Browsing NTNU Open by Author "Sandvig, Ioanna"
Now showing items 21-40 of 66
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Establishing lateral entorhinal cortex layer II-neuron cultures as a tool for the investigation of early Alzheimer's disease related changes
Hanssen, Katrine Sjaastad (Master thesis, 2019)Alzheimer’s disease is a slowly progressing and ultimately fatal neurodegenerative disease affecting more than 46 million people worldwide in 2018. The entorhinal cortex (EC), in particular the layer II of the domains ... -
EvoDynamic: A Framework for the Evolution of Generally Represented Dynamical Systems and Its Application to Criticality
Pontes-Filho, Sidney; Lind, Pedro; Yazidi, Anis; Zhang, Jianhua; Hammer, Hugo Lewi; Mello, Gustavo; Sandvig, Ioanna; Tufte, Gunnar; Nichele, Stefano (Chapter, 2020)Dynamical systems possess a computational capacity that may be exploited in a reservoir computing paradigm. This paper presents a general representation of dynamical systems which is based on matrix multiplication. That ... -
Extraction and culturing of adult hippocampal and entorhinal neurons from Alzheimer model-animals
Niethammer, Salome Nora (Master thesis, 2022)Abstract will be available on 2027-12-31 -
Formation of neural networks with structural and functional features consistent with small-world network topology on surface-grafted polymer particles
Valderhaug, Vibeke Devold; Glomm, Wilhelm; Sandru, Eugenia Mariana; Yasuda, Masahiro; Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2019)In vitro electrophysiological investigation of neural activity at a network level holds tremendous potential for elucidating underlying features of brain function (and dysfunction). In standard neural network modelling ... -
Generating Neural Networks from Ependymal Cells harvested after Spinal Cord Injury
Rem, Marit Trones (Master thesis, 2020)Traumatisk ryggmargsskader (tRMS) er preget av alvorlige, irreversible forstyrrelser av lokale og nevrale kretsløp i ryggmargen med ødeleggende effekt som når gjennom de supraspinale kanalene. Som svar på tRMS, blir ... -
Growing gold nanostructures for shape-selective cellular uptake
Bandyopadhyay, Sulalit; McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Raghunathan, Karthik; Sandvig, Axel; Sandvig, Ioanna; Andreassen, Jens-Petter; Glomm, Wilhelm (Journal article; Peer reviewed, 2018)With development in the synthesis of shape- and size-dependent gold (Au) nanostructures (NSs) and their applications in nanomedicine, one of the biggest challenges is to understand the interaction of these shapes with ... -
Hallmarks of Criticality in Neuronal Networks Depend on Cell Type and the Temporal Resolution of Neuronal Avalanches
Heiney, Kristine; Valderhaug, Vibeke Devold; Huse Ramstad, Ola; Sandvig, Ioanna; Sandvig, Axel; Nichele, Stefano (Peer reviewed; Journal article, 2021)The human brain has a remarkable capacity for computation, and it has been theorized that this capacity arises from the brain self-organizing into the critical state, a dynamical state poised between ordered and dis- ordered ... -
How does ALS pathology spread to affect healthy neurons? Recapitulation of disease progression in multi-nodal neural networks in vitro
Kollstrøm, Anna Mikalsen (Master thesis, 2020)Amyotrofisk lateral sklerose (ALS) er en nevrodegenerativ sykdom som påvirker øvre og nedre motornevroner, hvilket fører til en gradvis lammelse av muskler og som til slutt resulterer i død på grunn av respirasjonssvikt. ... -
In Vivo Microdialysis in Mice Captures Changes in Alzheimer´s Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology
Bjorkli, Christiana; Louet, Claire; Flo, Trude Helen; Hemler, Mary Elizabeth; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)Background: Preclinical models of Alzheimer’s disease (AD) can provide valuable insights into the onset and progression of the disease, such as changes in concentrations of amyloid-β (Aβ) and tau in cerebrospinal fluid ... -
Increased cost of living - Network scale motor neuron dysfunction in amyotrophic lateral sclerosis
