| dc.contributor.advisor | Simic, Nebojsa | |
| dc.contributor.author | Verkerk, Robin | |
| dc.date.accessioned | 2022-09-22T17:20:23Z | |
| dc.date.available | 2022-09-22T17:20:23Z | |
| dc.date.issued | 2022 | |
| dc.identifier | no.ntnu:inspera:109833984:32513599 | |
| dc.identifier.uri | https://hdl.handle.net/11250/3020778 | |
| dc.description.abstract | Oppgavens mål er å oppklare strukturene til stoffer ekstrahert fra Laportea aestuans, Colocasia esculenta, Xylopia aethiopica and Raphiostylis beninensis, tradisjonelle nigerianske medisinske planter. Motivasjone for dette arbeidet er å assistere i jakten på nye naturlig forekommende stoffer med medisinske effekter, spesielt mulige krefthemmende stoffer. Ved hjelp av NMR-spektroskopi, IR-spektroskopi, og masse-spektroskopi, ble fire strukturer identifisert med en mulig femte som ikke ble fullstendig bekreftet, men som kommer ekstremt godt overens med tidligere rapporterte spektra. De identifiserte strukturene var:
(E)-3-methyl-5-((1R,2S,4aS,8aR)-1,2,4a,5-tetramethyl-7-oxo-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl)pent-2-enoic acid
4,4a,6b,8a,11,11,12b,14a-octamethylicosahydropicen-3(2H)-one
4,4a,6b,8a,11,11,12b,14a-octamethyldocosahydropicen-3-ol
4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-ol
Kaur-16-en-18-oic acid. | |
| dc.description.abstract | This thesis aims to elucidate the structures of compounds extracted from Laportea aestuans, Colocasia esculenta, Xylopia aethiopica and Raphiostylis beninensis, traditional Nigerian medicinal plants. The motivation for this study is assisting in the pursuit of discovering naturally occurring compounds with medicinal application, particularly with respect to possible cytotoxic compounds. With the aid of NMR spectroscopy, IR spectroscopy, and mass spectroscopy, four structures were identified along with a possible fifth that was not fully confirmed, but corresponds extremely well to previously reported spectra. The elucidated compounds were:
(E)-3-methyl-5-((1R,2S,4aS,8aR)-1,2,4a,5-tetramethyl-7-oxo-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl)pent-2-enoic acid
4,4a,6b,8a,11,11,12b,14a-octamethylicosahydropicen-3(2H)-one
4,4a,6b,8a,11,11,12b,14a-octamethyldocosahydropicen-3-ol
4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-
ol
Kaur-16-en-18-oic acid. | |
| dc.language | eng | |
| dc.publisher | NTNU | |
| dc.title | Elucidated structures from traditional Nigerian medicinal plants | |
| dc.type | Master thesis | |
