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dc.contributor.authorBauer, Michael
dc.contributor.authorGlenn, Tasha
dc.contributor.authorAchtyes, Eric D.
dc.contributor.authorAlda, Martin
dc.contributor.authorAgaoglu, Esen
dc.contributor.authorAltınbaş, Kürşat
dc.contributor.authorAndreassen, Ole
dc.contributor.authorAngelopoulos, Elias
dc.contributor.authorArdau, Rafaella
dc.contributor.authorVares, Edgar Arrua
dc.contributor.authorAydin, Memduha
dc.contributor.authorAyhan, Yavuz
dc.contributor.authorBaethg, Christopher
dc.contributor.authorBauer, Rita
dc.contributor.authorBaune, Bernhard T.
dc.contributor.authorBalaban, Ceylan
dc.contributor.authorBecerra‑Palars, Claudia
dc.contributor.authorBehere, Aniruddh P.
dc.contributor.authorBehere, Prakash B.
dc.contributor.authorBelete, Habte
dc.contributor.authorBelete, Tilahun
dc.contributor.authorBelizario, Gabriel Okawa
dc.contributor.authorBellivier, Frank
dc.contributor.authorBelmake, Robert H.
dc.contributor.authorBenedetti, Francesco
dc.contributor.authorBerk, Michael
dc.contributor.authorBersudsky, Yuly
dc.contributor.authorBicakci, Şule
dc.contributor.authorBirabwa‑Oketcho, Harriet
dc.contributor.authorBjella, Thomas
dc.contributor.authorBrady, Conan
dc.contributor.authorCabrera, Jorge
dc.contributor.authorCappucciati, Marco
dc.contributor.authorCastro, Angela Marianne Paredes
dc.contributor.authorChen, Wei‑Ling
dc.contributor.authorCheung, Eric Yat Wo
dc.contributor.authorChiesa, Silvia
dc.contributor.authorCrowe, Marie
dc.contributor.authorCuomo, Alessandro
dc.contributor.authorDallaspezia, Sara
dc.contributor.authorZompo, Maria Del
dc.contributor.authorDesai, Pratikkumar
dc.contributor.authorDodd, Seetal
dc.contributor.authorDonix, Markus
dc.contributor.authorÉtain, Bruno
dc.contributor.authorFagiolini, Andrea
dc.contributor.authorFellendorf, Frederike T.
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMorken, Gunnar
dc.contributor.authorVaaler, Arne
dc.date.accessioned2022-02-10T12:59:21Z
dc.date.available2022-02-10T12:59:21Z
dc.date.created2022-01-20T15:39:11Z
dc.date.issued2021
dc.identifier.citationInternational journal of bipolar disorders. 2021, 9 .en_US
dc.identifier.issn2194-7511
dc.identifier.urihttps://hdl.handle.net/11250/2978256
dc.description.abstractBackground: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun's electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion: A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.en_US
dc.language.isoengen_US
dc.publisherSpringer Openen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleVariations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorderen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber14en_US
dc.source.volume9en_US
dc.source.journalInternational journal of bipolar disordersen_US
dc.identifier.doi10.1186/s40345-021-00231-7
dc.identifier.cristin1986517
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal