Reducing Palladium leaching in the Suzuki-Miyaura cross-coupling reaction with two magnetic nanoparticle catalysts

Abstract

Denne bacheloroppgaven er en litteraturgjennomgang av Pd-lekkasje i Suzuki-Miyaura reaksjonen (SMC) med to heterogene og magnetiske katalysatorer, katalysator 1 og 2, som var utviklet av Wang et al. Forfatterne målte Pd-lekkasje med spor-analyser, varm-filtreringer og gjenbruks tester. Katalysator 1 og 2 kunne reagere med 4-bromoacetofenon og fenylborsyre med lite Pd-lekkasje og utbytte mellom 96-99%, som vist i Scheme 1. Resirkulerte katalysatorer (etter 21 omganger) kunne vise lignende resultater. Katalysator 2 reagerte bedre enn katalysator 1 med 4-kloracetofenon i Scheme 2 med utbytte på 75% og lite lekkasje. Begge katalysatorer kunne fjernes med magnet.

This thesis is a literature study of Pd-leaching in the Suzuki-Miyaura reaction (SMC) with the two heterogeneous and magnetic catalysts 1 and 2 developed by Wang et al. The authors measured Pd-leaching with trace-analysis, a hot-filtration test and a reusability test. Catalyst 1 and 2 could react with 4-bromoacetophenone and phenylboronic acid with little leaching and yields between 96-99%, shown in Scheme 1. Recycled catalysts (after 21 runs) afforded similar results. Catalyst 2 reacted better than catalyst 1 with 4-chloroacetophenone in Scheme 2 with yields reaching 75% and little leaching. Both catalysts could be removed with an external magnet.