Australian individuals of Caucasian ancestry ...

    • Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors 

      Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Egeland, Grace M.; Nygård, Ottar; Selmer, Randi Marie; Iversen, Ann-Charlotte; Daltveit, Anne Kjersti (Peer reviewed; Journal article, 2019)
      Background and aim Hypertensive pregnancy disorders are associated with subsequent cardiovascular disease (CVD), but the extent to which this association is explained by shared risk factors is unknown. We aimed to evaluate ...

    • Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway 

      Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live; Al-Shibli, Khalid Ibrahim; Andersson, Yvonne; Berg, Thomas; Bjørge, Line; Blix, Egil Støre; Bjerkehagen, Bodil; Brabrand, Sigmund; CAMERON, MARTE; Dalhaug, Astrid; Dietzel, Dalia; Dønnem, Tom; Enerly, Espen; Flobak, Åsmund; Fluge, Sverre; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Grønberg, Bjørn Henning; Grønås, Kari; Guren, Tormod Kyrre; Hamre, Hanne Mari; Haug, Åse; Heinrich, Daniel; Hjortland, Geir Olav; Hovig, Eivind; Hovland, Randi; Iversen, Ann-Charlotte; Janssen, Emiel; Kyte, Jon A; Gythfeldt, Hedda; Lothe, Ragnhild Adelheid; Lund, Jo-Åsmund; Meza, Leonardo Zepeda; Munthe-Kaas, Monica Cheng; Nguyen, Olav Toai Duc; Niehusmann, Pitt; Nilsen, Hilde; Puco, Katarina; Ree, Anne Hansen; Riste, Tonje Bøyum; Semb, Karin; Steinskog, Eli Sihn Samdal; Stensvold, Andreas; Suhrke, Pål; Tennøe, Øyvind Krohn; Tjønnfjord, Geir Erland; Vassbotn, Liv Jorunn; Aas, Eline; Aasebø, Kristine Øverås; Tasken, Kjetil; Smeland, Sigbjørn (Peer reviewed; Journal article, 2022)
      Background Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed ...

    • Incident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and parity 

      Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Nygård, Ottar; Vollset, Stein Emil; Iversen, Ann-Charlotte; Austgulen, Rigmor; Daltveit, Anne Kjersti (Journal article; Peer reviewed, 2017)
      Background Preeclampsia is a severe pregnancy disorder often complicated by reduced fetal growth or preterm delivery and is associated with long‐term maternal morbidity and mortality. We aimed to assess the association ...

    • Inflammation by pattern recognition receptors in the uterine wall decidua and the placenta of normal and preeclamptic pregnancies 

      Silva, Gabriela Brettas (Doctoral theses at NTNU;2020:207, Doctoral thesis, 2020)
      Preeclampsia is a serious inflammatory disorder characterized by hypertension and proteinuria in the second half of pregnancy. It is often associated with severe maternal and fetal complications, such as fetal growth ...

    • Inflammation in Pregnancy – A Study of Pattern Recognition Receptors in Trophoblasts 

      Tangerås, Line Haugstad (Master thesis, 2011)
      Normal pregnancy is characterized by a mildly elevated state of inflammation, as a consequence of the woman’s body adapting to the presence of the growing fetus. The placenta is established in early pregnancy, and constitutes ...