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dc.contributor.authorEl-Behairy, Mohammed Farrag
dc.contributor.authorHassan, Rasha M.
dc.contributor.authorSundby, Eirik
dc.date.accessioned2022-10-26T08:17:47Z
dc.date.available2022-10-26T08:17:47Z
dc.date.created2021-12-03T10:46:28Z
dc.date.issued2021
dc.identifier.citationSeparations. 2021, 8 (10), .en_US
dc.identifier.issn2297-8739
dc.identifier.urihttps://hdl.handle.net/11250/3028335
dc.description.abstractCyanoacetamides are vital synthons in synthetic organic chemistry. However, methods to enantiopure cyanoacetamides have not yet been well explored. In this work, the preparation of cyanoacetamide synthons RS-(1a–4a) or methoxyacetamides RS-(1b–4b) in enantiopure/enriched form was investigated. Compounds S-1, S-2, R-1b, R-1a, andR-2b were prepared in enantiopure form (ee > 99%) while compounds S-4, R-2a, and R-4a were achieved in ee 9%, 80%, and 76%, respectively. Many baselines enantioselective HPLC separations of amines 1–4, their cyanoacetamides (1a–4a), and methoxyacetamides (1b–4b) were achieved by utilizing diverse mobile-phase compositions and two cellulose-based CSPs (ODH® and LUX-3® columns). Such enantioselective HPLC separations were used to monitor the lipase-catalyzed kinetic resolution of amines RS-(1–4). View Full-Texten_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleEnantioselective chromatographic separation and lipase catalyzed asymmetric resolution of biologically important chiral aminesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber11en_US
dc.source.volume8en_US
dc.source.journalSeparationsen_US
dc.source.issue10en_US
dc.identifier.doi10.3390/separations8100165
dc.identifier.cristin1964092
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal