Blar i NTNU Open på forfatter "Sundan, Anders"
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Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells
Aass, Kristin Roseth; Mjelle, Robin; Kastnes, Martin Haugrud; Tryggestad, Synne Stokke; van den Brink, Luca M; Roseth, Ingrid Aass; Westhrin, Marita; Zahoor, Muhammad; Moen, Siv Helen; Nedal, Tonje Marie Vikene; Buene, Glenn; Misund, Kristine; Sponaas, Anne-Marit; Ma, Qianli; Sundan, Anders; Groen, Richard WJ; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese (Journal article; Peer reviewed, 2021)Interleukin-32 (IL-32) is a nonclassical cytokine expressed in cancers, inflammatory diseases, and infections. Its expression is regulated by two different oxygen sensing systems; HIF1α and cysteamine dioxygenase (ADO), ... -
Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells.
Zub, Kamila Anna; Sousa, Mirta; Sarno, Antonio; Sharma, Animesh; Demirovic, Aida; Rao, Shalini; Young, Clifford; Aas, Per Arne; Ericsson, Ida; Sundan, Anders; Jensen, Ole Nørregaard; Slupphaug, Geir (Journal article; Peer reviewed, 2015)Alkylating agents are widely used chemotherapeutics in the treatment of many cancers, including leukemia, lymphoma, multiple myeloma, sarcoma, lung, breast and ovarian cancer. Melphalan is the most commonly used chemotherapeutic ... -
Monitoring multiple myeloma by quantification of recurrent mutations in serum
Rustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese; Børset, Magne; Beisvag, Vidar; Myklebost, Ola; Meza, Leonardo Zepeda; Hong, Yan Dai; Sundan, Anders; Waage, Anders (Journal article; Peer reviewed, 2017)Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple myeloma patients and its relation to disease activity during long-term ... -
Multiple Myeloma-study of cellular sensitivity to proteasome inhibitors
Baranowska, Katarzyna Anna (Doctoral theses at NTNU;2018:273, Doctoral thesis, 2018)Myelomatose (benmargskreft) – en studie av kreftcellenes følsomhet for kreftmedisiner i gruppen proteasomhemmere Myelomatose er en kreftform som utvikler seg i beinmargen og karakteriseres av ukontrollert vekst av de ... -
MYC amplifications in myeloma cell lines; correlation with MYC-inhibitor efficacy
Holien, Toril; Misund, Kristine; Olsen, Oddrun Elise; Baranowska, Katarzyna Anna; Buene, Glenn; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2015)In multiple myeloma, elevated MYC expression is related to disease initiation and progression. We found that in myeloma cell lines, MYC gene amplifications were common and correlated with MYC mRNA and protein. In primary ... -
Myeloma-derived extracellular vesicles mediate HGF/c-Met signaling in osteoblast-like cells
Strømme, Olaf; Psonka Antonczyk, Katarzyna Maria; Stokke, Bjørn Torger; Sundan, Anders; Arum, Carl-Jørgen; Brede, Gaute (Journal article; Peer reviewed, 2019)Multiple myeloma is an incurable cancer of antibody-producing plasma cells. Hepatocyte growth factor (HGF), a cytokine aberrantly expressed in half of myeloma patients, is involved in myeloma pathogenesis by enhancing ... -
PDL1 expression on plasma and dendritic cells in myeloma bone marrow suggests benefit of targeted anti PD1-PDL1 therapy
Sponaas, Anne-Marit; Nejati Moharrami, Neda; Feyzi, Emadoldin; Standal, Therese; Rustad, Even Holth; Waage, Anders; Sundan, Anders (Peer reviewed; Journal article, 2015)In this study we set out to investigate whether anti PDL1 or PD–1 treatment targeting the immune system could be used against multiple myeloma. DCs are important in regulating T cell responses against tumors. We therefore ... -
Perturbation of the c-Myc-Max Protein-Protein Interaction via Synthetic α-Helix Mimetics
