• Evaluation of pre-diagnostic blood protein measurements for predicting survival after lung cancer diagnosis 

      Feng, Xiaoshuang; Muller, David C.; Zahed, Hana; Alcala, Karine; Guida, Florence; Smith-Byrne, Karl; Yuan, Jian-Min; Koh, Woon-Puay; Wang, Renwei; Milne, Roger L.; Bassett, Julie K.; Langhammer, Arnulf; Hveem, Kristian; Stevens, Victoria L.; Wang, Ying; Johansson, Mikael; Tjønneland, Anne; Tumino, Rosario; Sheikh, Mahdi; Johansson, Mattias; Robbins, Hilary A. (Peer reviewed; Journal article, 2023)
      Background To evaluate whether circulating proteins are associated with survival after lung cancer diagnosis, and whether they can improve prediction of prognosis. Methods We measured up to 1159 proteins in blood ...
    • External Validation and Recalculation of the CODEX Index in COPD Patients. A 3CIAplus Cohort Study 

      Almagro, Pere; Martínez-Camblor, Pablo; Miravitlles, Marc; Rodríguez-Carballeira, Mónica; Navarro, Annie; Lamprecht, Bernd; Luna, Ana S. Ramirez-Garcia; Kaiser, Bernhard; Alfageme, Inmaculada; Casanova, Ciro; Esteban, Cristobal; Soler-Cataluña, Juan J.; de-Torres, Juan P.; Celli, Bartolome R.; Marin, Jose M.; ter Riet, Gerben; Sobradillo, Patricia; Lange, Peter; Garcia-Aymerich, Judith; Anto, Josep M.; Turner, Alice M.; Han, Meilan K.; Langhammer, Arnulf; Sternberg, Alice; Leivseth, Linda; Bakke, Per S.; Johannessen, Ane; Oga, Toru; Cosío, Borja; Ancochea, Julio; Echazarreta, Andres; Roche, Nicolas; Burgel, Pierre-Régis; Sin, Don D.; Puhan, Milo A.; Soriano, Joan B. (Peer reviewed; Journal article, 2019)
      The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict the risk of death and readmission within one year after discharge. Our study aimed to validate the CODEX index in a large ...
    • Factors associated with vitamin D deficiency in a Norwegian population: the HUNT Study 

      Larose, Tricia L; Chen, Yue; Camargo, Carlos Arthuro; Langhammer, Arnulf; Romundstad, Pål Richard; Mai, Xiao-Mei (Journal article; Peer reviewed, 2014)
      Vitamin D deficiency occurs worldwide. Winter season and high Body Mass Index (BMI) are associated with low levels of serum 25-hydroxyvitamin D (25(OH)D). We estimated the prevalence of vitamin D deficiency in a Norwegian ...
    • General and abdominal obesity and incident asthma in adults: the HUNT study 

      Brumpton, Ben Michael; Langhammer, Arnulf; Romundstad, Pål Richard; Chen, Yue; Mai, Xiao-Mei (Journal article; Peer reviewed, 2013)
      Measures of body mass index (BMI) and waist circumference define general obesity and abdominal obesity respectively. While high BMI has been established as a risk factor for asthma in adults, waist circumference has seldom ...
    • Global Lung Function Initiative 2012 reference equations for spirometry in the Norwegian Population 

      Langhammer, Arnulf; Johannessen, Ane; Holmen, Turid Lingaas; Melbye, Hasse; Stanojevic, Sanja; Lund, May Brit; Melsom, Morten Nissen; Bakke, Per S.; Quanjer, Philip (Journal article; Peer reviewed, 2016)
      We studied the fit of the Global Lung Function Initiative (GLI) all-age reference values to Norwegians, compared them with currently used references (European Community for Steel and Coal (ECSC) and Zapletal) and estimated ...
    • GOLD Classifications, COPD Hospitalization, and All-Cause Mortality in Chronic Obstructive Pulmonary Disease: The HUNT Study 

      Bhatta, Laxmi; Leivseth, Linda; Mai, Xiao-Mei; Henriksen, Anne Hildur; Carslake, David; Chen, Yue; Langhammer, Arnulf; Brumpton, Ben Michael (Peer reviewed; Journal article, 2020)
      Purpose: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published three classifications of COPD from 2007 to 2017. No studies have investigated the ability of these classifications to predict ...
    • Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research 

      Spjuth, Ola; Krestyaninova, Maria; Hastings, Janna; Langhammer, Arnulf; Harris, Jennifer; Shen, Huei-Yi; Heikkinen, Jani; Waldenberger, Melanie; Ladenvall, Claes; Esko, Tõnu; Persson, Mats-Åke; Heggland, Jon; Dietrich, Joern; Ose, Sandra; Gieger, Christian; Ried, Janina S.; Peters, Annette; Fortier, Isabel; de Geus, Eco JC; Klovins, Janis; Zaharenko, Linda; Willemsen, Gonneke; Hottenga, Jouke-Jan; Litton, Jan-Eric; Karvanen, Juha; Boomsma, Dorret I; Groop, Leif; Rung, Johan; Palmgren, Juni; Pedersen, Nancy L; McCarthy, Mark I; van Duijn, Cornelia M; Hveem, Kristian; Metspalu, Andres; Ripatti, Samuli; Prokopenko, Inga (Journal article; Peer reviewed, 2015)
      A wealth of biospecimen samples are stored in modern globally distributed biobanks. Biomedical researchers worldwide need to be able to combine the available resources to improve the power of large-scale studies. A ...
    • Helicobacter pylori in relation to asthma and allergy modified by abdominal obesity: The HUNT study in Norway 

      Ness-Jensen, Eivind; Langhammer, Arnulf; Hveem, Kristian; Lu, Yunxia (Journal article; Peer reviewed, 2019)
      Objective It is unknown whether the decreasing prevalence of H. pylori infections is associated with the increase in obesity and asthma and allergy. In this study, we assessed if obesity plays an intermediate role between ...
    • The HUNT study: A population-based cohort for genetic research 

      Brumpton, Ben Michael; Graham, Sarah; Surakka, Ida; Skogholt, Anne Heidi; Løset, Mari; Fritsche, Lars G.; Wolford, Brooke; Zhou, Wei; Nielsen, Jonas Bille; Holmen, Oddgeir Lingaas; Gabrielsen, Maiken Elvestad; Thomas, Laurent; Bhatta, Laxmi; Rasheed, Humaira; Zhang, He; Kang, Hyun Min; Hornsby, Whitney; Moksnes, Marta Riise; Coward, Eivind; Melbye, Mads; Giskeødegård, Guro F.; Fenstad, Jørn; Krokstad, Steinar; Næss, Marit; Langhammer, Arnulf; Boehnke, Michael; Abecasis, Gonçalo R.; Åsvold, Bjørn Olav; Hveem, Kristian; Willer, Cristen J. (Peer reviewed; Journal article, 2022)
      The Trøndelag Health Study (HUNT) is a population-based cohort of ∼229,000 individuals recruited in four waves beginning in 1984 in Trøndelag County, Norway. Approximately 88,000 of these individuals have available genetic ...
    • Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study 

      Grahnemo, Louise; Nethander, Maria; Coward, Eivind; Gabrielsen, Maiken Elvestad; Sree, Satya; Billod, Jean-Marc; Sjögren, Klara; Engstrand, Lars; Dekkers, Koen F.; Fall, Tove; Langhammer, Arnulf; Hveem, Kristian; Ohlsson, Claes (Peer reviewed; Journal article, 2023)
      Appendicular lean mass (ALM) associates with mobility and bone mineral density (BMD). While associations between gut microbiota composition and ALM have been reported, previous studies rely on relatively small sample sizes. ...
    • Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study) 

      Hellevik, Alf Inge; Johnsen, Marianne Bakke; Langhammer, Arnulf; Fenstad, Anne Marie; Furnes, Ove; Storheim, Kjersti; Zwart, John-Anker; Flugsrud, Gunnar B; Nordsletten, Lars (Journal article; Peer reviewed, 2017)
      Background To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis. Methods In a prospective cohort study, data from the second and third survey of the ...
    • Intake of multivitamin supplements and incident asthma in Norwegian adults: the HUNT study 

      Jiang, Lin; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Mai, Xiao-Mei (Journal article; Peer reviewed, 2015)
      Although intake of multivitamin supplements is becoming increasingly popular, the relationship between intake of multivitamin supplements and incident asthma remains unclear. Prospective studies in adults with long-term ...
    • Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium 

      Skaaby, Tea; Taylor, Amy E; Jacobsen, Rikke K.; Paternoster, Lavinia; Thuesen, Betina H.; Ahluwalia, Tarunveer S.; Larsen, Sofus C.; Zhou, Ang; Wong, Andrew; Gabrielsen, Maiken Elvestad; Bjørngaard, Johan Håkon; Flexeder, Claudia; Männistö, Satu; Hardy, Rebecca; Kuh, Diana; Barry, Sarah J.; Møllehave, Line Tang; Cerqueira, Charlotte; Friedrich, Nele; Bonten, Tobias N.; Noordam, Raymond; Mook-Kanamori, Dennis O.; Taube, Christian; Jessen, Leon E.; McConnachie, Alex; Sattar, Naveed; Upton, Mark N.; McSharry, Charles; Bønnelykke, Klaus; Bisgaard, Hans; Schulz, Holger; Strauch, Konstantin; Meitinger, Thomas; Peters, Annette; Grallert, Harald; Nohr, Ellen A.; Kivimäki, Mika; Kumari, Meena; Völker, Uwe; Nauck, Matthias; Völzke, Henry; Power, Chris; Hyppönen, Elina; Hansen, Torben; Jørgensen, Torben; Pedersen, Oluf; Salomaa, Veikko; Grarup, Niels; Langhammer, Arnulf; Romundstad, Pål Richard; Skorpen, Frank; Kaprio, Jaakko; Munafò, Marcus R.; Linneberg, Allan (Journal article; Peer reviewed, 2017)
      Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic ...
    • Is reduction in lung function associated with reduction in bone mineral density? The HUNT Study. 

