dc.contributor.author | El-Behairy, Mohammed Farrag | |
dc.contributor.author | Hassan, Rasha M. | |
dc.contributor.author | Sundby, Eirik | |
dc.date.accessioned | 2022-10-26T08:17:47Z | |
dc.date.available | 2022-10-26T08:17:47Z | |
dc.date.created | 2021-12-03T10:46:28Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Separations. 2021, 8 (10), . | en_US |
dc.identifier.issn | 2297-8739 | |
dc.identifier.uri | https://hdl.handle.net/11250/3028335 | |
dc.description.abstract | Cyanoacetamides are vital synthons in synthetic organic chemistry. However, methods to enantiopure cyanoacetamides have not yet been well explored. In this work, the preparation of cyanoacetamide synthons RS-(1a–4a) or methoxyacetamides RS-(1b–4b) in enantiopure/enriched form was investigated. Compounds S-1, S-2, R-1b, R-1a, andR-2b were prepared in enantiopure form (ee > 99%) while compounds S-4, R-2a, and R-4a were achieved in ee 9%, 80%, and 76%, respectively. Many baselines enantioselective HPLC separations of amines 1–4, their cyanoacetamides (1a–4a), and methoxyacetamides (1b–4b) were achieved by utilizing diverse mobile-phase compositions and two cellulose-based CSPs (ODH® and LUX-3® columns). Such enantioselective HPLC separations were used to monitor the lipase-catalyzed kinetic resolution of amines RS-(1–4). View Full-Text | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Enantioselective chromatographic separation and lipase catalyzed asymmetric resolution of biologically important chiral amines | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 11 | en_US |
dc.source.volume | 8 | en_US |
dc.source.journal | Separations | en_US |
dc.source.issue | 10 | en_US |
dc.identifier.doi | 10.3390/separations8100165 | |
dc.identifier.cristin | 1964092 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |