Browsing NTNU Open by Author "Fossmark, Reidar"
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Adverse effects of proton pump inhibitors – evidence and plausibility
Fossmark, Reidar; Martinsen, Tom Christian; Waldum, Helge (Journal article; Peer reviewed, 2019)Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there are concerns about overuse and the numerous reported side-effects. It is uncertain whether associations between PPI use and potential ... -
Animal models to study the role of long-term hypergastrinemia in gastric carcinogenesis
Fossmark, Reidar; Qvigstad, Gunnar; Martinsen, Tom Christian; Hauso, Øyvind; Waldum, Helge (Journal article; Peer reviewed, 2011)Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused ... -
Expression of the Cholecystokinin-B Receptor in Neoplastic Gastric Cells
Mjønes, Patricia; Nordrum, Ivar Skjåk; Sørdal, Øystein Finset; Sagatun, Liv; Fossmark, Reidar; Sandvik, Arne Kristian; Waldum, Helge (Journal article, 2017)Gastric cancer is an important disease due to its high mortality. Despite the decline in frequency, most cases are discovered late in its course, and most of the cancer patients die within a few years of diagnosis. In ... -
Gastric cancer in Japanese cotton rats
Fossmark, Reidar (Doktoravhandlinger ved NTNU, 1503-8181; 2004:125, Doctoral thesis, 2004)The role of gastrin and the enterochromaffin-like (ECL) cell in human gastric carcinogenesis is not fully understood. There are numerous animal models that can be useful when studying this process. One such model is the ... -
Gastric Carcinomas Localized to the Cardia
Bakkelund, Karin Elvenes; Nordrum, Ivar Skjåk; Fossmark, Reidar; Waldum, Helge (Journal article; Peer reviewed, 2012)Objectives. Gastric adenocarcinomas localized to the cardia are increasing. Enterochromaffin-like (ECL) cells play a role in gastric carcinogenesis in hypergastrinemia, and the use of proton pump inhibitors (PPI) leading ... -
Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice
Aasarød, Kristin Matre; Waldum, Helge; Stunes, Astrid Kamilla; Sandvik, Arne Kristian; Flatberg, Arnar; Mjønes, Patricia; Syversen, Unni; Bakke, Ingunn; Fossmark, Reidar (Journal article; Peer reviewed, 2020)Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric ... -
Hepatic micrometastases outside macrometastases are present in all patients with ileal neuroendocrine primary tumour at the time of liver resection.
Fossmark, Reidar; Balto, Tine Marie; Martinsen, Tom Christian; Grønbech, Jon Erik; Munkvold, Bjørn; Mjønes, Patricia; Waldum, Helge (Journal article; Peer reviewed, 2019)Background: Neuroendocrine tumours (NETs) in the ileum grow slowly but metastasise to the liver at an early stage. After resection of the primary tumour and mesenteric lymph nodes, selected patients with liver metastases ... -
Hormones and Neuroendocrine Cells Role in Gastric Tumourigenesis
Sagatun, Liv (Doctoral theses at NTNU;2017:177, Doctoral thesis, 2017)The localization of the gastrin receptor on the enterochromaffin-like (ECL) cells and the dose-response curve for the histamine releasing effect of gastrin have been shown in rats. Furthermore, in this species the trophic ... -
Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mattsson, Fredrik; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2020)The incidence of proximal gastric adenocarcinoma is increasing among younger adults. Rodent models have shown that hypergastrinemia causes carcinogenesis in the proximal stomach. The aim of our study was therefore to assess ... -
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe; Røyset, Elin Synnøve; Gilde, Bodil; Sandvik, Arne Kristian; Martinsen, Tom Christian; Fossmark, Reidar (Journal article; Peer reviewed, 2019)Background 5‐aminosalicylic acid (5‐ASA) is the first‐line therapy for ulcerative colitis (UC). 5‐ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N‐acetyltransferase (NAT). ... -
Not only stem cells, but also mature cells, particularly neuroendocrine cells, may develop into tumours: time for a paradigm shift
Waldum, Helge; Öberg, Kjell; Sørdal, Øystein Finset; Sandvik, Arne Kristian; Gustafsson, Björn; Mjønes, Patricia; Fossmark, Reidar (Journal article; Peer reviewed, 2018)Stem cells are considered the origin of neoplasms in general, and malignant tumours in particular, and the stage at which the stem cells stop their differentiation determines the degree of malignancy. However, there is ... -
Randomized clinical trial of topical tranexamic acid after reduction mammoplasty
Ausen, Kjersti; Fossmark, Reidar; Spigset, Olav; Pleym, Hilde (Journal article; Peer reviewed, 2015)Background The antifibrinolytic drug tranexamic acid is currently being rediscovered for both trauma and major surgery. Intravenous administration reduces the need for blood transfusion and blood loss by about one-third, ... -
Role of Autoimmune Gastritis in Gastric Cancer
Waldum, Helge; Fossmark, Reidar (Journal article; Peer reviewed, 2019)It has been known for 70 years that gastric cancer occurs mainly in a stomach with gastritis. Gastritis was previously so prevalent that it was regarded as an aging phenomenon. Since the description of Helicobacter pylori ... -
Skeletal Effects of Gastric Hypoacidity in Mice and Humans
Aasarød, Kristin Matre (Doctoral theses at NTNU;2016:301, Doctoral thesis, 2016)Effekt av gastrisk hypoaciditet på bein hos mus og mennesker De siste tiårene har flere epidemiologiske studier vist en assosiasjon mellom bruk av syrehemmende medikamenter (protonpumpehemmere (PPI)) og frakturrisiko. ... -
Skeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in rats
Stunes, Astrid Kamilla; Westbroek, Irene; Fossmark, Reidar; Berge, Rolf Kristian; Reseland, Janne Elin; Syversen, Unni (Journal article; Peer reviewed, 2011)This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), ... -
Survival and disease recurrence in patients operated for small intestinal neuroendocrine tumors at a referral hospital.
Folkestad, Oddry H; Wasmuth, Hans; Mjønes, Patricia; Fougner, Reidun; Hauso, Øyvind; Fossmark, Reidar (Peer reviewed; Journal article, 2020)Background and objectives Small intestinal neuroendocrine tumors (SI-NETs) are slow growing but have frequently metastasized at the time of diagnosis. Most patients are operated with either curative intent or with intent ... -
Symptomatic primary (Al) amyloidosis of the stomach and duodenum.
Fossmark, Reidar; Skarsvåg, Espen; Aarset, Harald; Hjort-Hansen, Henrik; Waldum, Helge (Journal article; Peer reviewed, 2013)Primary (AL) amyloidosis of the gastrointestinal tract is relatively rare, and symptomatic amyloidosis of the stomach is even more seldom. We present the case of a patient who was referred to upper endoscopy because of ... -
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival
Vange, Pål; Bruland, Torunn; Doseth, Berit; Fossmark, Reidar; Sousa, Mirta; Beisvag, Vidar; Sørdal, Øystein Finset; Qvigstad, Gunnar; Waldum, Helge; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2017)The cytoprotective protein clusterin is often dysregulated during tumorigenesis, and in the stomach, upregulation of clusterin marks emergence of the oxyntic atrophy (loss of acid-producing parietal cells)-associated ... -
The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats
Stunes, Astrid Kamilla; Westbroek, Irene; Gustafsson, Björn; Fossmark, Reidar; Waarsing, Jan H; Eriksen, Erik Fink; Petzold, Christiane; Reseland, Janne Elin; Syversen, Unni (Journal article; Peer reviewed, 2011)Background Activation of peroxisome proliferator-activated receptor (PPAR)gamma is associated with bone loss and increased fracture risk, while PPARalpha activation seems to have positive skeletal effects. To further ... -
The phylogeny and biological function of gastric juice-microbiological consequences of removing gastric acid
Martinsen, Tom Christian; Fossmark, Reidar; Waldum, Helge (Journal article; Peer reviewed, 2019)Gastric juice is a unique combination of hydrochloric acid (HCl), lipase, and pepsin. Acidic gastric juice is found in all vertebrates, and its main function is to inactivate microorganisms. The phylogenetic preservation ...