Browsing NTNU Open by Author "Sandvig, Ioanna"
Now showing items 1-20 of 63
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Adapting Advanced Cellular Models to Patient-Specific Cells for Studying Neurodegenerative Disease
Grønlie, Marthe Bendiksvoll (Master thesis, 2023)Mangelen på en kur for nevrodegenerative sykdommer som amyotrofisk lateral sklerose (ALS) stammer delvis fra mislykkede forsøk på overføring av potensielle medisiner fra dyremodeller til pasienter. I tillegg gjør de genetiske ... -
Advanced cellular models for the recapitulation and study of neuropathology
Bauer, Ulrich Stefan (Doctoral theses at NTNU;2022:225, Doctoral thesis, 2022) -
Advanced neuroengineering for studying the structure-function dynamics in healthy and perturbed neural networks
Malahov, Polina (Master thesis, 2023)The dynamics of the nervous system are characterized by the intricate interactions among precisely arranged multiscale neural networks, arising from the innate capacity of the system for self-organization and adaptation ... -
Alginate modification with the coupling of primary amines relevant for nerve regeneration
Abdoli Najmi, Maryam (Master thesis, 2014)Alginate is a polysaccharide produced by brown seaweed and some bacteria which is highly demanded in biomedical researches. It can form a gel in presence of divalent cations which has many applications in cell based therapy. ... -
Assessment and manipulation of the computational capacity of in vitro neuronal networks through criticality in neuronal avalanches
Heiney, Kristine; Huse Ramstad, Ola; Sandvig, Ioanna; Sandvig, Axel; Nichele, Stefano (Chapter, 2020)In this work, we report the preliminary analysis of the electrophysiological behavior of in vitro neuronal networks to identify when the networks are in a critical state based on the size distribution of network-wide ... -
Brain Development after Neonatal Intermittent Hyperoxia-Hypoxia in the Rat Studied by Longitudinal MRI and Immunohistochemistry
Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Sandvig, Ioanna; Torp, Sverre Helge; Skranes, Jon Sverre; Goa, Pål Erik; Brubakk, Ann-Mari; Widerøe, Marius (Journal article; Peer reviewed, 2013)Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ... -
Bridging the gap between fluid biomarkers for Alzheimer’s disease, model systems, and patients
Bjorkli, Christiana; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2020)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterized by the accumulation of two proteins in fibrillar form: amyloid-β (Aβ) and tau. Despite decades of intensive research, we cannot yet pinpoint ... -
Combinatory strategies for promoting tissue remodelling and endogenous plasticity after experimental ischemic stroke
Augestad, Ingrid Lovise (Doctoral theses at NTNU;2018:145, Doctoral thesis, 2018)Ulike strategier for å fremme regenerering og endogen plastisitet i hjernen etter eksperimentelt iskemisk slag Hjerneslag er på verdensbasis en av sykdommene som rammer flest mennesker i tillegg til å ha høy dødelighet. ... -
Combined targeting of pathways regulating synaptic formation and autophagy attenuates Alzheimer’s disease pathology in mice
Bjorkli, Christiana; Hemler, Mary Elizabeth; Julian, Joshua B; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2022)All drug trials completed to date have fallen short of meeting the clinical endpoint of significantly slowing cognitive decline in Alzheimer’s disease (AD) patients. In this study, we repurposed two FDA-approved drugs, ... -
Connectomics of morphogenetically engineered neurons as a predictor of functional integration in the ischemic brain
Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2019)Recent advances in cell reprogramming technologies enable the in vitro generation of theoretically unlimited numbers of cells, including cells of neural lineage and specific neuronal subtypes from human, including ... -
Controlling the self-assembly and optical properties of gold nanoclusters and gold nanoparticles biomineralized with bovine serum albumin
McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Bandyopadhyay, Sulalit; Lystvet, Sina Maria; Ryan, Joseph Anthony; Volden, Sondre; Kim, Eugene; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm (Journal article; Peer reviewed, 2015)While the size-dependent optical properties of BSA-stabilized gold nanoclusters are well known, the time-dependent growth mechanism remains to be described. Herein, we systematically compare two synthesis methods with and ... -
Criticality as a measure of developing proteinopathy in engineered human neural networks
Valderhaug, Vibeke Devold; Heiney, Kristine; Huse Ramstad, Ola; Bråthen, Geir; Kuan, Wei-Li; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Journal article, 2020)A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases. In Parkinson’s disease (PD), misfolded forms of alpha-synuclein proteins aggregate and accumulate in hallmark ... -
Criticality, Connectivity, and Neural Disorder: A Multifaceted Approach to Neural Computation
Heiney, Kristine; Huse Ramstad, Ola; Fiskum, Vegard; Christiansen, Nicholas; Sandvig, Axel; Nichele, Stefano; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)It has been hypothesized that the brain optimizes its capacity for computation by self-organizing to a critical point. The dynamical state of criticality is achieved by striking a balance such that activity can effectively ... -
Development of a tailored microfluidic platform with improved electrical signal detection for in vitro studies of neural networks and neural network pathology
Winter-Hjelm, Nicolai (Master thesis, 2020)Menneskets nervesystem utgjør verdens mest avanserte evolusjonære maskineri. Gjennom dets høyst intrikate arkitektur og beregningsevner kontrollerer det oppgaver så funksjonelt forskjellige som muskelbevegelser og lagring ... -
Dissecting the complexities of Alzheimer's disease: Engineering selectively vulnerable neural networks in vitro
Hanssen, Katrine Sjaastad (Doctoral theses at NTNU;2023:365, Doctoral thesis, 2023)Alzheimer’s disease (AD) is a progressive, neurodegenerative disease where accumulation of neuropathology can start up to two decades before symptom onset. With no cure for the disease, relevant models of AD are needed to ... -
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice
Hanssen, Katrine Sjaastad; Witter, Menno Peter; Sandvig, Axel; Sandvig, Ioanna; Kobro-Flatmoen, Asgeir (Peer reviewed; Journal article, 2023)Background Primary neuronal cultures enable cell-biological studies of Alzheimer’s disease (AD), albeit typically non-neuron-specific. The first cortical neurons affected in AD reside in layer II of the lateralmost part ... -
Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks
Valderhaug, Vibeke Devold; Heiney, Kristine; Huse Ramstad, Ola; Bråthen, Geir; Kuan, Wei-Li; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases. In Parkinson’s disease (PD), misfolded forms of α-synuclein proteins accumulate in hallmark pathological inclusions ... -
Effects of neural stem cell and olfactory ensheathing cell co-transplants on tissue remodelling after transient focal cerebral ischemia in the adult rat
Augestad, Ingrid Lovise; Nyman, Axel Karl Gottfrid; Costa, Alex Ignatius; Barnett, Susan Carol; Sandvig, Axel; Håberg, Asta; Sandvig, Ioanna (Journal article; Peer reviewed, 2017)Effective transplant-mediated repair of ischemic brain lesions entails extensive tissue remodeling, especially in the ischemic core. Neural stem cells (NSCs) are promising reparative candidates for stroke induced lesions, ... -
Epigenetic modulation of stem cells in neurodevelopment: The role of methylation and acetylation
Podobinska, Martyna; Szablowska-Gadomska, Ilona; Augustyniak, Justyna; Sandvig, Ioanna; Sandvig, Axel; Buzanska, Leonora (Journal article; Peer reviewed, 2017)The coordinated development of the nervous system requires fidelity in the expression of specific genes determining the different neural cell phenotypes. Stem cell fate decisions during neurodevelopment are strictly ... -
Establishing lateral entorhinal cortex layer II-neuron cultures as a tool for the investigation of early Alzheimer's disease related changes
Hanssen, Katrine Sjaastad (Master thesis, 2019)Alzheimer’s disease is a slowly progressing and ultimately fatal neurodegenerative disease affecting more than 46 million people worldwide in 2018. The entorhinal cortex (EC), in particular the layer II of the domains ...