Browsing NTNU Open by Author "Bjørnetrø, Tonje"
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An experimental strategy unveiling exosomal microRNAs 486-5p, 181a-5p and 30d-5p from hypoxic tumour cells as circulating indicators of high-risk rectal cancer
Bjørnetrø, Tonje; Redalen, Kathrine; Meltzer, Sebastian; Thusyanthan, Nirujah Sivarajah; Samiappan, Rampradeep; Jegershöld, Caroline; Handeland, Karianne Risberg; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)Tumour hypoxia contributes to poor treatment outcome in locally advanced rectal cancer (LARC) and circulating extracellular vesicles (EVs) as potential biomarkers of tumour hypoxia and adverse prognosis have not been fully ... -
Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer
Meltzer, Sebastian; Bjørnetrø, Tonje; Lyckander, Lars Gustav; Flatmark, Kjersti; Dueland, Svein; Samiappan, Rampradeep; Johansen, Christin; Kalanxhi, Ert; Ree, Anne Hansen; Redalen, Kathrine (Journal article; Peer reviewed, 2019)As many as 30% to 40% of locally advanced rectal cancer (LARC) patients experience metastatic progression of the disease. Recognizing the potential of the genetic cargo in tumor-derived exosomes, we hypothesized that plasma ... -
Corrigendum to “Circulating exosomal miR-141-3p and miR-375 in metastatic progression of rectal cancer” [Transl Oncol 12 (8) (2019) 1038-1044]
Meltzer, Sebastian; Bjørnetrø, Tonje; Lyckander, Lars Gustav; Flatmark, Kjersti; Dueland, Svein; Samiappan, Rampradeep; Johansen, Christin; Kalanxhi, Erta; Ree, Anne Hansen; Redalen, Kathrine (Peer reviewed; Journal article, 2020) -
Next-generation sequencing reveals mitogenome diversity in plasma extracellular vesicles from colorectal cancer patients
Bjørnetrø, Tonje; Bousquet, Paula; Redalen, Kathrine Røe; Siebke, Anne-Marie; Lüders, Torben; Stang, Espen; Sanabria-Moreno, Adriana Maria; Johansen, Christin; Fuglestad, Anniken Jørlo; Kersten, Christian; Meltzer, Sebastian; Ree, Anne Hansen (Peer reviewed; Journal article, 2023)Background Recent reports have demonstrated that the entire mitochondrial genome can be secreted in extracellular vesicles (EVs), but the biological attributes of this cell-free mitochondrial DNA (mtDNA) remain ... -
Protein-protein interactions of the nuclear receprot NR4A2
Bjørnetrø, Tonje (Master thesis, 2014)The Gastroenterology and Molecular cell biology research group examines biological mechanisms that are important in the development of gastric cancer. The peptide hormone gastrin is known to play a role in organization ... -
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund; Fevang, Børre (Journal article; Peer reviewed, 2019)Common variable immunodeficiency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic inflammation and ten “key” bacteria ... -
Uptake of circulating extracellular vesicles from rectal cancer patients and differential responses by human monocyte cultures
Bjørnetrø, Tonje; Steffensen, Lilly Alice; Vestad, Beate; Brusletto, Berit Sletbakk; Olstad, Ole Kristoffer; Siebke, Anne-Marie; Aass, Hans Christian Dalsbotten; Foss, Kari Bente; Llorente, Alicia; Bøe, Stig Ove; Lång, Anna Ulrika; Samiappan, Rampradeep; Redalen, Kathrine; Øvstebø, Reidun; Ree, Anne Hansen (Journal article; Peer reviewed, 2021)Extracellular vesicles (EVs) released by tumor cells can directly or indirectly modulate the phenotype and function of the immune cells of the microenvironment locally or at distant sites. The uptake of circulating EVs and ...