Browsing NTNU Open by Author "Holven, Kirsten Bjørklund"

Now showing items 1-13 of 13

    • Alterations in inflammatory biomarkers and energy intake in cancer cachexia: a prospective study in patients with inoperable pancreatic cancer 

      Bye, Asta; Wesseltoft-Rao, Nima; Iversen, Per Ole; Skjegstad, Grete S; Holven, Kirsten Bjørklund; Ulven, Stine Marie; Hjermstad, Marianne Jensen (Journal article; Peer reviewed, 2016)
      Chronic systemic inflammatory response is proposed as an underlying mechanism for development of cancer cachexia. We conducted a prospective study to examine changes in inflammatory biomarkers during the disease course and ...

    • DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development 

      Quiles-Jiménez, Ana M T; Gregersen, Ida; Segers, Filip; Skarpengland, Tonje; Kroustallaki, Pinelopi; Yang, Kuan; Kong, Xiang Yi; Lauritzen, Knut Husø; Olsen, Maria Belland; Karlsen, Tom Rune; Nyman, Tuula Anneli; Sagen, Ellen Lund; Bjerkeli, Vigdis; Suganthan, Rajikala; Nygård, Ståle; Scheffler, Katja; Prins, Jurriën; Van der Veer, Eric; Øgaard, Jonas; Fløisand, Yngvar; Jørgensen, Helle F.; Holven, Kirsten Bjørklund; Biessen, Erik A.L.; Nilsen, Hilde; Dahl, Tuva Børresdatter; Holm, Sverre; Bennett, Martin R.; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente (Peer reviewed; Journal article, 2021)
      Background and aims Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously ...

    • Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency 

      Macpherson, Magnhild Eide; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Mollnes, Tom Eirik; Berge, Rolf Kristian; Rashidi, Azita; Otterdal, Kari; Gregersen, Ida; Kong, Xiang Yi; Holven, Kirsten Bjørklund; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Journal article; Peer reviewed, 2019)
      Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ...

    • LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases 

      Ronkainen, Justiina; Nedelec, Rozenn; Atehortua, Angelica; Balkhiyarova, Zhanna; Cascarano, Anna; Dang, Vien Ngoc; Elhakeem, Ahmed; Van Enckevort, Esther; Soares, Ana Goncalves; Haakma, Sido; Halonen, Miia; Heilb, Katharina F.; Heiskala, Anni; Hyde, Eleanor; Jacquemin, Bénédicte; Keikkala, Elina; Kerckhoffs, Jules; Klåvus, Anton; Kopinska, Joanna A.; Lepeule, Johanna; Marazzi, Francesca; Motoc, Irina; Näätänen, Mari; Ribbenstedt, Anton; Rundblad, Amanda; Savolainen, Otto; Simonetti, Valentina; De Toro Eadie, Nina; Tzala, Evangelia; Ulrich, Anna; Wright, Thomas; Zarei, Iman; D'Amicov, Enrico; Belotti, Federico; Bruniu, Carl; Castleton, Christopher; Charles, Marie-Aline; Gaillard, Romy; Hanhineva, Kati; Hoek, Gerard; Holven, Kirsten Bjørklund; Jaddoe, Vincent W. V.; Kaakinen, Marika A.; Kajantie, Eero Olavi; Kavousi, Maryam; Lakka, Timo; Matthews, Jason; Mortari, Andrea Piano; Vääräsmäki, Marja; Voortman, Trudy; Webster, Claire; Zinsm, Marie; Atella, Vincenzo; Bulgheroni, Maria; Chadeau-Hyam, Marc; Conti, Gabriella; Evans, Jayne; Felix, Janine F.; Heude, Barbara; Järvelin, Marjo-Riitta; Kolehmaine, Marjukka; Landberg, Rikard; Lekadir, Karim; Parusso, Stefano; Prokopenko, Inga; De Rooij, Susanne R.; Roseboom, Tessa; Swertz, Morris; Timpson, Nicholas; Ulven, Stine Marie; Vermeulen, Roel; Juola, Teija; Sebert, Sylvain (Peer reviewed; Journal article, 2022)
      The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our “modern” postwar societies ...

    • Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia 

      Klevmoen, Marianne; Bogsrud, Martin Prøven; Retterstøl, Kjetil; Svilaas, Tone; Vesterbekkmo, Elisabeth Kleivhaug; Hovland, Anders; Berge, Christ; van Lennep, Jeanine Roeters; Holven, Kirsten Bjørklund (Peer reviewed; Journal article, 2021)
      Background and aims Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when ...

