Blar i NTNU Open på forfatter "Sætrom, Pål"

Viser treff 41-60 av 84

    • Investigation of properties and classification of human transcription factors 

      Bahrami, Shahram (Doctoral theses at NTNU;2016:243, Doctoral thesis, 2016)
      Studier av egenskaper og klassifisering av humane transkripsjonsfaktorer Egenskaper og funksjonen av ulike celler bestemmes gjennom regulering av genuttrykket, og en rekke ulike mekanismer er aktive i den enkelte ...

    • Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation 

      Hegre, Siv Anita; Samdal, Helle; Klima, Antonin; Stovner, Endre Bakken; Nørsett, Kristin Gabestad; Liabakk, Nina-Beate; Olsen, Lene Christin; Chawla, Konika; Aas, Per Arne; Sætrom, Pål (Peer reviewed; Journal article, 2021)
      Proper regulation of the cell cycle is necessary for normal growth and development of all organisms. Conversely, altered cell cycle regulation often underlies proliferative diseases such as cancer. Long non-coding RNAs ...

    • Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile 

      Huang, Kai-Wen; Reebye, Vikash; Czysz, Katherine; Ciriello, Simona; Dorman, Stephanie; Reccia, Isabella; Lai, Hong-Shiee; Peng, Ling; Kostomitsopoulos, Nikos; Nicholls, Joanna; Habib, Robert; Tomalia, Donald A.; Sætrom, Pål; Wilkes, Edmund; Cutillas, Pedro; Rossi, John; Habib, Nagy (Peer reviewed; Journal article, 2020)
      Non-alcoholic fatty liver disease (NAFLD) culminates in insulin resistance and metabolic syndrome. Because there are no approved pharmacological treatment agents for non-alcoholic steatohepatitis (NASH) and NAFLD, different ...

    • Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation 

      Rolinski, Milosz; Montaldo, Nicola Pietro; Aksu, Merdane Ezgi; Martin, Sarah Fordyce; Brambilla, Alessandro; Kunath, Nicolas; Johansen, Jostein; Erlandsen, Sten Even; Liabakk, Nina-Beate; Rian, Kristin; Bjørås, Magnar; Sætrom, Pål; van Loon, Barbara (Peer reviewed; Journal article, 2020)
      Alkylating drugs are among the most often used chemotherapeutics. While cancer cells frequently develop resistance to alkylation treatments, detailed understanding of mechanisms that lead to the resistance is limited. Here, ...

    • Major gene expression changes and epigenetic remodelling in Nile tilapia muscle after just one generation of domestication 

      Konstantinidis, Ioannis; Sætrom, Pål; Mjelle, Robin; Nedoluzhko, Artem; Robledo, Diego; Fernandes, Jorge Manuel de Oliveira (Peer reviewed; Journal article, 2020)
      The historically recent domestication of fishes has been essential to meet the protein demands ofa growing human population. Selection for traits of interest during domestication is a complexprocess whose epigenetic basis ...

    • Mapping next generation sequence data - existing methods and a new non-coding RNA pipeline 

      Steiro, Espen (Master thesis, 2011)
      This paper touches on several different aspects in the field of bioinformatics.Some of the challenges facing the bioinformatics community will be discussedalong with why these challenges still need a lot of research. How ...

    • Meta-analysis of breast cancer microarray studies in conjunction with conserved cis-elements suggest patterns for coordinate regulation 

      Smith, DD; Sætrom, Pål; Snøve, Ola; Lundberg, C; Rivas, GE; Glackin, C; Larson, GP (Journal article; Peer reviewed, 2008)
      Background: Gene expression measurements from breast cancer (BrCa) tumors are established clinical predictive tools to identify tumor subtypes, identify patients showing poor/good prognosis, and identify patients likely ...

    • MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity 

      Solvin, Åshild Øksnevad; Chawla, Konika; Olsen, Lene Christin; Hegre, Siv Anita; Danielsen, Kjersti; Jenssen, Marita; Furberg, Anne-Sofie; Saunes, Marit; Hveem, Kristian; Sætrom, Pål; Løset, Mari (Peer reviewed; Journal article, 2021)
      MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as central regulators of gene expression and powerful biomarkers of disease. Much is yet unknown about their role in psoriasis pathology. To globally characterize ...

    • MicroRNA-181a* Targets Nanog in a Subpopulation of CD34+ Cells Isolated From Peripheral Blood 

      Mintz, Paul J; Sætrom, Pål; Reebye, Vikash; Lundbæk, Marie Benner; Lao, Kaiqin; Rossi, John J; Gaensler, Karin ML; Kasahara, Noriyuki; Nicholls, Joanna P; Jensen, Steen; Haoudi, Abdelali; Emara, Mohamed M; Gordon, Myrtle YA; Habib, Nagy A (Journal article; Peer reviewed, 2012)
      Exploiting the properties of stem cells by microRNA (miRNA) profiling offers an attractive approach to identify new regulators of stem cell fate. Although numerous miRNA have been screened from hematopoietic stem cells ...

    • MicroRNAs and Transcriptional Control 

      Skaland, Even (Master thesis, 2009)
      Background: MicroRNAs are small non-coding transcripts that have regulatory roles in the genome. Cis natural antisense transcripts are transcripts overlapping a sense transcript at the same loci in the genome, but at the ...

    • MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex 

      Olsen, Lene Christin; O'Reilly, Kally; Liabakk, Nina-Beate; Witter, Menno; Sætrom, Pål (Journal article; Peer reviewed, 2017)
      The medial entorhinal cortex (MEC) is important in spatial navigation and memory formation and its layers have distinct neuronal subtypes, connectivity, spatial properties, and disease susceptibility. As little is known ...

    • miRNA and mRNA expression in the hippocampal region during postnatal developments in rats 

      Olsen, Lene Christin (Doctoral theses at NTNU;2018:66, Doctoral thesis, 2018)
      Hjernestrukturene entorhinal cortex og hippocampus er viktige for minnefunksjon og navigering. Innenfor hver av disse strukturene finnes underregioner som har forskjellige celletyper og forbindelser i hjernen. Noen av ...

    • Mitodetect: Estimering av felles stammor i HUNT undersøkelsen 

      Gudem, Alice (Master thesis, 2019)
      Mitokondrie-DNA blir arvet fra mor til barn, i motsetning til vanlig, autosomt DNA som blir arvet fra begge foreldre. Dette betyr at personer som er fjernt i slekt vil ha veldig lite vanlig DNA til felles, men de kan ha ...

    • Modelling Cell Cycle Phase Distribution in Cell Cultures 

      (Master thesis, 2019)
      Vi benytter oss av enkeltcelle RNA genekspresjonsdata for å studere cellesyklusen. To metoder for enkeltcelle RNA genekspresjonskvantifisering sammenlignes. Vi analyserer både tellematrisene og ytelsen på begge metodene. ...

    • Modelling microRNA regulation in time series data 

      Tomasdottir, Tinna (Master thesis, 2014)
      MicroRNA (mRNA) is a gene regulating factor that binds to messenger RNA (mRNA) and inhibits translation or causes degradation of the mRNA. Many methods are available to predict which mRNAs are targets for miRNA but most ...

    • Motif kernel generated by genetic programming improves remote homology and fold detection 

      Håndstad, Tony; Hestnes, Arne Johan Husebø; Sætrom, Pål (Journal article; Peer reviewed, 2007)
      Background: Protein remote homology detection is a central problem in computational biology. Most recent methods train support vector machines to discriminate between related and unrelated sequences and these studies ...

    • NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice 

      Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar; Bugaj, Anna Maria; Fernandez Berrocal, Marion Silvana; SIkko, Sunniva Bøe; Vetlesen, Susanne; Kusnierczyk, Anna; Olsen, Ann-Karin Hardie; Gutzkow, Kristine Bjerve; Rowe, Alexander D.; Wang, Wei; Moldestad, Olve; Syrstad, Monika; Slupphaug, Geir; Eide, Lars; Klungland, Arne; Sætrom, Pål; Luna, Luisa; Ye, Jing; Scheffler, Katja; Bjørås, Magnar (Peer reviewed; Journal article, 2021)
      Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 ...

    • NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture 

      Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar; Finsen, Alexandra (Journal article; Peer reviewed, 2017)
      Myocardial infarction (MI) triggers a reparative response involving fibroblast proliferation and differentiation driving extracellular matrix modulation necessary to form a stabilizing scar. Recently, it was shown that a ...

    • Non-coding RNAs in human breast milk: A systematic review 

      Tingö, Lina; Ahlberg, Emelie; Johansson, Lovisa; Pedersen, Sindre Andre; Chawla, Konika; Sætrom, Pål; Cione, Erika; Simpson, Melanie Rae (Peer reviewed; Journal article, 2021)
      Breast milk is the primary source of nutrition and hydration for the newborn infant but also plays an important role in the child’s first immune defense. Additionally, several breast milk factors have been implicated in ...

    • ontoWiz: Making Tasks of Reasoning Fast 

      Ekseth, Ole Kristian (Master thesis, 2013)
      Oppgaven består i å lage et verktøy for søk i biomedisinske ontologier.