Blar i NTNU Open på forfatter "Grøntvedt, Gøril Rolfseng"

Viser treff 1-16 av 16

    • Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer's disease, mild cognitive impairment, or healthy controls: a two year follow-up study 

      Sando, Sigrid Botne; Albrektsen, Grethe; Møller, Ina; White, Linda; Berge, Guro; Grøntvedt, Gøril Rolfseng; Lauridsen, Camilla; Bråthen, Geir (Journal article; Peer reviewed, 2016)
      Background α-Synuclein has been proposed as a potential biomarker for Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). However, results from α-synuclein measurements in cerebrospinal fluid (CSF) ...

    • Alzheimer´s disease: Possible biomarkers for prediction and progression 

      Grøntvedt, Gøril Rolfseng (Doctoral theses at NTNU;2022:355, Doctoral thesis, 2022)
      Alzheimers sykdom (AD) er den vanligste årsaken til svikt i kognitive funksjoner og demens og utgjør minst 60 % av alle demenstilfellene. AD er en nevrodegenerativ sykdom som fører til tap av nerveceller. Vi vet at sykdommen ...

    • The Amyloid, Tau, and Neurodegeneration (A/T/N) Classification Applied to a Clinical Research Cohort with Long-Term Follow-Up 

      Grøntvedt, Gøril Rolfseng; Lauridsen, Camilla; Berge, Guro; White, Linda Rosemary; Salvesen, Øyvind; Bråthen, Geir; Sando, Sigrid Botne (Peer reviewed; Journal article, 2020)
      Background: The unbiased amyloid, tau, and neurodegeneration (A/T/N) classification is designed to characterize individuals in the Alzheimer continuum and is currently little explored in clinical cohorts. Objective: A ...

    • Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease 

      Patra, Kalicharan; Soosaipillai, Antoninus; Sando, Sigrid Botne; Lauridsen, Camilla; Berge, Guro; Møller, Ina; Grøntvedt, Gøril Rolfseng; Bråthen, Geir; Begcevic, Ilijana; Moussaud, Simon; Minthon, Lennart; Hansson, Oskar; Diamandis, Eleftherios P.; White, Linda Rosemary; Nielsen, Henrietta M. (Journal article; Peer reviewed, 2018)
      Background Kallikrein 6 (KLK6) is known to be an age-related protease expressed at high levels in the central nervous system. It was previously shown to be involved in proteolysis of extracellular proteins implicated in ...

    • Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden 

      Grøntvedt, Gøril Rolfseng; Sando, Sigrid Botne; Lauridsen, Camilla; Bråthen, Geir; White, Linda Rosemary; Salvesen, Øyvind; Aarsland, Dag; Hessen, Erik; Fladby, Tormod; Waterloo, Knut K; Scheffler, Katja (Journal article; Peer reviewed, 2022)

    • Beyond the Global Brain Differences: Intra-individual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers 

      Bøen, Rune; Kaufmann, Tobias Herbert; van der Meer, Dennis; Frei, Oleksandr; Agartz, Ingrid; Espeseth, Thomas; Håberg, Asta Kristine; Haavik, Jan; Hellard, Stephanie le; Sando, Sigrid Botne; Selbæk, Geir; Grøntvedt, Gøril Rolfseng; Westlye, Lars Tjelta; Selmer, Kaja Kristine; Alnæs, Dag; Andreassen, Ole; Sønderby, Ida Elken (Peer reviewed; Journal article, 2024)
      Background Carriers of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants exhibit regional and global brain differences compared with noncarriers. However, interpreting regional differences is challenging if a ...

    • Cerebrospinal fluid A?43 is reduced in early-onset compared to late-onset Alzheimer's disease, but has similar diagnostic accuracy to A?42 

      Lauridsen, Camilla; Sando, Sigrid Botne; Møller, Ina; Berge, Guro; Pomary, Precious Kwadzo; Grøntvedt, Gøril Rolfseng; Salvesen, Øyvind; Bråthen, Geir; White, Linda (Journal article; Peer reviewed, 2017)
      Background: Amyloid beta 1–43 (Aβ43) may be a useful additional biomarker for diagnosing Alzheimer’s disease (AD). We have investigated cerebrospinal fluid (CSF) levels of Aβ43 in patients with early-onset AD in contrast ...

    • Cerebrospinal Fluid Levels of Amyloid Beta 1-43 in Patients with Amnestic Mild Cognitive Impairment or Early Alzheimer's Disease: A 2-Year Follow-Up Study 

      Lauridsen, Camilla; Sando, Sigrid Botne; Shabnam, Adiba; Møller, Ina; Berge, Guro; Grøntvedt, Gøril Rolfseng; Bakken, Inger Johanne; Salvesen, Øyvind; Bråthen, Geir; White, Linda (Journal article; Peer reviewed, 2016)
      Introduction: Biomarkers that will reliably predict the onset of Alzheimer’s disease (AD) are urgently needed. Although cerebrospinal fluid (CSF) amyloid beta 1–42 (Aβ42), total tau, and phosphorylated tau can be used to ...

    • Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults 

      Hemminghyth, Mathilde Suhr; Chwiszczuk, Luiza; Breitve, Monica Haraldseid; Gisladottir, Berglind; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Rongve, Arvid; Fladby, Tormod; Kirsebom, Bjørn-Eivind Seljelid (Peer reviewed; Journal article, 2023)
      Multiple cognitive domains, including learning, memory, and psychomotor speed, show significant reductions with age. Likewise, several cerebrospinal fluid (CSF) neurodegenerative biomarkers, including total tau (t-tau, a ...

    • CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia 

      Lim, Bryant; Grøntvedt, Gøril Rolfseng; Bathala, Pradeepthi; Kale, Shraddha S.; Campbell, Christopher T.; Stengelin, Martin; Sando, Sigrid Botne; Prassas, Ioannis; Diamandis, Eleftherios P.; Bråthen, Geir (Peer reviewed; Journal article, 2021)
      Neurofilament light (NfL) is a promising biomarker of neurodegeneration in Alzheimer's disease (AD). In this study, cerebrospinal fluid (CSF) NfL was measured in a 24-month longitudinal cohort consisting of control (n = ...

    • Demographically adjusted CERAD wordlist test norms in a Norwegian sample from 40 to 80 years 

      Kirsebom, Bjørn-Eivind; Espenes, Ragna; Hessen, Erik; Waterloo, Knut; Johnsen, Stein Harald; Gundersen, Elisabeth; Sando, Sigrid Botne; Grøntvedt, Gøril Rolfseng; Timón, Santiago; Fladby, Tormod (Journal article; Peer reviewed, 2019)
      Background/Objective: In recent years, several slightly younger cohorts have been established in order to study the preclinical and prodromal phases of dementia. The Consortium to Establish a Registry for Alzheimer’s Disease ...

    • Glial activation and inflammation along the Alzheimer's disease continuum 

      Nordengen, Kaja; Kirsebom, Bjørn-Eivind; Henjum, Kristi; Selnes, Per; Gisladottir, Berglind; Wettergreen, Marianne; Torsetnes, Silje Bøen; Grøntvedt, Gøril Rolfseng; Waterloo, Knut; Aarsland, Dag; Nilsson, Lars; Fladby, Tormod (Journal article; Peer reviewed, 2019)
      Background Neuronal and glial cell interaction is essential for synaptic homeostasis and may be affected in Alzheimer’s disease (AD). We measured cerebrospinal fluid (CSF) neuronal and glia markers along the AD continuum, ...

    • Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease 

      Nordengen, Kaja; Kirsebom, Bjørn-Eivind Seljelid; Richter, Grit; Pålhaugen, Lene; Gisladottir, Berglind; Siafarikas, Nikias Ioannis; Nakling, Arne Exner; Rongve, Arvid; Bråthen, Geir; Grøntvedt, Gøril Rolfseng; Gonzalez, Fernando; Waterloo, Knut; Sharma, Kulbhushan; Karikari, Thomas; Vromen, Eleonora M.; Tijms, Betty M.; Visser, Pieter J.; Selnes, Per; Kramberger, Milicia G.; Winblad, Bengt; Blennow, Kaj; Fladby, Tormod (Peer reviewed; Journal article, 2023)
      Background Brain innate immune activation is associated with Alzheimer’s disease (AD), but degrees of activation may vary between disease stages. Thus, brain innate immune activation must be assessed in longitudinal ...

    • Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort 

      Jarholm, Jonas Alexander; Bjørnerud, Atle; Dalaker, Turi Olene; Akhavi, Mehdi Sadat; Kirsebom, Bjørn-Eivind; Pålhaugen, Lene; Nordengen, Kaja; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Kalheim, Lisa Flem; Almdahl, Ina Selseth; Teceläo, Sandra Raquel Ramos; Fladby, Tormod; Selnes, Per (Peer reviewed; Journal article, 2023)
      Background: Atrophy of the medial temporal lobe (MTL) is a biological characteristic of Alzheimer’s disease (AD) and can be measured by segmentation of magnetic resonance images (MRI). Objective: To assess the clinical ...

    • Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease 

      Giannisis, Andreas; Al-Grety, Asma; Carlsson, Henrik; Patra, Kalicharan; Twohig, Daniel; Sando, Sigrid Botne; Lauridsen, Camilla; Berge, Guro; Grøntvedt, Gøril Rolfseng; Bråthen, Geir; White, Linda Rosemary; Kultima, Kim; Nielsen, Henrietta M. (Peer reviewed; Journal article, 2022)
      Background Low levels of plasma apolipoprotein E (apoE) and presence of the APOE ε4 allele are associated with an increased risk of Alzheimer’s disease (AD). Although the increased risk of AD in APOE ε4-carriers is ...

    • The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease 

      Twohig, Daniel; Rodriguez-Vieitez, Elena; Sando, Sigrid Botne; Berge, Guro; Lauridsen, Camilla; Møller, Ina; Grøntvedt, Gøril Rolfseng; Bråthen, Geir; Patra, Kalicharan; Bu, Guojun; Benzinger, Tammie; Karch, Celeste M.; Fagan, Anne M.; Morris, John C.; Bateman, Randall J.; Nordberg, Agneta; White, Linda Rosemary; Nielsen, Henrietta M. (Journal article; Peer reviewed, 2018)
      Accumulating evidence demonstrating higher cerebrospinal fluid (CSF) α-synuclein (αSyn) levels and αSyn pathology in the brains of Alzheimer’s disease (AD) patients suggests that αSyn is involved in the pathophysiology of ...