Blar i NTNU Open på forfatter "Sætrom, Pål"
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Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway
Robles, Ana I.; Olsen, Karina Standahl; Tsui, Dana W.T.; Georgoulias, Vassilis; Creaney, Jenette; Dobra, Katalin; Vyberg, Mogens; Minato, Nagahiro; Anders, Robert A.; Børresen-Dale, Anne-Lise; Zhou, Jianwei; Sætrom, Pål; Nielsen, Boye Schnack; Kirschner, Michaela B.; Krokan, Hans Einar; Papadimitrakopoulou, Vassiliki; Tsamardinos, Ioannis; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2016)The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The “1st International NTNU Symposium ... -
Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks
Skogholt, Anne Heidi; Ryeng, Einar; Erlandsen, Sten Even; Skorpen, Frank; Arentz Schønberg, Svanhild Margrethe; Sætrom, Pål (Journal article; Peer reviewed, 2017)Background Gene expression profiling from blood is sensitive to technology choices. For example, the main blood RNA collection systems—the PAXgene and Tempus tubes—differently influence RNA expression signatures. The aim ... -
Gene expression in blood reflects smoking exposure among cancer-free women in the Norwegian Women and Cancer (NOWAC) postgenome cohort
Baiju, Nikita; Sandanger, Torkjel M; Sætrom, Pål; Nøst, Therese Haugdahl (Journal article; Peer reviewed, 2021)Active smoking has been linked to modulated gene expression in blood. However, there is a need for a more thorough understanding of how quantitative measures of smoking exposure relate to differentially expressed genes ... -
Gene expression profile changes after short-activating RNA-mediated induction of endogenous pluripotency factors in human mesenchymal stem cells
Voutila, J; Sætrom, Pål; Mintz, Paul J; Sun, Guihua; Alluin, Jessica; Rossi, JJ; Habib, Nagy A.; Kasahara, N. (Journal article; Peer reviewed, 2012)It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells. Using bioinformatics analysis and functional screening, we screened ... -
Genome-wide hydroxymethylation profiles in liver of female Nile tilapia with distinct growth performance
Konstantinidis, Ioannis; Sætrom, Pål; Fernandes, Jorge Manuel de Oliveira (Peer reviewed; Journal article, 2023)The mechanisms underlying the fast genome evolution that occurs during animal domestication are poorly understood. Here, we present a genome-wide epigenetic dataset that quantifies DNA hydroxymethylation at single nucleotide ... -
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
Landfors, Miriam; Johansen, Jostein; Aronsen, Jan Magnus; Vågbø, Cathrine Broberg; Doré, Louis C.; He, Chuan; Sjaastad, Ivar; Sætrom, Pål; Fedorcsák, Péter; Dahl, John Arne; Aanes, Håvard; Fusser, Markus; Klungland, Arne (Journal article; Peer reviewed, 2017)Sertoli cells have dual roles during the cells’ lifetime. In the juvenile mammal, Sertoli cells proliferate and create the structure of the testis, and during puberty they cease to proliferate and take on the adult role ... -
Genomic alterations in psoriasis and implications for disease burden
Solvin, Åshild Øksnevad (Doctoral theses at NTNU;2024:142, Doctoral thesis, 2024)Introduction: Psoriasis is a common chronic inflammatory skin disease with a substantial genetic etiological component. It is associated with diverse comorbidities, increasing the disease burden. Estimated global prevalence ... -
Hardware accelerated genetic programming for pattern mining in strings
Sætrom, Pål (Doktoravhandlinger ved NTNU, 1503-8181; 2005:197, Doctoral thesis, 2005)This thesis considers the problem of mining patterns in strings. Informally, this is the problem of extracting information (patterns) that characterizes parts of, or even the complete, string. The thesis describes a high ... -
Hardware accelerated sequence analysis
Hestnes, Arne Johan (Master thesis, 2005)The thesis evaluates two different techniques for using hardware acceleration in sequence analysis. The problem at hand is to detect remote homologies in protein sequences. This is useful for medical purposes, since protein ... -
Human Breast Milk miRNA, Maternal Probiotic Supplementation and Atopic Dermatitis in Offspring
