dc.contributor.author | Wang, Gang | |
dc.contributor.author | Hallberg, Jenny | |
dc.contributor.author | Charalampopoulos, Dimitrios | |
dc.contributor.author | Sanahuja, Maribel Casas | |
dc.contributor.author | Breyer-Kohansal, Robab | |
dc.contributor.author | Langhammer, Arnulf | |
dc.contributor.author | Granell, Raquel | |
dc.contributor.author | Vonk, Judith M. | |
dc.contributor.author | Mian, Annemiek | |
dc.contributor.author | Olvera, Núria | |
dc.contributor.author | Laustsen, Lisbeth Mølgaard | |
dc.contributor.author | Rönmark, Eva | |
dc.contributor.author | Abellan, Alicia | |
dc.contributor.author | Agusti, Alvar | |
dc.contributor.author | Arshad, Syed Hasan | |
dc.contributor.author | Bergström, Anna | |
dc.contributor.author | Boezen, H. Marike | |
dc.contributor.author | Breyer, Marie-Kathrin | |
dc.contributor.author | Burghuber, Otto | |
dc.contributor.author | Bolund, Anneli Clea | |
dc.contributor.author | Custovic, Adnan | |
dc.contributor.author | Devereux, Graham | |
dc.contributor.author | Donaldson, Gavin C. | |
dc.contributor.author | Duijts, Liesbeth | |
dc.contributor.author | Esplugues, Ana | |
dc.contributor.author | Faner, Rosa | |
dc.contributor.author | Ballester, Ferran | |
dc.contributor.author | Garcia-Aymerich, Judith | |
dc.contributor.author | Gehring, Ulrike | |
dc.contributor.author | Haider, Sadia | |
dc.contributor.author | Hartl, Sylvia | |
dc.contributor.author | Backman, Helena | |
dc.contributor.author | Holloway, John W. | |
dc.contributor.author | Koppelman, Gerard H. | |
dc.contributor.author | Lertxundi, Aitana | |
dc.contributor.author | Holmen, Turid Lingaas | |
dc.contributor.author | Lowe, Lesley | |
dc.contributor.author | Mensink-Bout, Sara M. | |
dc.contributor.author | Murray, Clare S. | |
dc.contributor.author | Roberts, Graham | |
dc.contributor.author | Hedman, Linnea | |
dc.contributor.author | Schlünssen, Vivi | |
dc.contributor.author | Sigsgaard, Torben | |
dc.contributor.author | Simpson, Angela | |
dc.contributor.author | Sunyer, Jordi | |
dc.contributor.author | Torrent, Maties | |
dc.contributor.author | Turner, Stephen | |
dc.contributor.author | Van den Berge, Maarten | |
dc.contributor.author | Vermeulen, Roel | |
dc.contributor.author | Vikjord, Sigrid Anna Aalberg | |
dc.contributor.author | Wedzicha, Jadwiga A. | |
dc.contributor.author | van der Zee, Anke H. Maitland | |
dc.contributor.author | Melén, Erik | |
dc.date.accessioned | 2023-01-12T09:02:04Z | |
dc.date.available | 2023-01-12T09:02:04Z | |
dc.date.created | 2022-02-07T15:32:02Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | European Respiratory Journal Open Research (ERJ Open Research). 2021, 7 (4), . | en_US |
dc.identifier.issn | 2312-0541 | |
dc.identifier.uri | https://hdl.handle.net/11250/3042890 | |
dc.description.abstract | Background The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts. Methods We studied 49 334 participants from 14 population-based cohorts in different age groups (≤10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ≥LLN, and FVC z-score <LLN. Results The prevalence of obstructive and restrictive phenotypes varied from 3.2–10.9% and 1.8–7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14–3.04), preterm birth (aOR=1.84, 1.27–2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01–1.35) and family history of asthma (aOR=1.44, 95% CI 1.25–1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5–25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03–1.06 and aOR=0.81, 95% CI 0.78–0.85, per kg·m−2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46). Conclusion Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes. | en_US |
dc.description.abstract | Background The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts.
Methods We studied 49 334 participants from 14 population-based cohorts in different age groups (≤10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ≥LLN, and FVC z-score <LLN.
Results The prevalence of obstructive and restrictive phenotypes varied from 3.2–10.9% and 1.8–7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14–3.04), preterm birth (aOR=1.84, 1.27–2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01–1.35) and family history of asthma (aOR=1.44, 95% CI 1.25–1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5–25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03–1.06 and aOR=0.81, 95% CI 0.78–0.85, per kg·m−2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46).
Conclusion Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | European Respiratory Society | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | |
dc.title | Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study | en_US |
dc.title.alternative | Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 0 | en_US |
dc.source.volume | 7 | en_US |
dc.source.journal | European Respiratory Journal Open Research (ERJ Open Research) | en_US |
dc.source.issue | 4 | en_US |
dc.identifier.doi | 10.1183/23120541.00457-2021 | |
dc.identifier.cristin | 1998655 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |