Blar i NTNU Open på forfatter "Spigset, Olav"
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Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition
Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Spigset, Olav (Journal article; Peer reviewed, 2017)Background Pregnancy may cause changes in drug disposition. The clinical consequences may be profound and even counterintuitive; in some cases pregnant women may need more than twice their usual drug dose in order to ... -
Serum Concentrations and Pharmacokinetics of Tranexamic Acid after Two Means of Topical Administration in Massive Weight Loss Skin-Reducing Surgery
Ausen, Kjersti; Pleym, Hilde; Liu, Jiayin; Hegstad, Solfrid; Nordgård, Håvard Bersås; Pavlovic, Ivan; Spigset, Olav (Journal article; Peer reviewed, 2019)Background: Topical administration of tranexamic acid to reduce bleeding is receiving increasing attention, as it is inexpensive, simple, and possibly beneficial in most surgery. Concerns regarding potential systemic adverse ... -
Serum concentrations of mood stabilizers are associated with memory, but not other cognitive domains in psychosis spectrum disorders; explorative analyses in a naturalistic setting
Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen; Nerhus, Mari; Gardsjord, Erlend Strand; Mørch, Ragni Helene; Agartz, Ingrid; Melle, Ingrid; Vaskinn, Anja; Spigset, Olav; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2016)Background Mood stabilizers like lithium and anticonvulsants are used in bipolar and related psychotic disorders. There is a lack of knowledge of the relationship of these medications and cognition in the psychosis ... -
Serum concentrations of paliperidone after administration of the long-acting injectable formulation
Helland, Arne; Spigset, Olav (Journal article; Peer reviewed, 2017)Background: The pharmacokinetics of long-acting intramuscular paliperidone in a naturalistic setting is not well documented. The objective of this study was to investigate the relationship between dose and serum concentrations ... -
Serum or Plasma for Quantification of Direct Oral Anticoagulants?
Aakerøy, Rachel; Stokes, Charlotte Lorentze; Tomic, Marija; Hegstad, Solfrid; Kristoffersen, Ann-Helen; Ellekjær, Hanne; Schjøtt, Jan Didrik; Spigset, Olav; Helland, Arne (Peer reviewed; Journal article, 2022)Background: Direct oral anticoagulants are increasingly replacing vitamin K antagonists for prevention of stroke in patients with atrial fibrillation, partly owing to the lack of a need for routine monitoring. Therapeutic ... -
Sikkerhet ved bruk av langtidsvirkende β₂-agonister ved astma
Solnør, Ludvik Saxhaug; Skeie, Øystein Stenerud; Spigset, Olav; Slørdal, Lars (Peer reviewed; Journal article, 2019)BAKGRUNN Bruk av β-agonister til inhalasjon har siden introduksjonen for mer enn 50 år siden blitt assosiert med økt dødelighet. På 2000-tallet har bekymringene vært spesielt knyttet til langtidsvirkende β2-selektive ... -
Skriftlig legemiddelreklame: Status og utvikling i Norge
Garberg, Hedda Rosland; Gladsø, Kristin Haugen (Master thesis, 2013)Bakgrunn: Markedsføring fra legemiddelindustrien påvirker legers forskriving av medisiner. Det er tidligere vist at kun rundt halvparten av påstandene i skriftlig legemiddelreklame kan klassifiseres som riktig og klinisk ... -
Skriftlig legemiddelreklame: Status og utvikling over to tiår
Almås, Gjermund; Stangebye, Martin (Master thesis, 2024)Bakgrunn: Tidligere studier har satt spørsmålstegn ved kvaliteten på legemiddelreklame som tilsendes allmennlegekontor. Hovedoppgaven er en oppfølger til tidligere undersøkelser, der hensikten er å kartlegge i hvilken grad ... -
Skriftlig legemiddelreklame: Status og utvikling over to tiår
Almås, Gjermund; Stangebye, Martin (Master thesis, 2024)Bakgrunn: Tidligere studier har satt spørsmålstegn ved kvaliteten på legemiddelreklame som tilsendes allmennlegekontor. Hovedoppgaven er en oppfølger til tidligere undersøkelser, der hensikten er å kartlegge i hvilken grad ... -
Stability of Phosphatidylethanol 16:0/18:1 in Freshly Drawn, Authentic Samples from Healthy Volunteers