Fiskum, Vegard (Doctoral theses at NTNU;2023:263, Doctoral thesis, 2023)Amyotrofisk lateral sklerose (ALS) er en progressiv nevrodegenerativ sykdom som påvirker motornevroner i det sentrale nervesystemet. Det er den tredje mest vanlige nevrodegenerative sykdommen, med 2 tilfeller per 100 000 ... -
Inhibiting the neuronal region with initial neurodegeneration: effects on neuropathology and behavior
Ebbesen, Nora Cecilie (Master thesis, 2021)Alzheimers sykdom er nevrodegenerativ og progressiv, og den vanligste årsaken til demens. Til tross for at Alzheimers er en økende global helse- og sosioøkonomisk bekymring, er ingen effektiv kur eller behandling tilgjengelig. ... -
The inside-out of Alzheimer’s disease
Bjørkli, Christiana Lucinda (Doctoral theses at NTNU;2022:222, Doctoral thesis, 2022)Every three seconds someone is diagnosed with dementia, and Alzheimer’s disease (AD) constitutes most of these cases. In the absence of a cure for AD, testing hypotheses regarding disease onset and spread, and developing ... -
Interaction of neural stem cells and glial cells with 2D and 3D Matrices
Costa, Alex Ignatius (Master thesis, 2013)Repair of spinal cord or brain injury is a challenge in today?s world as well as the center of attention of neuroscientists. Cell transplantation and in situ tissue engineering are promising approaches for central nervous ... -
Investigating PACMA31 as a Potential Inhibitor for NO-Induced Growth Cone Collapse of In Vitro Neural Networks
Wahlstrøm, Marie (Master thesis, 2024)Hjernen består av nettverk av millioner av nerveceller, koblet sammen av milliarder av synapser. Disse nervene er de grunnleggende byggesteinene i hjernen og er ansvarlige for all informasjonsbehandling via elektriske og ... -
Isolation and comparison of neural stem cells from the adult rat brain and spinal cord canonical neurogenic niches
Schiro, Lars Erik; Bauer, Ulrich Stefan; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2022)Here, we present a unified protocol for the extraction, culture, and basic characterization of rat neural stem cells (NSCs) from all three canonical neurogenic niches in the brain and spinal cord. We describe tissue ... -
L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles
McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Hak, Sjoerd; Bandyopadhyay, Sulalit; Augestad, Ingrid Lovise; Peddis, Davide; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm (Journal article; Peer reviewed, 2016)Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active ... -
Labelling of olfactory ensheathing cells with micron-sized particles of iron oxide and detection by MRI
Sandvig, Ioanna; Hoang, Linh; Sardella, Thomas CP; Barnett, SC; Brekken, Christian; Tvedt, Kåre; Berry, Martin; Haraldseth, Olav; Sandvig, Axel; Thuen, Marte (Journal article; Peer reviewed, 2012)A crucial issue in transplant‐mediated repair of the damaged central nervous system (CNS) is serial non‐invasive imaging of the transplanted cells, which has led to interest in the application of magnetic resonance imaging ... -
Method to Obtain Neuromorphic Reservoir Networks from Images of in Vitro Cortical Networks
Mello, Gustavo; Pontes-Filho, Sidney; Sandvig, Ioanna; Valderhaug, Vibeke Devold; Zouganeli, Evi; Huse Ramstad, Ola; Sandvig, Axel; Nichele, Stefano (Chapter, 2020)In the brain, the structure of a network of neurons defines how these neurons implement the computations that underlie the mind and the behavior of animals and humans. Provided that we can describe the network of neurons ... -
Micro- and mesoscale neuroplasticity of in vitro cortical neuronal networks
Bie, Rikke (Master thesis, 2020)Bakgrunn: Aksonskade er et kjennetegn ved traumatiske skader tilført sentralnervesystemet (CNS). Pasienter lider ofte av langvarige funksjonsnedsettelser som et resultat av den komplekse patofysiologien assosiert med slike ... -
Micro-and mesoscale aspects of neurodegeneration in engineered human neural networks carrying the LRRK2 G2019S mutation
Valderhaug, Vibeke Devold; Ramstad, Ola Huse; van de Wijdeven, Rosanne Francisca; Heiney, Kristine; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2024)Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been widely linked to Parkinson’s disease, where the G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. ...