Browsing NTNU Open by Author "Fossmark, Reidar"

Adverse effects of proton pump inhibitors – evidence and plausibility

Fossmark, Reidar; Martinsen, Tom Christian; Waldum, Helge (Journal article; Peer reviewed, 2019)

Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there are concerns about overuse and the numerous reported side-effects. It is uncertain whether associations between PPI use and potential ...

Animal models to study the role of long-term hypergastrinemia in gastric carcinogenesis

Fossmark, Reidar; Qvigstad, Gunnar; Martinsen, Tom Christian; Hauso, Øyvind; Waldum, Helge (Journal article; Peer reviewed, 2011)

Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused ...

Behandling av pasienter med ulcerøs colitt som har vært innlagt ved St. Olavs hospital

Wiik, Erik Nesje (Master thesis, 2020)

Introduksjon: Siden innføring av nye og mer effektive medikamenter til behandling av ulcerøs colitt i 2006 har andelen av pasienter som behandles kirurgisk for sykdommen vært synkende. Det er en bekymring blant klinikere ...

Do patients with gastroesophageal reflux disease exhibit compromised bone quality prior to proton pump inhibitor therapy?

Aasarød, Kristin Matre; Mosti, Mats Peder; Finstad, Malin T.; Stunes, Astrid Kamilla; Fossmark, Reidar; Syversen, Unni (Peer reviewed; Journal article, 2021)

Patients with gastroesophageal reflux disease (GERD) are routinely treated with proton pump inhibitors (PPIs), despite many reports of increased fracture risk associated with PPI use. Notably, the skeletal properties in ...

Expression of the Cholecystokinin-B Receptor in Neoplastic Gastric Cells

Mjønes, Patricia; Nordrum, Ivar Skjåk; Sørdal, Øystein Finset; Sagatun, Liv; Fossmark, Reidar; Sandvik, Arne Kristian; Waldum, Helge (Journal article, 2017)

Gastric cancer is an important disease due to its high mortality. Despite the decline in frequency, most cases are discovered late in its course, and most of the cancer patients die within a few years of diagnosis. In ...

Factors associated with the persistence of oral 5-aminosalicylic acid monotherapy in ulcerative colitis: a nationwide Norwegian cohort study

Fossmark, Reidar; Olaisen, Maya; Martinsen, Tom Christian; Melberg, Hans Olav (Journal article; Peer reviewed, 2021)

Background: Oral 5-aminosalicylic acid (5-ASA) is the mainstay treatment of ulcerative colitis (UC) and therapy with oral 5-ASA is associated with beneficial outcomes. We have examined factors associated with the persistence ...

Gastric cancer in Japanese cotton rats

Fossmark, Reidar (Doktoravhandlinger ved NTNU, 1503-8181; 2004:125, Doctoral thesis, 2004)

The role of gastrin and the enterochromaffin-like (ECL) cell in human gastric carcinogenesis is not fully understood. There are numerous animal models that can be useful when studying this process. One such model is the ...

Gastric cancers missed at upper endoscopy in Central Norway 2007 to 2016 - a population-based study

Beck, Marianne; Bringeland, Erling A.; Qvigstad, Gunnar; Fossmark, Reidar (Master thesis, 2021)

Bakgrunn Andelen intervallcancer (IC) ved øvre endoskopi (ØE) har tidligere blitt rapportert å være mellom 4.7% og 9.8% i andre vestlige land. Målet med denne populasjonsbaserte studien var å finne andelen av IC i Midt-Norge ...

Gastric Carcinomas Localized to the Cardia

Bakkelund, Karin Elvenes; Nordrum, Ivar Skjåk; Fossmark, Reidar; Waldum, Helge (Journal article; Peer reviewed, 2012)

Objectives. Gastric adenocarcinomas localized to the cardia are increasing. Enterochromaffin-like (ECL) cells play a role in gastric carcinogenesis in hypergastrinemia, and the use of proton pump inhibitors (PPI) leading ...

Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice

Aasarød, Kristin Matre; Waldum, Helge; Stunes, Astrid Kamilla; Sandvik, Arne Kristian; Flatberg, Arnar; Mjønes, Patricia; Syversen, Unni; Bakke, Ingunn; Fossmark, Reidar (Journal article; Peer reviewed, 2020)

Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric ...

Hepatic micrometastases outside macrometastases are present in all patients with ileal neuroendocrine primary tumour at the time of liver resection.

Fossmark, Reidar; Balto, Tine Marie; Martinsen, Tom Christian; Grønbech, Jon Erik; Munkvold, Bjørn; Mjønes, Patricia; Waldum, Helge (Journal article; Peer reviewed, 2019)

Background: Neuroendocrine tumours (NETs) in the ileum grow slowly but metastasise to the liver at an early stage. After resection of the primary tumour and mesenteric lymph nodes, selected patients with liver metastases ...

Hormones and Neuroendocrine Cells Role in Gastric Tumourigenesis

Sagatun, Liv (Doctoral theses at NTNU;2017:177, Doctoral thesis, 2017)

The localization of the gastrin receptor on the enterochromaffin-like (ECL) cells and the dose-response curve for the histamine releasing effect of gastrin have been shown in rats. Furthermore, in this species the trophic ...

Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study

Ness-Jensen, Eivind; Bringeland, Erling Audun; Mattsson, Fredrik; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2020)

The incidence of proximal gastric adenocarcinoma is increasing among younger adults. Rodent models have shown that hypergastrinemia causes carcinogenesis in the proximal stomach. The aim of our study was therefore to assess ...

Microbiota in inflammatory bowel disease

Olaisen, Maya (Doctoral theses at NTNU;2021:86, Doctoral thesis, 2021)

Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis

Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe; Røyset, Elin Synnøve; Gilde, Bodil; Sandvik, Arne Kristian; Martinsen, Tom Christian; Fossmark, Reidar (Journal article; Peer reviewed, 2019)

Background 5‐aminosalicylic acid (5‐ASA) is the first‐line therapy for ulcerative colitis (UC). 5‐ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N‐acetyltransferase (NAT). ...

Not only stem cells, but also mature cells, particularly neuroendocrine cells, may develop into tumours: time for a paradigm shift

Waldum, Helge; Öberg, Kjell; Sørdal, Øystein Finset; Sandvik, Arne Kristian; Gustafsson, Björn; Mjønes, Patricia; Fossmark, Reidar (Journal article; Peer reviewed, 2018)

Stem cells are considered the origin of neoplasms in general, and malignant tumours in particular, and the stage at which the stem cells stop their differentiation determines the degree of malignancy. However, there is ...