Browsing NTNU Open by Author "Spigset, Olav"
Now showing items 41-60 of 89
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Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study
Lupattelli, Angela; Spigset, Olav; Torgersen, Leila; Zerwas, Stephanie; Hatle, Marianne; Reichborn-Kjennerud, Ted; Bulik, Cynthia M.; Nordeng, Hedvig Marie Egeland (Journal article; Peer reviewed, 2015) -
Medication use in pregnancy: a cross-sectional, multinationalweb-based study
Lupattelli, Angela; Spigset, Olav; Twigg, Michael J.; Zagorodnikova, Ksenia; Mårdby, Ann-Charlotte; Moretti, Myla Emily; Drozd, Mariola; Panchaud, Alice; Hämeen-Anttila, Katri; Rieutord, Andre; Gjergia Jurasky, Romana; Odalovic, Marina; Kennedy, Debra; Rudolf, Gorazd; Juch, Herbert; Passier, Anneke; Björnsdottir, Ingunn; Nordeng, Hedvig Marie Egeland (Journal article; Peer reviewed, 2014)Objectives: Intercountry comparability between studies on medication use in pregnancy is difficult due to dissimilarities in study design and methodology. This study aimed to examine patterns and factors associated with ... -
Metabolite profiling of ortho-, meta- and para-fluorofentanyl by hepatocytes and high-resolution mass spectrometry
Gundersen, Per Ole Mobråten; Åstrand, Anna; Gréen, Henrik; Josefsson, Martin; Spigset, Olav; Vikingsson, Svante (Peer reviewed; Journal article, 2019)New psychoactive substances are emerging on the illegal drug market. Synthetic opioids including fentanyl analogues are of special concern due to their high potency. This indicates the possibility of low drug concentrations ... -
Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications
Chalabianloo, Fatemeh; Fadnes, Lars T.; Johansson, Kjell Arne; Høiseth, Gudrun; Vold, Jørn Henrik; Kringen, Marianne K.; Spigset, Olav; Bramness, Jørgen Gustav (Peer reviewed; Journal article, 2024)Background A considerable inter-individual variability has been reported in the relationship between methadone doses applied and serum concentrations achieved in methadone maintenance treatment. However, the underlying ... -
Metylfenidats kliniske farmakologi
Vagle, Filip; Slettan, Joar (Master thesis, 2016)Bakgrunn: Attention-deficit/hyperactivity disorder/hyperkinetisk forstyrrelse (ADHD/HF) kjennetegnes av konsentrasjonsproblemer, hyperaktivitet og økt impulsivitet. 4,3 % og 1,7 % av henholdsvis gutter og jenter i aldersgruppen ... -
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe; Røyset, Elin Synnøve; Gilde, Bodil; Sandvik, Arne Kristian; Martinsen, Tom Christian; Fossmark, Reidar (Journal article; Peer reviewed, 2019)Background 5‐aminosalicylic acid (5‐ASA) is the first‐line therapy for ulcerative colitis (UC). 5‐ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N‐acetyltransferase (NAT). ... -
Neonatal withdrawal syndrome following in utero exposure to antidepressants: a disproportionality analysis of VigiBase, the WHO spontaneous reporting database.
Gastaldon, Chiara; Arzenton, Elena; Raschi, Emanuel; Spigset, Olav; Papola, Davide; Ostuzzi, Giovanni; Moretti, Ugo; Trifirò, Gianluca; Barbui, Corrado; Schoretsanitis, Georgios (Peer reviewed; Journal article, 2022)Background Evidence on neonatal withdrawal syndrome following antidepressant intrauterine exposure is limited, particularly for antidepressants other than selective serotonin reuptake inhibitor (SSRIs). Methods In ... -
Noncompetitive inhibition of human CYP2C9 in vitro by a commercial Rhodiola rosea product
Thu, Ole Kristian Forstrønen; Spigset, Olav; Hellum, Bent Håvard (Journal article; Peer reviewed, 2017)A commercial Rhodiola rosea (R. rosea) product has previously demonstrated CYP2C9 inhibition in humans. The purpose of this study was to provide in vitro inhibitory data for this particular interaction and to classify the ... -
Nytt verktøy for tolkning av farmakogenetiske analyser
Tuv, Silja Skogstad; Spigset, Olav; Jensen, Elena; Vethe, Nils Tore; Nordal, Kristin (Peer reviewed; Journal article, 2023)Utilgjengelig kunnskap om tolkning av genvarianter som kan påvirke legemiddelrespons, er en barriere for implementering av farmakogenetikk. Vi har utviklet et nettbasert verktøy hvor man kan utføre spørringer og få ... -
Oxytocin treatment in alcohol dependence A double-blind randomized controlled trial
Melby, Katrine (Doctoral theses at NTNU;2020:168, Doctoral thesis, 2020)Nesespray for alkoholavhengighet? Alkohol er det største rusproblemet i Norge og den nest viktigste risikofaktoren for tap av friske leveår i vår del av verden. Det er medisinske utfordringer knyttet til alkoholavhengighet, ... -
Patterns of drug prescriptions in an orthogeriatric ward as compared to orthopaedic ward: results from the Trondheim Hip Fracture Trial - a randomised clinical trial
