Browsing NTNU Open by Author "Jacobsen, Elisabeth Egholm"
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A study on the Cytochrome P450 catalyzed production of (S)-perillyl alcohol from (S)-limonene
Næss, Snorre Bergmo (Master thesis, 2020)Abstract will be available on 2023-06-01 -
An Advanced Approach for MgZnAl-LDH Catalysts Synthesis Used in Claisen-Schmidt Condensation
Zăvoianu, Rodica; Mihăilă, Silvana-Denisa; Cojocaru, Bogdan; Tudorache, Mădălina; Pârvulescu, Vasile I.; Pavel, Octavian Dumitru; Economopoulos, Solon; Jacobsen, Elisabeth Egholm (Peer reviewed; Journal article, 2022)Using organic-base tetramethylammonium hydroxide (TMAH) is a viable, cheap, and fast option for the synthesis of MgZnAl-LDH-type materials by both co-precipitation and mechano-chemical methods. TMAH presents several ... -
Biocatalytic resolution of saphenic acid. Substrate preferences for lipases A and B from Candida antarctica
Tjosås, Freddy; Anthonsen, Thorleif; Jacobsen, Elisabeth Egholm (Journal article; Peer reviewed, 2008) -
Biokatalytisk oksidasjon av limonen
Berg, Eirik (Master thesis, 2020)I denne litteraturstudien diskuteres ulike oksidasjoner av limonen katalysert av en rekke biokatalysatorer. Fokuset er spesielt på biotransformasjoner katalysert av cytokrom P450 enzymer, både som rene, isolerte enzymer, ... -
Chemo-enzymatic synthesis of enantiopure penbutolol and penbutolol derivative 1-(tert-butylamino)-3-(4-cyclopentylphenoxy)propan-2-ol
Klungseth, Kristoffer (Master thesis, 2021)I denne oppgaven ble to enantiomert rene stoffer syntetisert ved å bruke Candida antarctica lipase B (CALB) som enantioselektiv biokatalysator i kinetisk resolusjon. (S)-1-(tert-butylamin)-3-(4-syklopentylfenoksy)propan-2-ol ... -
Chemo-Enzymatic Synthesis of Enantiopure β-Antagonist (S)-Betaxolol
Troøyen, Susanne Hansen; Jacobsen, Elisabeth Egholm (Peer reviewed; Journal article, 2022)The β-blocker (S)-betaxolol has been synthesized in 99% enantiomeric excess (ee) from the commercially available precursor 4-(2-hydroxyethyl)phenol. The racemic chlorohydrin 1-chloro-3-(4-(2-(cyclopropylmethoxy)ethyl)phe ... -
Chemoenzymatic Protocol for the Synthesis of Enantiopure β-Blocker (S)-Bisoprolol
Bocquin, Lucas; Jacobsen, Elisabeth Egholm (Peer reviewed; Journal article, 2023)The β-blocker (S)-bisoprolol hemifumarate has been synthesised in 96% enantiomeric excess with 19% total yield in a six-step synthesis. A transesterification reaction of the racemic chlorohydrin 1-chloro-3-(4-((2-isoprop ... -
Chemoenzymatic synthesis of (S)-carteolol: Kinetic resolution by transesterification of precursors with Candida antarctica Lipase B
Rødseth, Mari (Master thesis, 2021)Det har vært et økt fokus på syntese av enantiomert rene aktive farmasøytiske ingredienser de siste tiårene. Kombinert med et økende behov for miljøvennlig kjemi så er det av stor interesse å utforske biokatalytisk syntese ... -
Chemoenzymatic synthesis of enantiopure beta blockers (R)-sotalol, (S)-penbutolol and (S)-bisoprolol
Bocquin, Lucas (Master thesis, 2022)Beta blockers are medications used to reduce blood pressure. In commercial beta blockers, the active pharmaceutical ingredient (API) is always a chiral molecule, and is usually present as a racemic mixture. Usually, one ... -
Chemoenzymatic Synthesis of Synthons as Percursors for Enantiopure Clenbuterol and Other β2-Agonists
Blindheim, Fredrik Heen; Hansen, Mari Bergan; Evjen, Sigvart; Zhu, Wei; Jacobsen, Elisabeth Egholm (Journal article; Peer reviewed, 2018)Clenbuterol is a β2-agonist used in the veterinary treatment of asthma in several countries. The drug is listed on the World Antidoping Agency’s prohibited list due to its effect on increased protein synthesis in the body. ... -
Development of an inventory for Alternative Conceptions among students in chemistry
Eggen, Per-Odd; Persson, Rolf Jonas; Jacobsen, Elisabeth Egholm; Hafskjold, Bjørn (Journal article; Peer reviewed, 2017)A Chemistry concept inventory has been developed for assessing students learning and identifying the alternative conceptions that students may have in general chemistry. The conceptions in question are assumed to be mainly ... -
Effekten av inhalert linalool som angstreduserende middel sammenlignet med andre innføringsmetoder og SSRI medikamenter
Røv, Selma (Bachelor thesis, 2022)I denne oppgaven har jeg sammenlignet ulike studier for å finne effekten av inhalert linalool som angstreduserende stoff i forhold til andre serotoninregulerende stoffer og innføringsmetoder. Linalool, et av de aktive ... -
Green Chemo-Enzymatic Protocols for the Synthesis of Enantiopure β-Blockers (S)-Esmolol and (S)-Penbutolol
Troøyen, Susanne Hansen; Bocquin, Lucas; Tennfjord, Anna Lifen; Klungseth, Kristoffer; Jacobsen, Elisabeth Egholm (Journal article; Peer reviewed, 2022) -
Green synthesis of silver nanoparticles for medicinal purposes
Rodrigues, Madalena (Bachelor thesis, 2023)Sølv nanopartikler (AgNP), blant andre nanopartikler, er kjent på grunn av deres unike egenskaper. For å bidra til studiet av medisin og behandling av sykdommer som kreft, syntetiseres de, vanligvis ved hjelp av ekstrakter ... -
Highly enantioselective CALB-catalyzed kinetic resolution ofbuilding blocks for β-blocker atenolol
Lund, Ingvild; Bøckmann, Pål Lønnegraff; Jacobsen, Elisabeth Egholm (Journal article, 2016)Both enantiomers of 4-(3-chloro-2-hydroxypropoxy)phenyl)acetamide has been synthesized in 98.5–99% enantiomeric excess by use of lipase B from Candida antarctica as catalyst. The R-alcohol is a building block for the ... -
Hvordan fungerer det anerkjente smertelindrende stoffet ketamin i behandling mot depresjon, og er ketamin et trygt stoff å bruke?
Kvamme, Maria Fink (Bachelor thesis, 2020)Ketamin, solgt i Norge under handelsnavnet Ketalar®, er i hovedsak et legemiddel brukt mot smertelindring. I 2020 ble ketamin godkjent som legemiddel mot depresjon, da det ble konstatert at legemiddelet i små doser ga ... -
Hvorfor er noen narkotiske stoffer bedre enn andre?
Horn, Cornelia (Bachelor thesis, 2021)I verden finnes det en mengde ulike narkotiske stoffer, slik som for eksempel cannabis, amfetaminer, opiater og kokain. Våren 2021 var en rusreform oppe til behandling i Stortinget, men denne ble nedstemt. Innholdet i denne ... -
Immobilization does not influence the enantioselectivity of CAL-B catalyzed kinetic resolution of secondary alcohols
Jacobsen, Elisabeth Egholm; Andresen, Liv Siri; Anthonsen, Thorleif (Journal article; Peer reviewed, 2005)Decreasing enantioselectivity (E-value) by conversion has been observed in transesterification reactions of secondary alcohols catalyzed by a pure protein formulation of lipase B from Candida antarctica (Novozym 525 F). ... -
Improved understanding of reagents used in the syntheses of enantiopure precursors for (S)-atenolol and (S)-metoprolol
Hansen, Mari Bergan (Master thesis, 2019)Målet med denne masteroppgaven var å undersøke effektene av de ulike reagensene brukt i syntesen av enantiomert rene forløpere, som et bidrag til økt miljøvennlighet i totalsyntesene av (S)-atenolol og (S)-metoprolol. Syntesen ...