Blar i NTNU Open på forfatter "Jacobsen, Elisabeth Egholm"
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Investigating learners' viewing behaviour in watching a designed instructional video
Persson, Rolf Jonas; Wattengård, Eirik; Jacobsen, Elisabeth Egholm (Journal article; Peer reviewed, 2017)The production and use of video in education has increased during recent years. However, most videos are not properly designed to enhance attention and learning. In this article, we report on the design of an instructional ... -
Kjemo-enzymatisk syntese av enantiomert rene halogenerte syklopropaner og triflatestere
Eliassen, Sigve (Master thesis, 2014)Med utgangspunkt i en rasemisk blanding av 1-(2.2-dibrom-1-1metylsyklopropyl)etanol har enantiomert rent dihalobisyklobutanol blitt forsøkt syntetisert og karakterisert. Først ble en rasemisk blanding av (1R,1'R)-1a og ... -
Likheter og forskjeller i virkning og bivirkning hos virkestoffene alemtuzumab og interferon ß-1a i behandling av attakkvis multippel sklerose
Fiske, Ingrid Kvendset (Bachelor thesis, 2020)Multippel sklerose er en alvorlig, inflammatorisk sykdom hvor pasienten får nedsatt nevrologisk funksjonalitet og levetiden blir ofte drastisk forkortet. Det eksisterer ingen medisinsk behandling som kurerer multippel ... -
Lipase Catalysed Kinetic Resolution of Stiripentol
Jacobsen, Elisabeth Egholm; Anthonsen, Thorleif; El-Behairy, Mohammed Farrag; Sundby, Eirik; Aboul-Enein, Mohamed Nabil; Attia, Mohamed Ibrahim; El-Azzouny, Aida Abd El-Sattar; Amin, Kamilia M.; Abdel-Rehim, Mohamed (Journal article; Peer reviewed, 2012)Kinetic resolution of rac-Stiripentol, catalysed by lipase A from Candida antarctica by esterification with vinyl butanoate was performed with an E-value of 24. This allowed isolation of (3S)-Stiripentol with an ee of 86 ... -
Lipase Catalyzed Synthesis of Enantiopure Precursors and Derivatives for β-Blockers Practolol, Pindolol and Carteolol
Gundersen, Morten Andre; Austli, Guro Buaas; Løvland, Sigrid Sløgedal; Hansen, Mari Bergan; Rødseth, Mari; Jacobsen, Elisabeth Egholm (Peer reviewed; Journal article, 2021)Sustainable methods for producing enantiopure drugs have been developed. Chlorohydrins as building blocks for several β-blockers have been synthesized in high enantiomeric purity by chemo-enzymatic methods. The yield of ... -
Mekanistiske studier i kjemo-enzymatisk syntese av enantiomert rene byggestener for betablokkeren Atenolol
Lund, Ingvild Teigen (Master thesis, 2015)Byggestener for atenolol er blitt syntetisert. Det er blitt utført kinetisk oppløsning på byggestenene med CALB for å få enantiomert rene produkter. CALB var meget enantioselektiv i de kinetiske oppløsningene. Det ble ... -
Semisyntese av paclitaxel - et historisk perspektiv
Engås, Kristoffer Tennfjord (Bachelor thesis, 2023)Det viktige kreftbehandlingsstoffet paclitaxel, som kommer fra barken på stillehavsbarlinden, er ikke bærekraftig å ekstrahere fra den saktevoksende planten. Blant andre alternativer for anskaffelse er semisyntese av ... -
Single Enantiomers from Racemates. Lipase catalysed Kinetic Resolution of Secondary Alcohols. In situ Stereoinversion
Jacobsen, Elisabeth Egholm; Anthonsen, Thorleif (Journal article; Peer reviewed, 2017)Kinetic resolution catalysed by lipases is a well suited strategy in order to provide enantiopure organic compounds. Factors affecting the enantiomeric ratio, the E-value, such as substrate structure, temperature effects, ... -
Steps towards chemo-enzymatic synthesis of enantiomerically pure Levosalbutamol
Tveit, Erik Våland (Master thesis, 2015)Asthma is one of the most common non-communicable diseases in the world, affecting almost 4 % of the world's population. The cause behind asthma is not understood, but it is believed to be a combination of genetic ... -
Stiripentol as Treatment for Epileptic Seizures
