Blar i NTNU Open på forfatter "Davies, Catharina de Lange"
-
Effect of acoustic radiation force on displacement of nanoparticles in collagen gels
Løvmo, Mia Kvåle; Yemane, Petros Tesfamichael; Bjørkøy, Astrid; Hansen, Rune; Cleveland, Robin O.; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Penetration of nanoscale therapeutic agents into the extracellular matrix (ECM) of a tumor is a limiting factor for the sufficient delivery of drugs in tumors. Ultrasound (US) in combination with microbubbles causing ... -
Effect of Acoustic Radiation Force on the Distribution of Nanoparticles in Solid Tumors.
Afadzi, Mercy; Myhre, Ola Finneng; Yemane, Petros Tesfamichael; Bjørkøy, Astrid; Torp, Sverre Helge; van Wamel, Annemieke; Lelu, Sylvie; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Acoustic radiation force (ARF) might improve the distribution of nanoparticles (NPs) in tumors. To study this, tumors growing subcutaneously in mice were exposed to focused ultrasound (FUS) either 15 min or 4 h after the ... -
Effect of Ultrasound and Microbubble Treatment on Tumor Vasculature and Liposomal Uptake in Murine Cancer Models
Kastellet, Andrea Berge (Master thesis, 2023)Hensikt: Målet med denne oppgaven var å undersøke om ultralyd- og mikroboblebehandling (USMB) kan forbedre levering av nanomedisin i murine tumormodeller. Nærmere bestemt ble effekten av USMB på tumorperfusjon og på opptak ... -
Effect of ultrasound on the distribution of nanoparticles in tumor tissue
Søvik, Kishia Stojcevska (Master thesis, 2013)PC-3 prostate adenocarcinoma cells were injected subcutaneously in the hind leg of female Balb/c nude mice. After a few weeks of tumor growth, 200 $\mu$L of a solution containing gas bubbles stabilized by PBCA nanoparticles ... -
Effect of ultrasound on the vasculature and extravasation of nanoscale particles imaged in real time
Yemane, Petros Tesfamichael; Åslund, Andreas K. O.; Snipstad, Sofie; Bjørkøy, Astrid; Grendstad, Kristin; Berg, Sigrid; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Hansen, Rune; Davies, Catharina de Lange (Journal article; Peer reviewed, 2019)Ultrasound and microbubbles have been found to improve the delivery of drugs and nanoparticles to tumor tissue. To obtain new knowledge on the influence of vascular parameters on extravasation and to elucidate the effect ... -
Effekten av akustisk strålingskraft på levering av nanopartikler til kreftvev
Løvmo, Mia Kvåle (Master thesis, 2016)Ved å innkapsle kjemoterapeutiske agenter i nanopartikler kan behandling av kreft potensielt forbedres, og i kombinasjon med ultralyd kan effekten av en slik behandling økes. Ultralyd kan føre til kavitasjon av gassbobler ... -
Engineering a vascular model based on microfluidics for studying microbubbles in an acoustic field
Li, Ruth Gong (Master thesis, 2018)A major challenge in cancer therapy is the poor and insufficient delivery to tumour sites which many chemotherapeutic drugs face. Ultrasound (US) mediated delivery based on cavitating microbubbles (MBs) has emerged as a ... -
Examining immune responses and nanoparticle uptake in tumors caused by Acoustic Cluster Therapy
Maardalen, Matilde; Vikedal, Krister (Master thesis, 2020) -
Expression of two Cell Membrane Proteins, CD37 and PD-L1, in Acute Myeloid Leukemia Cell Lines
Maaland, Astri Fjelde (Master thesis, 2016)The standard chemotherapy treatment given to newly diagnosed Acute Myeloid Leukemia ( AML ) patients have remained practi- cally the same for the last forty years, and is poorly tolerated by the older patients. Several new ... -
Focused ultrasound and microbubble treatment increases delivery of transferrin receptor-targeting liposomes to the brain