      Vadset, Marianne Bjørnland (Master thesis, 2021)
      SAMMENDRAG Bakgrunn: Osteoporose er en vanlig komorbiditet ved kronisk obstruktiv lungesykdom (KOLS), og begge sykdommene har mange nye tilfeller årlig over hele verden. Osteoporose er assosiert med økt mortalitet og ...
    • Is the Disease Burden from COPD in Norway Falling off? A Study of Time Trends in Three Different Data Sources 

      Melbye, Hasse; Helgeland, Jon; Karlstad, Øystein; Ariansen, Inger; Langhammer, Arnulf; Wisløff, Torbjørn; Nafstad, Per; Nystad, Wenche (Peer reviewed; Journal article, 2020)
      Background: Less smoking should lead to fewer COPD cases. We aimed at estimating time trends in the prevalence and burden of COPD in Norway from 2001 to 2017. Methods: We used pre-bronchodilator spirometry and other health ...
    • Is there an association between disease ignorance and self-rated health? The HUNT Study, a cross-sectional survey 

      Jørgensen, Pål; Langhammer, Arnulf; Krokstad, Steinar; Forsmo, Siri (Journal article; Peer reviewed, 2014)
      Objective: To explore whether awareness versus unawareness of thyroid dysfunction, diabetes mellitus or hypertension is associated with self-rated health. Design: Large-scale, cross-sectional population-based study. ...
    • Is there an Association between vitamin D status and risk of chronic low bak pain? A nested case-Control analysis in the Nord-Trøndelag Health Study 

      HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Mai, Xiao-Mei; Langhammer, Arnulf; Zwart, John-Anker (Journal article; Peer reviewed, 2017)
      Objectives: To explore potential associations between vitamin D status and risk of chronic low back pain (LBP) in a Norwegian cohort, and to investigate whether relationships depend on the season of blood sample collection. ...
    • Large-scale external validation and comparison of prognostic models: An application to chronic obstructive pulmonary disease 

      Guerra, Beniamino; Haile, Sarah R.; Lamprecht, Bernd; Ramírez, Ana S.; Martinez-Camblor, Pablo; Kaiser, Bernhard; Alfageme, Inmaculada; Almagro, Pere; Casanova, Ciro; Esteban-González, Cristóbal; Soler-Cataluña, Juan J.; de-Torres, Juan P.; Miravitlles, Marc; Celli, Bartolomé R.; Marin, Jose M.; ter Riet, Gerben; Sobradillo, Patricia; Lange, Peter; Garcia-Aymerich, Judith; Antó, Jósep Maria; Turner, Alice M.; Han, Meilan K.; Langhammer, Arnulf; Leivseth, Linda; Bakke, Per S.; Johannessen, Ane; Oga, Toru; Cosio, Borja; Ancochea-Bermúdez, Julio; Echazarreta, Andrés; Roche, Nicolas; Burgel, Pierre-Régis; Sin, Don D.; Soriano, Joan B.; Puhan, Milo A. (Journal article; Peer reviewed, 2018)
      Background External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease ...
    • Leisure time physical activity and the risk of hip or knee replacement due to primary osteoarthritis: A population based cohort study (The HUNT Study) 

      Johnsen, Marianne Bakke; Hellevik, Alf Inge; Baste, Valborg; Furnes, Ove; Langhammer, Arnulf; Flugsrud, Gunnar B; Nordsletten, Lars; Zwart, John-Anker; Storheim, Kjersti (Journal article; Peer reviewed, 2016)
      Background The relationship between leisure time physical activity (LPA) and hip and knee OA and subsequent joint replacement has not yet been clearly defined. Some studies have found the risk of knee replacement (TKR) to ...
    • Long-term therapy in COPD: Any evidence of adverse effect on bone? 

      Langhammer, Arnulf; Forsmo, Siri; Syversen, Unni (Journal article; Peer reviewed, 2009)
      Patients with COPD have high risk for osteoporosis and fractures. Hip and vertebral fractures might impair mobility, and vertebral fractures further reduce lung function. This review discusses the evidence of bone loss due ...