Howlid, Charlotte (Bachelor thesis, 2024)I denne oppgaven skal stiripentols mekanismer mot epilepsi diskuteres. Stiripentol er et legemiddel mest brukt mot Dravet syndrom, en sjelden barneepilepsi med høy dødsrate. Mekanismene mot epilepsi består av enzyminhibering, ... -
Synthesis of (S)-pindolol with Lipase B from Candida antarctica as catalyst
Dale, Oskar (Master thesis, 2019)Målet med denne oppgaven er å syntetisere enantioren (R)-1-((1H-indol-4-yl)oxy)-3-chloropropan-2-ol ((R)-2) og å syntetisere (S)-pindolol ((S)-5) fra (R)-2. En kjemoenzymatisk syntese av β-blokkeren (S)-pindolol ((S)-5) ... -
Synthesis of 4-(2-(cyclopropylmethoxy)ethyl)phenol, a precursor for S-betaxolol
Trohjell, Raymond (Master thesis, 2021)Enantiomert rene legemidler blir dannet mer og mer fremfor rasemiske legemidler. (S)-betaksolol (S-1) er en β-blokker som har vist stort potensiale i behandling av glaukom. Det er blitt vist at (S)-enantiomeren av betaksolol ... -
Synthesis of building blocks for (S)-pindolol and vitamin K2 by use of lipase catalysis
Løvland, Sigrid Sløgedal (Master thesis, 2018)The objective of this thesis has been to synthesize an enantiopure building block of beta-blocker (S)-pindolol. This has been attempted by organic synthesis followed by lipase catalysis using candida antarctica lipase B ... -
Synthesis of enantiopure building blocks for biologically active compounds by enzyme catalysis. Optimizing reaction conditions for increased enantioselectivity and activity
Jacobsen, Elisabeth Egholm (Doktoravhandlinger ved NTNU, 1503-8181; 2004:50, Doctoral thesis, 2004)Efficient methods for synthesis of enantiomerically pure enantiomers of a series of secondary alcohols and butanoates have been performed by kinetic resolution of the racemic alcohols and esters catalyzed by lipase B from ... -
Synthesis of Enantiopure Derivative of β-Blocker (S)-carteolol by Lipase Catalysis
Gundersen, Morten André (Master thesis, 2020)Abstract will be available on 2023-06-01 -
Synthesis of Enantiopure Precursors for Clenbuterol
Blindheim, Fredrik Heen (Master thesis, 2017)The primary goal of this thesis was to synthesize enantiopure (R)-clenbuterol and its precursors by using enzymes as chiral catalysts. As a secondary goal, the substrate acceptance of ketoreductase 228 (KRED 228) was ... -
Synthesis of enantiopure ß-blocker (S)-esmolol
Tennfjord, Anna Lifen (Master thesis, 2021)β-Blokkere er β-adrenerge antagonister som blokkerer den naturlige cellulære responsen til adrenalin i β-reseptorer. β-Blokkere er medisiner som kan bli brukt i behandling av vanlige sykdommer som hypertensjon og angina ... -
Synthesis of enantiopure β-blocker (S)-metoprolol and derivatives by lipase catalysis
Bøckmann, Pål Lønnegraff (Master thesis, 2016)The goal of this thesis was to synthesize the enantiomerically pure β-blocker (S)-metoprolol through the use of biocatalysis and elucidate potential factors that may influence the selectivity of enzymes. The model substrate ... -
Synthesis of Enantiopure β-Blocker (S)-Practolol by Lipase Catalysis
Austli, Guro Buaas (Master thesis, 2018)Finding a more environmentally friendly method for synthesis of enantiopure drugs is important, due to the principles of green chemistry and to avoid potential side effects from racemic drugs. The aim for this thesis was ... -
Use of Photocatalytically Active Supramolecular Organic–Inorganic Magnetic Composites as Efficient Route to Remove β-Lactam Antibiotics from Water
Ion, Sabina G.; Pavel, Octavian D.; Guzo, Nicolae; Tudorache, Madalina; Coman, Simona M.; Parvulescu, Vasile I.; Cojocaru, Bogdan; Jacobsen, Elisabeth Egholm (Peer reviewed; Journal article, 2022)Considerable efforts have been made in recent years to identify an optimal treatment method for the removal of antibiotics from wastewaters. A series of supramolecular organic-inorganic magnetic composites containing ...