Blar i NTNU Open på forfatter "Spigset, Olav"
-
Effect of intranasal oxytocin on alcohol withdrawal syndrome: A randomized placebo-controlled double-blind clinical trial
Melby, Katrine; Gråwe, Rolf W.; Aamo, Trond Oskar; Salvesen, Øyvind; Spigset, Olav (Peer reviewed; Journal article, 2019)Background In a pilot study, intranasal oxytocin was demonstrated to reduce the benzodiazepine dose needed to relieve withdrawal symptoms during alcohol detoxification. The aim of the present study was to compare the ... -
The effect of intranasal oxytocin on processing emotional stimuli during alcohol withdrawal: A randomized placebo-controlled double-blind clinical trial
Melby, Katrine; Spigset, Olav; Gråwe, Rolf W.; Aamo, Trond Oskar; Quintana, Daniel (Peer reviewed; Journal article, 2022)Alcohol dependence is associated with difficulties in processing emotional stimuli, which can lead to interpersonal problems. The neuropeptide oxytocin has been shown to modulate the processing of emotional stimuli, however, ... -
Effects of Adrenaline on maternal and fetal fentanyl absorption in epidural analgesia: a randomized trial
Haidl, Frans Felxi; Rosseland, Leiv Arne; Spigset, Olav; Dahl, Vegard (Journal article; Peer reviewed, 2018)Background The combination of low‐dose local anesthesia and lipophilic opioids such as fentanyl is established as a standard solution for labor epidural analgesia. Fentanyl increases efficacy, but may have negative effects ... -
Effects of age and gender on the serum levels of clozapine, olanzapine, risperidone, and quetiapine
Castberg, Ingrid Mehli; Westin, Andreas; Skogvoll, Eirik; Spigset, Olav (Journal article; Peer reviewed, 2017)Objective To investigate serum concentrations of second-generation antipsychotics in relation to age and gender in a population ranging from 18 to 100 years. Method Results from a routine therapeutic drug monitoring ... -
Enantiomeric separation and quantification of citalopram in serum by ultra-high performance supercritical fluid chromatography-tandem mass spectrometry
Hegstad, Solfrid; Havnen, Hilde; Helland, Arne; Falch, Berit Margrethe Hasle; Spigset, Olav (Journal article; Peer reviewed, 2017)A method for enantiomeric separation and quantification of R/S-citalopram in serum was developed and validated using ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS). Sample ... -
EtG and EtS in autopsy blood samples with and without putrefaction using UPLC-MS-MS
Hegstad, Solfrid; Kristoffersen, Lena; Liane, Veronica Horpestad; Spigset, Olav (Journal article; Peer reviewed, 2017)Analytical challenges related to postmortem specimens are well known. The degree of putrefaction of the corpse will influence the quality of the blood samples, and both the efficiency of sample preparation and the subsequent ... -
EtG/EtS in Serum by UHPLC-MS-MS in Suspected Sexual Assault Cases
Hegstad, Solfrid; Helland, Arne; Hagemann, Cecilie Therese; Spigset, Olav (Journal article; Peer reviewed, 2017)A method including semi-automated extraction of ethyl glucuronide (EtG) and ethyl sulfate (EtS) from serum followed by ultra-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS-MS) has been developed and ... -
Examining differences in placental efficiency following exposure to antidepressants and current depression: Findings from an Australian pregnancy cohort study
Galbally, Megan; Watson, Stuart J.; Spigset, Olav; Lappas, Martha; Walker, Susan; Lewis, Andrew J. (Peer reviewed; Journal article, 2022)Introduction Placental dysfunction and inefficiency, is important in understanding fetal growth restriction and low birth weight. Two recent studies have examined the relationship between antidepressant use in pregnancy ... -
Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study
Fjukstad, Katrine Kveli; Athanasiu, Lavinia; Bahrami, Shahram; O`Connell, Kevin; van der Meer, Dennis; Bettella, Francesco; Dieset, Ingrid; Steen, Nils Eiel; Djurovic, Srdjan; Spigset, Olav; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2021)Selective serotonin reuptake inhibitors (SSRIs) are prescribed both to patients with schizophrenia and bipolar disorder. Previous studies have shown associations between SSRI treatment and cardiometabolic alterations. The ... -
Har paracetamol opioidsparende effekt?
