Browsing NTNU Open by Author "Afadzi, Mercy"
Now showing items 1-6 of 6
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Contact-mediated intracellular delivery of hydrophobic drugs from polymeric nanoparticles
Snipstad, Sofie; Westrøm, Sara; Mørch, Ýrr Asbjørg; Afadzi, Mercy; Åslund, Andreas; Davies, Catharina De Lange (Journal article; Peer reviewed, 2014)Encapsulation of drugs in nanoparticles can enhance the accumulation of drugs in tumours, reduce toxicity toward healthy tissue, and improve pharmacokinetics compared to administration of free drug. To achieve efficient ... -
Delivery of Encapsulated Drugs to Cancer Cells and Tissue: The Impact of Ultrasound
Afadzi, Mercy (Doktoravhandlinger ved NTNU, 1503-8181; 2013:57, Doctoral thesis, 2013)Encapsulated drugs have improved tumor to normal tissue uptake compared to free drugs, however, the concentration of drugs at the tumor site is still low and heterogeneous due to the tumor microenvironment which serves as ... -
Detection Of Microcalcifications For Breast Cancer Diagnosis Using SURF Imaging
Afadzi, Mercy (Student paper, others, 2007) -
Effect of Acoustic Radiation Force on the Distribution of Nanoparticles in Solid Tumors.
Afadzi, Mercy; Myhre, Ola Finneng; Yemane, Petros Tesfamichael; Bjørkøy, Astrid; Torp, Sverre Helge; van Wamel, Annemieke; Lelu, Sylvie; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Acoustic radiation force (ARF) might improve the distribution of nanoparticles (NPs) in tumors. To study this, tumors growing subcutaneously in mice were exposed to focused ultrasound (FUS) either 15 min or 4 h after the ... -
Primary Porcine Brain Endothelial Cells as In Vitro Model to Study Effects of Ultrasound and Microbubbles on Blood-Brain Barrier Function
Lelu, Sylvie; Afadzi, Mercy; Berg, Sigrid; Åslund, Andreas; Torp, Sverre Helge; Sattler, Wolfgang; Davies, Ruth Catharina de Lange (Journal article; Peer reviewed, 2017)Focused ultrasound in the presence of microbubbles transiently and reversibly opens the blood-brain barrier (BBB) in rodents and humans thereby providing a time window for increased drug delivery into brain tissue. To get ... -
Ultrasound Stimulated Release of Liposomes
Afadzi, Mercy (Master thesis, 2008)A prerequisite for successful cancer therapy (drug delivery) is that the cytotoxic agents reach all cancer cells and inactivates them and this requires triggerable release of liposomes in order to delivery a high local ...