Blar i NTNU Open på forfatter "Fossmark, Reidar"
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Hormones and Neuroendocrine Cells Role in Gastric Tumourigenesis
Sagatun, Liv (Doctoral theses at NTNU;2017:177, Doctoral thesis, 2017)The localization of the gastrin receptor on the enterochromaffin-like (ECL) cells and the dose-response curve for the histamine releasing effect of gastrin have been shown in rats. Furthermore, in this species the trophic ... -
Hypergastrinemia and mortality in gastric adenocarcinoma: a population-based cohort study, the HUNT study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2022)Purpose: Hypergastrinemia increases the risk of developing proximal gastric adenocarcinoma. However, it is unclear if hypergastrinemia affects the survival in patients with gastric adenocarcinoma. This study aimed to examine ... -
Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mattsson, Fredrik; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2020)The incidence of proximal gastric adenocarcinoma is increasing among younger adults. Rodent models have shown that hypergastrinemia causes carcinogenesis in the proximal stomach. The aim of our study was therefore to assess ... -
The ileal fungal microbiota is altered in Crohn's disease and is associated with the disease course
Olaisen, Maya; Richard, Mathias L.; Beisvag, Vidar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Rué, Olivier; Martinsen, Tom Christian; Sandvik, Arne Kristian; Sokol, Harry; Fossmark, Reidar (Peer reviewed; Journal article, 2022)Introduction: Fungal microbiota's involvement in the pathogenesis of Crohn's disease (CD) is incompletely understood. The terminal ileum is a predilection site both for primary involvement and recurrences of CD. We, ... -
The impact of proton pump inhibitors on the course of ulcerative colitis: a cohort study of over 10,000 newly diagnosed patients in Norway
Fossmark, Reidar; Lirhus, Sandre Svatun; Høivik, Marte Lie (Peer reviewed; Journal article, 2023)Background and Aims Proton pump inhibitors (PPI) affect the gastrointestinal microbiota, which is thought to play a role in the pathogenesis of ulcerative colitis (UC). Previous studies suggest an association between ... -
Inflammation and Digestive Cancer
Waldum, Helge; Fossmark, Reidar (Journal article; Peer reviewed, 2023)Chronic inflammation is linked to carcinogenesis, particularly in the digestive organs, i.e., the stomach, colon, and liver. The mechanism of this effect has, however, only partly been focused on. In this review, we focus ... -
Is empiric proton pump inhibition in patients with symptoms of extraesophageal gastroesophageal reflux justified?
Fossmark, Reidar; Ness-Jensen, Eivind; Sørdal, Øystein Finset (Peer reviewed; Journal article, 2023)Background The prevalence of gastroesophageal reflux disease (GERD) has had a marked increase in Western countries with a paralleling interest in extraesophageal (EE) manifestations of GERD, including laryngopharyngeal ... -
Microbiota in inflammatory bowel disease
Olaisen, Maya (Doctoral theses at NTNU;2021:86, Doctoral thesis, 2021) -
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe; Røyset, Elin Synnøve; Gilde, Bodil; Sandvik, Arne Kristian; Martinsen, Tom Christian; Fossmark, Reidar (Journal article; Peer reviewed, 2019)Background 5‐aminosalicylic acid (5‐ASA) is the first‐line therapy for ulcerative colitis (UC). 5‐ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N‐acetyltransferase (NAT). ... -
Not only stem cells, but also mature cells, particularly neuroendocrine cells, may develop into tumours: time for a paradigm shift
Waldum, Helge; Öberg, Kjell; Sørdal, Øystein Finset; Sandvik, Arne Kristian; Gustafsson, Björn; Mjønes, Patricia; Fossmark, Reidar (Journal article; Peer reviewed, 2018)Stem cells are considered the origin of neoplasms in general, and malignant tumours in particular, and the stage at which the stem cells stop their differentiation determines the degree of malignancy. However, there is ... -
Randomized clinical trial of topical tranexamic acid after reduction mammoplasty
Ausen, Kjersti; Fossmark, Reidar; Spigset, Olav; Pleym, Hilde (Journal article; Peer reviewed, 2015)Background The antifibrinolytic drug tranexamic acid is currently being rediscovered for both trauma and major surgery. Intravenous administration reduces the need for blood transfusion and blood loss by about one-third, ... -
Role of Autoimmune Gastritis in Gastric Cancer
Waldum, Helge; Fossmark, Reidar (Journal article; Peer reviewed, 2019)It has been known for 70 years that gastric cancer occurs mainly in a stomach with gastritis. Gastritis was previously so prevalent that it was regarded as an aging phenomenon. Since the description of Helicobacter pylori ... -
Skeletal Effects of Gastric Hypoacidity in Mice and Humans
Aasarød, Kristin Matre (Doctoral theses at NTNU;2016:301, Doctoral thesis, 2016)Effekt av gastrisk hypoaciditet på bein hos mus og mennesker De siste tiårene har flere epidemiologiske studier vist en assosiasjon mellom bruk av syrehemmende medikamenter (protonpumpehemmere (PPI)) og frakturrisiko. ... -
Skeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in rats
Stunes, Astrid Kamilla; Westbroek, Irene; Fossmark, Reidar; Berge, Rolf Kristian; Reseland, Janne Elin; Syversen, Unni (Journal article; Peer reviewed, 2011)This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), ... -
Survival and disease recurrence in patients operated for small intestinal neuroendocrine tumors at a referral hospital.
Folkestad, Oddry H; Wasmuth, Hans; Mjønes, Patricia; Fougner, Reidun; Hauso, Øyvind; Fossmark, Reidar (Peer reviewed; Journal article, 2020)Background and objectives Small intestinal neuroendocrine tumors (SI-NETs) are slow growing but have frequently metastasized at the time of diagnosis. Most patients are operated with either curative intent or with intent ... -
Survival and disease recurrence in patients with duodenal neuroendocrine tumours—a single centre cohort
Folkestad, Oddry; Wasmuth, Hans; Mjønes, Patricia; Fougner, Reidun; Hauso, Øyvind; Fossmark, Reidar (Journal article; Peer reviewed, 2021)Background: Duodenal neuroendocrine tumours (D-NETs) are rare but increasingly diagnosed. This study aimed to assess the overall survival and recurrence rate among patients treated for D-NETs. Methods: Patients with D-NETs ... -
Survival Trends in Patients with Small Intestinal Neuroendocrine Tumours—A Cohort Study in Central Norway
Folkestad, Oddry H; Hauso, Øyvind; Mjønes, Patricia Gjertrud; Fougner, Reidun; Wasmuth, Hans; Fossmark, Reidar (Peer reviewed; Journal article, 2023)Improved surgical resection and oncological treatment, or an earlier diagnosis may increase survival in small intestinal neuroendocrine tumours (SI-NETs), but only few studies have examined survival trends. We aimed to ... -
Symptomatic primary (Al) amyloidosis of the stomach and duodenum.
Fossmark, Reidar; Skarsvåg, Espen; Aarset, Harald; Hjort-Hansen, Henrik; Waldum, Helge (Journal article; Peer reviewed, 2013)Primary (AL) amyloidosis of the gastrointestinal tract is relatively rare, and symptomatic amyloidosis of the stomach is even more seldom. We present the case of a patient who was referred to upper endoscopy because of ... -
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival
Vange, Pål; Bruland, Torunn; Doseth, Berit; Fossmark, Reidar; Sousa, Mirta; Beisvag, Vidar; Sørdal, Øystein Finset; Qvigstad, Gunnar; Waldum, Helge; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2017)The cytoprotective protein clusterin is often dysregulated during tumorigenesis, and in the stomach, upregulation of clusterin marks emergence of the oxyntic atrophy (loss of acid-producing parietal cells)-associated ... -
The effect of Roux-en-Y gastric bypass on non-alcoholic fatty liver disease fibrosis assessed by FIB-4 and NFS scores - an 11.6-year follow-up study
Sandvik, Elfrid Christine Smith (Master thesis, 2022)Bakgrunn og formål Overvekt er en sentral risikofaktor for non-alkoholisk fettleversykdom (NAFLD) og fedmekirurgi kan effektivt indusere og vedlikeholde vekttap. Det finnes få langtidsstudier på effekten av Roux-en-Y gastric ...