Blar i NTNU Open på forfatter "Otterlei, Marit"
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Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents
Blindheim, Fredrik Heen; Olsen, Cecilie Elisabeth; Søgaard, Caroline Krogh; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2021)Imidazopyridinones and 7-azaoxindoles are two classes of heterocyclic compounds with only limited previous use in organic and medicinal chemistry. Various synthetic methods and routes have been evaluated to identify safe ... -
Targeted Mass Spectrometric Metabolite Profiling for Studies of Central Carbon Metabolism
Røst, Lisa M. (Doctoral theses at NTNU;2020:194, Doctoral thesis, 2020)Metabolism is the total set of enzymatic reactions occurring in a cell, tissue, organ, or organism to sustain life. It is an implementation of all upstream levels of regulation and environmental stimuli and hence reflecting ... -
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells
Müller, Rebekka; Misund, Kristine; Holien, Toril; Bachke, Siri; Gilljam, Karin Margaretha; Våtsveen, Thea Kristin; Rø, Torstein Baade; Bellacchio, E.; Sundan, Anders; Otterlei, Marit (Journal article; Peer reviewed, 2013)Multiple myeloma is a hematological cancer that is considered incurable despite advances in treatment strategy during the last decade. Therapies targeting single pathways are unlikely to succeed due to the heterogeneous ... -
Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy
Søgaard, Caroline Krogh; Nepal, Anala; Petrovic, Voin; Sharma, Animesh; Liabakk, Nina-Beate; Steigedal, Tonje S.; Otterlei, Marit (Journal article, 2019)Receptor tyrosine kinases (RTKs), such as HER2 and/or EGFR are important therapeutic targets in multiple cancer cells. Low and/or short response to targeted therapies are often due to activation of compensatory signaling ... -
Targeting translesion synthesis by inhibiting protein interactions of the DNA sliding clamps
Ræder, Synnøve Brandt (Doctoral theses at NTNU;2019:354, Doctoral thesis, 2019) -
The APIM-peptide, a novel anti-cancer drug targeting the stress-related roles of PCNA
Søgaard, Caroline Krogh (Doctoral theses at NTNU;2019:186, Doctoral thesis, 2019) -
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans
Olaisen, Camilla; Kvitvang, Hans Fredrik Nyvold; Lee, Sungmin; Almaas, Eivind; Bruheim, Per; Drabløs, Finn; Otterlei, Marit (Journal article; Peer reviewed, 2018)Proliferating cell nuclear antigen (PCNA), a member of the highly conserved DNA sliding clamp family, is an essential protein for cellular processes including DNA replication and repair. A large number of proteins from ... -
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling
Søgaard, Caroline Krogh; Blindheim, Augun; Røst, Lisa Marie; Petrovic, Voin; Nepal, Anala; Bachke, Siri; Liabakk, Nina-Beate; Gederaas, Odrun Arna; Viset, Trond; Arum, Carl-Jørgen; Bruheim, Per; Otterlei, Marit (Journal article; Peer reviewed, 2018)Low response rate and rapid development of resistance against commonly used chemotherapeutic regimes demand new multi-targeting anti-cancer strategies. In this study, we target the stress-related roles of the scaffold ... -
X-ray repair cross complementing protein 1 in base excision repair
Hanssen-Bauer, Audun; Solvang-Garten, Karin; Akbari, Mansour; Otterlei, Marit (Journal article; Peer reviewed, 2012)X-ray Repair Cross Complementing protein 1 (XRCC1) acts as a scaffolding protein in the converging base excision repair (BER) and single strand break repair (SSBR) pathways. XRCC1 also interacts with itself and rapidly ...