dc.contributor.author | Buccino, Federica | |
dc.contributor.author | Zagra, Luigi | |
dc.contributor.author | Longo, Elena | |
dc.contributor.author | D'Amico, Lorenzo | |
dc.contributor.author | Banfi, Giuseppe | |
dc.contributor.author | Berto, Filippo | |
dc.contributor.author | Tromba, Giuliana | |
dc.contributor.author | Vergani, Laura Maria | |
dc.date.accessioned | 2023-10-31T09:19:17Z | |
dc.date.available | 2023-10-31T09:19:17Z | |
dc.date.created | 2023-06-30T11:30:13Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0264-1275 | |
dc.identifier.uri | https://hdl.handle.net/11250/3099653 | |
dc.description.abstract | While advanced imaging strategies have improved the diagnosis of bone-related pathologies, early signs of bone alterations remain difficult to detect. The Covid-19 pandemic has brought attention to the need for a better understanding of bone micro-scale toughening and weakening phenomena. This study used an artificial intelligence-based tool to automatically investigate and validate four clinical hypotheses by examining osteocyte lacunae on a large scale with synchrotron image-guided failure assessment. The findings indicate that trabecular bone features exhibit intrinsic variability related to external loading, micro-scale bone characteristics affect fracture initiation and propagation, osteoporosis signs can be detected at the micro-scale through changes in osteocyte lacunar features, and Covid-19 worsens micro-scale porosities in a statistically significant manner similar to the osteoporotic condition. Incorporating these findings with existing clinical and diagnostic tools could prevent micro-scale damages from progressing into critical fractures. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier B. V. | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing | en_US |
dc.title.alternative | Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.volume | 231 | en_US |
dc.source.journal | Materials & design | en_US |
dc.identifier.doi | 10.1016/j.matdes.2023.112087 | |
dc.identifier.cristin | 2159803 | |
dc.source.articlenumber | 112087 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |