Blar i NTNU Open på forfatter "Bugge, Steffen"
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Bruk av koblingskjemi i fremstilling av bioaktive tienopyrimidiner
Bugge, Steffen (Master thesis, 2011)Ved bruk av koblingskjemi har tre forskjellige synteseruter blitt utforsket. Disse tre rutene har blitt benyttet til å fremstille ti potensielt biologisk aktive tienopyrimidiner. Hovedvekten av arbeidet har ligget i å ... -
Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit (Journal article; Peer reviewed, 2017)Cell extracts from A549, H460, and U2OS human cancer cell lines treated with cisplatin and docetaxel were analyzed by mass spectrometry (MS) proteomic analysis. The extracts were enriched for cellular signaling proteins ... -
Development of Thienopyrimidines as Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
Bugge, Steffen (Doctoral thesis at NTNU;2015:195, Doctoral thesis, 2015)Abstract: Kinases are very attractive targets in the development of new drugs, due to their many important physiological and pathological functions. In the last few years, there has been a paradigm shift in cancer ... -
Fragment Based Approach in the Search for New Kinase Inhibitors
Moen, Ingri Ullestad (Master thesis, 2014)This master's thesis have been performed in cooperation with a larger researchgroup, as part of an ongoing study. The group is engaged in developing biologicallyactive compounds with potency of inhibiting epidermal growth ... -
Investigation of Heck coupling on 6-bromo[2,3-d]thienopyrimidines for construction of new EGFR inhibitor lead structures
Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Bysting, Fredrik (Journal article; Peer reviewed, 2017)With the aim of identifying new lead structures for EGFR inhibition, a study of palladium catalysed Heck coupling between (R)-6-bromo-N-(1-phenylethyl)thieno[2,3-d]pyrimidin-4-amine and various acrylates was performed. The ... -
Syntese av nye kinase antagonister med potensielt forbedrede medikamentelle egenskaper
Sylte, Kent-Ove Kragseth (Master thesis, 2014)Masteroppgaven er utført som en del av et forskningssamarbeid mellom NTNU og Høgskolen i Sør-Trøndelag, i forskningsgruppen til 1. Amanuensis Bård Helge Hoff og 1. Amanuensis Eirik Sundby. Målet med forskningen er å ... -
Synthesis of Thieno[2,3-d]pyrimidine-Based EGFR-TK Inhibitors with Improved Solubility and Metabolic Stability
Buene, Audun Formo (Master thesis, 2015)The objective of this master s thesis was to synthesize EGFR tyrosine kinase inhibitors with enhanced aqueous solubility, metabolic stability and potency compared with commercially available inhibitors. Improving these ...