Heltne, Marianne; Saltvedt, Ingvild; Lydersen, Stian; Prestmo, Anders; Sletvold, Olav; Spigset, Olav (Journal article; Peer reviewed, 2017)Purpose In the Trondheim Hip Fracture Trial, 397 home-dwelling patients with hip fractures were randomised to comprehensive geriatric care (CGC) in a geriatric ward or traditional orthopaedic care (OC). Patients in the ... -
Physiologically-based pharmacokinetic models for CYP1A2 drug-drug interaction prediction: A modeling network of fluvoxamine, theophylline, caffeine, rifampicin, and midazolam
Britz, Hannah; Hanke, Nina; Volz, Anke-Katrin; Spigset, Olav; Schwab, Matthias; Eissing, Thomas; Wendl, Thomas; Frechen, Sebastian; Lehr, Thorsten (Journal article; Peer reviewed, 2019)This study provides whole‐body physiologically‐based pharmacokinetic models of the strong index cytochrome P450 (CYP)1A2 inhibitor and moderate CYP3A4 inhibitor fluvoxamine and of the sensitive CYP1A2 substrate theophylline. ... -
Prenatal Exposure to Non-Steroidal Anti-Inflammatory Drugs and Risk of Attention-Deficit/Hyperactivity Disorder - a Follow-Up Study in the Norwegian Mother, Father and Child Cohort
Andersen, Sarah Hjorth; Lupattelli, Angela; Handal, Marte; Spigset, Olav; Ystrøm, Eivind; Nordeng, Hedvig Marie Egeland (Peer reviewed; Journal article, 2021)Purpose To estimate the association between Attention-Deficit/Hyperactivity Disorder (ADHD) in children in preschool and primary school, and prenatal exposure to non-steroidal anti-inflammatory drugs (NSAIDs) by timing ... -
Quality assessment of structure and language elements of written responses given by seven Scandinavian drug information centres.
Reppe, Linda Amundstuen; Spigset, Olav; Kampmann, Jens Peter; Damkier, Per; Christensen, Hanne Rolighed; Böttiger, Ylva; Schjøtt, Jan (Journal article; Peer reviewed, 2017)Purpose The aim of this study was to identify structure and language elements affecting the quality of responses from Scandinavian drug information centres (DICs). Methods Six different fictitious drug-related queries ... -
Randomized clinical trial of topical tranexamic acid after reduction mammoplasty
Ausen, Kjersti; Fossmark, Reidar; Spigset, Olav; Pleym, Hilde (Journal article; Peer reviewed, 2015)Background The antifibrinolytic drug tranexamic acid is currently being rediscovered for both trauma and major surgery. Intravenous administration reduces the need for blood transfusion and blood loss by about one-third, ... -
Relationship Between Time Consumption and Quality of Responses to Drug-Related Queries:A Study From Seven Drug Information Centers in Scandinavia
Reppe, Linda Amundstuen; Lydersen, Stian; Schjøtt, Jan; Damkier, Per; Christensen, Hanne Rolighed; Kampmann, Jens Peter; Böttiger, Ylva; Spigset, Olav (Journal article; Peer reviewed, 2016)Purpose: The aims of this study were to assess the quality of responses produced by drug information centers (DICs) in Scandinavia, and to study the association between time consumption processing queries and the quality ... -
RESIDUAL CARDIOVASCULAR RISK AFTER ISCHEMIC STROKE Risk factors, medication adherence and risk-benefit considerations
Gynnild, Mari Nordbø (Doctoral theses at NTNU;2022:87, Doctoral thesis, 2022) -
Retrospective screening of synthetic cannabinoids, synthetic opioids and designer benzodiazepines in data files from forensic post mortem samples analyzed by UHLC-QTOF-MS from 2014 to 2018
Gundersen, Per Ole Mobråten; Broecker, Sebastian; Slørdal, Lars; Spigset, Olav; Josefsson, Martin (Peer reviewed; Journal article, 2020)The introduction of new psychoactive substances (NPS) on the illicit drug market has led to major challenges for the analytical laboratories. Keeping screening methods up to date with all relevant drugs is hard to achieve ... -
Risk of preeclampsia after gestational exposure to selective serotonin reuptake inhibitors and other antidepressants: A study from The Norwegian Mother and Child Cohort Study
Lupattelli, Angela; Wood, Mollie; Lapane, Kate L; Spigset, Olav; Nordeng, Hedvig Marie Egeland (Journal article; Peer reviewed, 2017)Purpose To describe the risk of early- and late-onset preeclampsia across pregnancies exposed to antidepressants and to evaluate the impact of timing and length of gestational exposure to antidepressants, particularly ... -
Risk Stratification in Patients with Ischemic Stroke and Residual Cardiovascular Risk with Current Secondary Prevention
Gynnild, Mari Nordbø; Hageman, Steven HJ; Dorresteijn, Jannick AN; Spigset, Olav; Lydersen, Stian; Wethal, Torgeir; Saltvedt, Ingvild; Visseren, Frank LJ; Ellekjær, Hanne (Peer reviewed; Journal article, 2021)Purpose: Suboptimal secondary prevention in patients with stroke causes a remaining cardiovascular risk desirable to reduce. We have validated a prognostic model for secondary preventive settings and estimated future ...