Svendson, Isac Fostervoll; Bruheim, Even Jordet (Master thesis, 2021)Bakgrunn: Begrepet «opioidsparende effekt» innebærer at man gir ikke-opioide analgetika i tillegg til opioider i håp om å redusere opioidinntaket og/eller redusere bivirkningene av opioider. Paracetamol er hyppig brukt i ... -
Har paracetamol opioidsparende effekt?
Bruheim, Even Jordet; Svendson, Isac Fostervoll (Master thesis, 2021)Bakgrunn: Begrepet «opioidsparende effekt» innebærer at man gir ikke-opioide analgetika i tillegg til opioider i håp om å redusere opioidinntaket og/eller redusere bivirkningene av opioider. Paracetamol er hyppig brukt i ... -
Hight throughput UHPC-MSMS method for the analysis of phosphatidylethanol (PEth) 16:0/18:1, a specific biomarker for alcohol consumption, in whole blood
Andreassen, Trine Naalsund; Havnen, Hilde; Spigset, Olav; Falch, Berit Margrethe Hasle; Skråstad, Ragnhild Bergene (Journal article; Peer reviewed, 2017)Phosphatidylethanol (PEth) is an alcohol biomarker formed in the presence of ethanol in the body. Both due to its specificity and because it has a detection window of up to several weeks after alcohol intake, its application ... -
Identification of unhealthy alcohol use by self-report and phosphatidylethanol (PEth) blood concentrations in an acute psychiatric department
Finanger, Trine; Vaaler, Arne; Spigset, Olav; Aamo, Trond Oskar; Andreassen, Trine Naalsund; Gråwe, Rolf W.; Skråstad, Ragnhild Bergene (Peer reviewed; Journal article, 2022)Background The use of standard screening methods could improve the detection rate of unhealthy alcohol use in patients admitted to psychiatric acute and emergency departments. The aim of the present study was to investigate ... -
Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study
Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman; Muriq, Hysen; Fosshaug, Linn Elisabeth Lillerud; Spigset, Olav; Øie, Erik (Peer reviewed; Journal article, 2020)Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the ... -
Impact of selective serotonin reuptake inhibitors on cardiometabolic factors in patients with schizophrenia or bipolar disorder
Fjukstad, Katrine Kveli (Doctoral theses at NTNU;2019:208, Doctoral thesis, 2019) -
Implications of psychotropic drug treatment on corrected QT interval in patients diagnosed with an eating disorder.
Øvreness, Thea Emilie (Master thesis, 2023)Bakgrunn: Anorexia nervosa (AN) og bulimia nervosa (BN) er psykiatriske lidelser med potensielt alvorlige psykiatriske og somatiske implikasjoner. De psykiatriske aspektene ved disse komplekse lidelsene har blitt grundig ... -
Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero – the Norwegian Mother and Child Cohort Study
Husebye, Elisabeth Synnøve Nilsen; Gilhus, Nils Erik; Spigset, Olav; Daltveit, Anne Kjersti; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2019)Background and purpose The purpose was to examine the consequences of antiepileptic drug (AED) exposure during pregnancy on language abilities in children aged 5 and 8 years of mothers with epilepsy. Methods The study ... -
Learning the effects of psychotropic drugs during pregnancy using real-world safety data: a paradigm shift toward modern pharmacovigilance
Lupattelli, Angela; Spigset, Olav; Nordeng, Hedvig Marie Egeland (Peer reviewed; Journal article, 2018)The growing evidence on psychotropic drug safety in pregnancy has been possible thanks to the increasing availability of real-world data, i.e. data not collected in conventional randomised controlled trials. Use of these ... -
Legemiddelavvik hos pasienter innlagt i sykehus.
Skeie, Hanne Robbestad; Nordlund, Ragnhild; Slørdal, Lars; Spigset, Olav (Peer reviewed; Journal article, 2021)BAKGRUNN Avvik i bruk og håndtering av legemidler er ikke uvanlig. Det finnes lite oppdatert informasjon om legemiddelavvik i norske sykehus. MATERIALE OG METODE Alle uønskede hendelser ved St. Olavs hospital er pålagt ... -
Legemiddelinteraksjoner hos sykehjemspasienter i Trondheim kommune
Staurset, Hanne Baust; Søraas, Ingvild Aune (Master thesis, 2013)Bakgrunn: Riktig medikamentforskrivning til eldre pasienter på sykehjem er vanskelig. Eldre kan ha endret farmakokinetikk, farmakodynamikk og fysiologi sammenlignet med yngre voksne. Komorbiditet og geriatriske syndrom ...