Jung, Kwan-Young; Wang, Huabo; Teriete, Peter; Yap, Jeremy L; Chen, Lijia; Lanning, Maryanna E; Hu, Angela; Lambert, Lester J; Holien, Toril; Sundan, Anders; Cosford, Nicholas D P; Prochownik, Edward V; Fletcher, Steven (Journal article; Peer reviewed, 2015)The rational design of inhibitors of the bHLH-ZIP oncoprotein c-Myc is hampered by a lack of structure in its monomeric state. We describe herein the design of novel, low-molecular-weight, synthetic α-helix mimetics that ... -
Receptor binding competition: A paradigm for regulating TGF-β family action
Martinez-Hackert, Erik; Sundan, Anders; Holien, Toril (Peer reviewed; Journal article, 2020)The transforming growth factor (TGF)-β family is a group of structurally related, multifunctional growth factors, or ligands that are crucially involved in the development, regulation, and maintenance of animal tissues. ... -
Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells
Müller, Rebekka; Misund, Kristine; Holien, Toril; Bachke, Siri; Gilljam, Karin Margaretha; Våtsveen, Thea Kristin; Rø, Torstein Baade; Bellacchio, E.; Sundan, Anders; Otterlei, Marit (Journal article; Peer reviewed, 2013)Multiple myeloma is a hematological cancer that is considered incurable despite advances in treatment strategy during the last decade. Therapies targeting single pathways are unlikely to succeed due to the heterogeneous ... -
TGF-β contamination of purified recombinant GDF15
Olsen, Oddrun Elise; Skjærvik, Anette; Størdal, Berit Fladvad; Sundan, Anders; Holien, Toril (Journal article; Peer reviewed, 2017)Purified recombinant proteins for use in biomedical research are invaluable to investigate protein function. However, purity varies in protein batches made in mammalian expression systems, such as CHO-cells or HEK293-cells. ... -
The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM
Follin-Arbelet, Virginie; Misund, Kristine; Naderi, Elin Hallan; Ugland, Hege Katrin; Sundan, Anders; Blomhoff, Heidi Kiil (Journal article; Peer reviewed, 2015)We have previously demonstrated that activation of the cyclic adenosine monophosphate (cAMP) pathway kills multiple myeloma (MM) cells both in vitro and in vivo. In the present study we have investigated the potential of ... -
The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma
Sponaas, Anne-Marit; Moen, Siv Helen; Liabakk, Nina-Beate; Feyzi, Emadoldin; Holien, Toril; Kvam, Solveig; Grøseth, Lill Anny Gunnes; Størdal, Berit Fladvad; Buene, Glenn; Espevik, Terje; Waage, Anders; Standal, Therese; Sundan, Anders (Journal article; Peer reviewed, 2015)Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages in the bone marrow milieu are important for tumor growth ... -
The role of BMP receptor ALK2 in myeloma cells
Olsen, Oddrun Elise (Doctoral theses at NTNU;2017:65, Doctoral thesis, 2017)ROLLEN TIL BMP-RESEPTOR ALK2 I MYELOMCELLER Myelomgruppa ved Institutt for Kreftforskning og Molekylærmedisin ved NTNU i Trondheim har i mange år arbeidet med myelomatose. Myelomatose, også kjent som beinmargskreft, er ... -
The role of bone morphogenetic proteins in myeloma cell survival
Holien, Toril; Sundan, Anders (Journal article; Peer reviewed, 2014)Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied by osteolytic bone disease due to a disturbed balance between osteoblasts ... -
Validation of Housekeeping Genes for the Use as Endogenous Controls in Real-Time PCR in Multiple Myeloma
Hossain, Md. Sabbir (Master thesis, 2012)Multiple myeloma (MM) is a cancer of malignant plasma cells in the bone marrow, and leads to the development of one or more clinical manifestations such as bone destruction, anaemia, and renal insufficiency. The analysis ... -
Why do myeloma patients have bone disease? A historical perspective.
Børset, Magne; Sundan, Anders; Waage, Anders; Standal, Therese (Peer reviewed; Journal article, 2019)The question of how myeloma cells cause destruction of skeletal tissue has interested scientists for many years, and knowledge in this field has developed in parallel with the understanding of physiological bone remodeling. ...