Skråstad, Ragnhild Bergene; Spigset, Olav; Aamo, Trond Oskar; Andreassen, Trine Naalsund (Peer reviewed; Journal article, 2020)Due to its specificity, phosphatidylethanol (PEth) 16:0/18:1 has gained increased popularity as a marker for high alcohol consumption in recent years. As conflicting results regarding the stability of PEth 16:0/18:1 in ... -
Støtte til fallforebygging hos eldre
Ruths, Sabine; Bakken, Marit Stordal; Ranhoff, Anette Hylen; Granås, Anne Gerd; Spigset, Olav (Journal article; Peer reviewed, 2023) -
Substance use in a psychiatric emergency unit: the effects of motivational interviewing, the course of substance use over 2 years and the reliability of a urine screening test
Bagøien, Gunnhild (Doctoral thesis at NTNU;2016:220, Doctoral thesis, 2016)Summary: Bacground: Among psychiatric patients substance use disorders are associated with increased morbidity and mortality. Use of substances is found to exceed 30 % in the acute psychiatric hospitalizations. In ... -
The effect of antenatal depression and antidepressant treatment on placental tissue: a protein-validated gene expression study
Edvinsson, Åsa; Hellgren, Charlotte; Kallak, Theodora; Åkerud, Helena; Skalkidou, Alkistis; Stener-Victorin, Elisabet; Fornes, Romina; Spigset, Olav; Lager, Susanne; Olivier, Jocelien; Sundström-Poromaa, Inger (Journal article; Peer reviewed, 2019) -
Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants
Eap, C.B.; Gründer, Gerhard; Baumann, P.; Ansermot, N.; Conca, A.; Corruble, E.; Crettol, S.; Dahl, Marja-Liisa; de Leon, Leon; Greiner, C.; Howes, Oliver D.; Kim, E.; Lanzenberger, R.; Meyer, J.H.; Moessner, R.; Mulder, H.; Müller, Daniel J.; Reis, Margareta; Riederer, P.; Ruhe, H.G.; Spigset, Olav; Spina, E.; Stegman, B.; Steimer, W.; Stingl, J.; Suzen, S.; Uchida, H.; Unterecker, S.; Vandenberghe, F.; Hiemke, C. (Peer reviewed; Journal article, 2021)Objectives: More than 40 drugs are available to treat affective disorders. Individual selection of the optimal drug and dose is required to attain the highest possible efficacy and acceptable tolerability for every patient. ... -
Topical moistening of mastectomy wounds with diluted tranexamic acid to reduce bleeding: randomized clinical trial
Ausen, Kjersti; Hagen, Anne Irene; Sæther Østbyhaug, Heidi; Olafsson, Sverrir; Kvalsund, Berit; Spigset, Olav; Pleym, Hilde (Journal article; Peer reviewed, 2019)Background: Topical administration of tranexamic acid (TXA) may be an alternative to intravenous administration to reduce bleeding with a lower risk of systemic adverse events. The aim of this study was to investigate ... -
Topical tranexamic acid to reduce bleeding from surgical wounds
Ausen, Kjersti (Doctoral theses at NTNU;2020:109, Doctoral thesis, 2020) -
Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project
Nordeng, Hedvig Marie Egeland; Wegler, Christine; Lindqvist, Annika; Melander, Erik; Magnusson, Mikaela; Gandia, Peggy; Panchaud, Alice; Baranczewski, Pawel; Spigset, Olav (Peer reviewed; Journal article, 2023)Data on drug transfer into human breast milk are sparse. This study aimed to quantify concentrations of cetirizine and levocetirizine in breast milk and to estimate drug exposure to infants. Breastfeeding women at least ... -
Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding
Amundsen, Siri; Nordeng, Hedvig; Nordeng, Hedvig Marie Egeland; Fuskevåg, Ole Martin; Nordmo, Elisabet; Nordmo, Elisabet N; Sager, Georg; Spigset, Olav (Peer reviewed; Journal article, 2021)Clinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following ... -
Treatment with antipsychotics in pregnancy: changes in drug disposition
Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Castberg, Ingrid Mehli; Spigset, Olav (Journal article; Peer reviewed, 2017)Although pregnancy is known to cause changes in drug pharmacokinetics, little is known about its impact on serum levels of antipsychotics. In this study we retrospectively assessed 201 routine serum antipsychotic therapeutic ... -
Urinary incontinence and drug use: Data from the Norwegian Prescription Database and the HUNT3 study
Mauseth, Siri Ann (Doctoral theses at NTNU;2018:125, Doctoral thesis, 2018)Introduction Urinary incontinence is a common health problem in the female population. The most common drug group used for the treatment of urgency urinary incontinence is anticholinergic drugs, including oxybutynin, ...