    • Measurements of body fat is associated with markers of inflammation, insulin resistance and lipid levels in both overweight and in lean, healthy subjects 

      Rao, Nima; Holven, Kirsten Bjørklund; Telle, Vibeke Helen; Narverud, Ingunn; Iversen, Per Ole; Hjermstad, Marianne Jensen; Dahlman, Ingrid; Ulven, Stine Marie; Bye, Asta (Journal article; Peer reviewed, 2012)

    • Profiling of immune-related gene expression in children with familial hypercholesterolaemia 

      Narverud, Ingunn; Christensen, Jacob J.; Bakke, Siril Skaret; Ulven, Stine Marie; Rundblad, Amanda; Aukrust, Pål; Espevik, Terje; Bogsrud, Martin Prøven; Retterstøl, Kjetil; Ueland, Thor; Halvorsen, Bente; Holven, Kirsten Bjørklund (Journal article; Peer reviewed, 2019)
      Background Innate and adaptive immune responses are pivotal in atherosclerosis, but their association with early‐stage atherosclerosis in humans is incompletely understood. In this regard, untreated children with familial ...

    • Risk assessment of beta-carotene in food supplements. Scientific opinion of the Panel on Nutrition, Dietetic Products, Novel Food and Allergy 

      Meltzer, Helle Margrete; Holven, Kirsten Bjørklund; Holvik, Kristin; Løvik, Martinus; Frølich, Wenche; Frøyland, Livar; Haugen, Margaretha; Strand, Tor A; Tell, Grethe S.; Iversen, Per Ole (VKM Report;, Research report, 2015)
      Beta-carotene is a provitamin, i.e. a precursor of vitamin A (retinol), which is classified as an essential nutrient for humans. Beta-carotene is one of many carotenoids found in plants, fungi and bacteria. Carotenoids are ...

    • Risk assessment of folic acid in food supplements. Scientific opinion of the Panel on Nutrition, Dietetic Products, Novel Food and Allergy 

      Haugen, Margaretha; Frølich, Wenche; Strand, Tor A; Tell, Grethe S.; Frøyland, Livar; Holven, Kirsten Bjørklund; Holvik, Kristin; Løvik, Martinus; Meltzer, Helle Margrete; Iversen, Per Ole (VKM Report;, Research report, 2015)
      The Norwegian Scientific Committee for Food Safety (VKM) received a request from the Norwegian Food Safety Authority to assess whether the Tolerable Upper Intake Level (UL) of folic acid should be amended in light of new ...

    • Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction 

      Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Holven, Kirsten Bjørklund; Aukrust, Pål; Gullestad, Lars; Yndestad, Arne; Halvorsen, Bente (Journal article; Peer reviewed, 2018)
      Background The IL-6 receptor antagonist tocilizumab has been shown to attenuate the proatherogenic lipoprotein a [Lp(a)] in rheumatoid arthritis. We evaluated if a single dose of tocilizumab reduced Lp(a) in patients with ...

    • Serum Omega-6 Fatty Acids and Immunology-Related Gene Expression in Peripheral Blood Mononuclear Cells: A Cross-Sectional Analysis in Healthy Children 

      Christensen, Jacob J.; Bakke, Siril Skaret; Ulven, Stine Marie; Retterstøl, Kjetil; Henriksen, Tore; Bollerslev, Jens; Espevik, Terje; Aukrust, Pål; Halvorsen, Bente; Holven, Kirsten Bjørklund (Journal article; Peer reviewed, 2019)
      Scope Some studies suggest that a high dietary intake of omega‐6 fatty acids is pro‐inflammatory. However, whether omega‐6 fatty acids actually cause pathogenic inflammation in humans is debated. Therefore, the associations ...

    • The effect of increased protein intake on genome-wide gene expression in peripheral mononuclear cells of home-dwelling old subjects 

      Ulven, Stine Marie; Holven, Kirsten Bjørklund; Rundblad, Amanda; Flatberg, Arnar; Myhrstad, Mari; Karlsen, Karina; Mutt, Shivaprakash; Herzig, Karl-Heinz; Ottestad, Inger; Gjevestad, Gyrd Omholt (Journal article; Peer reviewed, 2019)
      Background Adequate protein intake among older adults is associated with better health outcomes such as immune function and metabolic regulation of skeletal muscle, but conflicting results make it difficult to define the ...

    • The PBMC transcriptome profile after intake of oxidized versus high-quality fish oil: an explorative study in healthy subjects 

      Myhrstad, Mari; Ottestad, Inger; Günther, Clara-Cecilie; Ryeng, Einar; Holden, Marit; Nilsson, Astrid; Brønner, Kirsti Wettre; Kohler, Achim; Borge, Grethe Iren Andersen; Holven, Kirsten Bjørklund; Ulven, Stine Marie (Journal article; Peer reviewed, 2016)
      Background: Marine long-chain polyunsaturated fatty acids are susceptible to oxidation, generating a range of different oxidation products with suggested negative health effects. The aim of the present study was to utilize ...