Olsman, Marieke; Sereti, Viktoria; Mühlenpfordt, Melina; Johnsen, Kasper Bendix; Andresen, Thomas Lars; Urquhart, Andrew James; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)The blood-brain barrier (BBB) is a major obstacle to treating several brain disorders. Focused ultrasound (FUS) in combination with intravascular microbubbles increases BBB permeability by opening tight junctions, creating ... -
Identifying Barriers in Extracellular Matrix for Ultrasound-Mediated Delivery of Nanoparticles in 4T1, KPC and CT26 Tumor Models
Wesche, Håkon Fossland (Master thesis, 2023)En av utfordringene ved dagens kreftbehandlinger er at kun en liten del av medisinene akkumuleres i svulsten. Man tror noe av grunnen til dette skyldes at den ekstracellulære matriksen (ECM) i svulstvevet er ekstra tettpakket. ... -
Intracellular Localization of Polymeric Nanoparticles and the Effect of Encapsulated Drug in vitro
Levik, Kjetil Viste (Master thesis, 2015)Chemotherapy could be greatly improved if drug carriers could deliver the chemotherapeutic agents specifically to the cancer cells. SINTEF Materials and Chemistry have developed a novel, multimodal polymeric nanoparticle ... -
Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models
Hyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Davies, Catharina de Lange; Flatmark, Kjersti; Mørch, Ýrr Asbjørg (Peer reviewed; Journal article, 2023)Colorectal and ovarian cancers frequently develop peritoneal metastases with few treatment options. Intraperitoneal chemotherapy has shown promising therapeutic effects, but is limited by rapid drug clearance and systemic ... -
Intraventricular Vector Flow Mapping ― An In Silico and In Vivo Evaluation
Sælensminde, Magnus (Master thesis, 2018)Modern cardiology research aims to encompass sophisticated analysis of intraventricular blood flow in the clinical practice. Such analysis relies on robust and effective means of measuring blood flow fields, an approach ... -
Investigation of Methods for 2D Strain Imaging of Brain Tumors
Kvåle, Kaja Frøysaa (Master thesis, 2014)Intraoperative ultrasound strain imaging displays brain tissue stiffness rather than difference in mass density as regular B-mode imaging. A glioma (the most common type of brain tumor) has a tendency of infiltrating ... -
Mechanical and Acoustic Characterization of Perfluorocarbon Microbubbles Containing Nanoparticles
Moe, Gard Fostad (Master thesis, 2015)In order to optimize the production and behaviour of ultrasound contrast agents it is necessary to map their characteristics. The aim of this master's thesis is to investigate different batches of perfluoropropane microbubbles ... -
Mechanical Properties of Poly(Alkyl Cyanoacrylate) Nanoparticles Measured by Atomic Force Microscopy
Grøneng, Ola Haugen (Master thesis, 2018)With the use of Poly(Alkyl Cyanoacrylate) nanoparticles as drug carriers in ultrasound mediated cancer therapy, it is desirable to know the mechanical properties(Young's Modulus) of the particles to be able to predict their ... -
Mechanisms for delivery of hydrophobic drugs from polymeric nanoparticles to cancer cells
Snipstad, Sofie (Master thesis, 2013)Encapsulation of drugs in nanoparticles could facilitate the accumulation of drugs in the tumor leading to less side effects and improved efficacy of the drug compared to conventional non-specific treatment interventions. ... -
Mechanisms of Cellular Uptake and Intracellular Degradation of Polymeric Nanoparticles
Sulheim, Einar (Master thesis, 2014)The effect of cancer therapy could be greatly improved by encapsulating existing drugs into nanoparticles. Nanoparticles can facilitate delivery of hydrophobic drugs with poor solubility in water, and allow you to target ... -
Metabolic and Histopathological characterization of Prostate cancer
Huynh, Bao-Mai (Master thesis, 2014)Prostatakreft er en av hovedårsakene til kreftrelaterte dødsfall i verden. Fremskritt i kunnskap om denne sykdommen kan bidra til å forbedre utfallet av sykdommen hos pasienter. Biomarkører kan forbedre detekteringen kreften ...