Simpson, Melanie Rae; Brede, Gaute; Johansen, Jostein; Johnsen, Roar; Storrø, Ola; Sætrom, Pål; Øien, Torbjørn (Peer reviewed; Journal article, 2015)Background: Perinatal probiotic ingestion has been shown to prevent atopic dermatitis (AD) in infancy in a number of randomised trials. The Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT) trial ... -
Identification and characterization of long noncoding RNAs involved in the cell cycle
Samdal, Helle (Doctoral theses at NTNU;2021:234, Doctoral thesis, 2021)Lange ikke-kodende RNA involvert i cellesyklus For å produsere nye celler må kroppens celler dele seg til to identiske kopier i en prosess som kalles cellesyklus. Dette er en nøye kontrollert prosess for å sikre at ... -
Identification of metastasis-associated microRNAs in serum from rectal cancer patients
Mjelle, Robin; Sellæg, Kjersti; Sætrom, Pål; Thommesen, Liv; Sjursen, Wenche; Hofsli, Eva (Peer reviewed; Journal article, 2017)MicroRNAs (miRNAs) are promising prognostic and diagnostic biomarkers due to their high stability in blood. Here we investigate the expression of miRNAs and other noncoding (nc) RNAs in serum of rectal cancer patients. ... -
Identifying a cross-cohort circulating microRNA signature for Lung Cancer prediction using Random Forests
Fauchald, Erlend (Master thesis, 2021)Lungekreft er en sykdom hvor tidlig diagnose er spesielt viktig for pasientoverlevelse. Screeningteknikker som brukes i dag fokuserer ofte på pasienter i risikogrupper fordi de er invasive, kostbare og har lav spesifisitet. ... -
Identifying miRNA short reads as potential markers for biologically active miRNAs
Wahl, Kristin (Master thesis, 2015)MicroRNAs (miRNAs) are a group of ~22 nt non-coding RNAs that since their discovery in 2001 have been extensively studied, and their post-transcriptional gene-regulatory role in animals and plants have been linked to a ... -
Identifying robust blood-based messenger RNA (mRNA) markers for potential detection of lung cancer: The Lung Cancer Biobank (NLCB) and the Nord-Trøndelag Health Study (HUNT) and Norwegian Women and Cancer Cohort (NOWAC)
Skogholt, Anne Heidi (Doctoral theses at NTNU;2021:310, Doctoral thesis, 2021) -
In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol
Larose, Tricia L; Sætrom, Pål; Martinussen, Marit; Skogseth, Haakon; Sandanger, Torkjel M; Scélo, Ghislaine; McHale, Cliona M; Jacobsen, Geir Wenberg; Smith, Martyn T (Journal article; Peer reviewed, 2019)Background: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be ... -
Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis
Urbarova, Ilona Halva; Skogholt, Anne Heidi; Sun, Yi-Qian; Mai, Xiao-Mei; Grønberg, Bjørn Henning; Sandanger, Torkjel Manning; Sætrom, Pål; Nøst, Therese Haugdahl (Peer reviewed; Journal article, 2023)Lung cancer (LC) mortality rates are still increasing globally. As survival is linked to stage, there is a need to identify markers for earlier LC diagnosis and individualized treatment. The whole blood transcriptome of ... -
Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer
Nøst, Therese Haugdahl; Skogholt, Anne Heidi; Urbarova, Ilona Halva; Mjelle, Robin; Paulsen, Erna-Elise; Dønnem, Tom; Andersen, Sigve; Markaki, Maria; Røe, Oluf Dimitri; Johansson, Mikael; Johansson, Mattias; Grønberg, Bjørn Henning; Sandanger, Torkjel M; Sætrom, Pål (Peer reviewed; Journal article, 2022)Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood ... -
Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer
Nøst, Therese Haugdahl; Skogholt, Anne Heidi; Urbarova, Ilona Halva; Mjelle, Robin; Paulsen, Erna-Elise; Dønnem, Tom; Andersen, Sigve; Markaki, Maria; Røe, Oluf Dimitri; Johansson, Mikael; Johansson, Mattias; Grønberg, Bjørn Henning; Sandanger, Torkjel M; Sætrom, Pål (Peer reviewed; Journal article, 2022)Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood ... -
Inferring causative variants in microRNA target sites
Thomas, Laurent; Saito, Takaya; Sætrom, Pål (Journal article; Peer reviewed, 2011)MicroRNAs (miRNAs) regulate genes post transcription by pairing with messenger RNA (mRNA). Variants such as single nucleotide polymorphisms (SNPs) in miRNA regulatory regions might result in altered protein levels and ...