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dc.contributor.authorZhang-James, Yanli
dc.contributor.authorHelminen, Emily C.
dc.contributor.authorLiu, Jinru
dc.contributor.authorBusatto, Geraldo F.
dc.contributor.authorCalvo, Anna
dc.contributor.authorCercignani, Mara
dc.contributor.authorChaim-Avancini, Tiffany M.
dc.contributor.authorGabel, Matt C.
dc.contributor.authorHarrison, Neil A.
dc.contributor.authorLazaro, Luisa
dc.contributor.authorLera-Miguel, Sara
dc.contributor.authorLouza, Mario R.
dc.contributor.authorNicolau, Rosa
dc.contributor.authorRosa, Pedro G.
dc.contributor.authorSchulte-Rutte, Martin
dc.contributor.authorZanetti, Marcus V.
dc.contributor.authorAmbrosino, Sara
dc.contributor.authorAsherson, Philip
dc.contributor.authorBanaschewski, Tobias
dc.contributor.authorBaranov, Alexandr
dc.contributor.authorBaumeister, Sarah
dc.contributor.authorBaur-Streubel, Ramona
dc.contributor.authorBellgrove, Mark A.
dc.contributor.authorBiederman, Joseph
dc.contributor.authorBralten, Janita
dc.contributor.authorBramati, Ivanei
dc.contributor.authorBrandeis, Daniel
dc.contributor.authorBrem, Silvia
dc.contributor.authorBuitelaar, Jan K.
dc.contributor.authorCastellanos, Francisco X.
dc.contributor.authorChantiluke, Kaylita C.
dc.contributor.authorChristakou, Anastasia
dc.contributor.authorCoghill, David
dc.contributor.authorConzelmann, Annette
dc.contributor.authorCubillo, Ana
dc.contributor.authorDale, Anders M.
dc.contributor.authorde Zeeuw, Patrick
dc.contributor.authorDoyle, Alysa E.
dc.contributor.authorDurston, Sarah
dc.contributor.authorEarl, Eric A.
dc.contributor.authorEpstein, Jeffery N.
dc.contributor.authorEthofer, Thomas
dc.contributor.authorFair, Damien A.
dc.contributor.authorFallgatter, Andreas J.
dc.contributor.authorFrodl, Thomas
dc.contributor.authorGogberashvili, Tinatin
dc.contributor.authorHaavik, Jan
dc.contributor.authorHartman, Catharina A.
dc.contributor.authorHeslenfeld, Dirk J.
dc.contributor.authorHoekstra, Pieter J.
dc.contributor.authorHohmann, Sarah
dc.contributor.authorHøvik, Marie Farstad
dc.contributor.authorJahanshad, Neda
dc.contributor.authorJernigan, Terry L.
dc.contributor.authorKardatzki, Bernd
dc.contributor.authorKarkashadze, George A.
dc.contributor.authorKelly, Clare
dc.contributor.authorKohls, Gregor
dc.contributor.authorKonrad, Kerstin
dc.contributor.authorKuntsi, Jonna
dc.contributor.authorLesch, Klaus-Peter
dc.contributor.authorLundervold, Astri J.
dc.contributor.authorMalpas, Charles B.
dc.contributor.authorMattos, Paulo
dc.contributor.authorMcCarthy, Hazel
dc.contributor.authorMehta, Mitul A.
dc.contributor.authorNamazova-Baranova, Leyla
dc.contributor.authorNigg, Joel T.
dc.contributor.authorNovotny, Stephanie E.
dc.contributor.authorO’Gorman Tuura, Ruth L.
dc.contributor.authorWeiss, Eileen Oberwelland
dc.contributor.authorOosterlaan, Jaap
dc.contributor.authorOranje, Bob
dc.contributor.authorPaloyelis, Yannis
dc.contributor.authorPauli, Paul
dc.contributor.authorPlessen, Kerstin J.
dc.contributor.authorRamos-Quiroga, Josep Antoni
dc.contributor.authorReif, Andreas
dc.contributor.authorReneman, Liesbeth
dc.contributor.authorRubia, Katya
dc.contributor.authorSchrantee, Anouk
dc.contributor.authorSchwarz, Lena
dc.contributor.authorSchweren, Lizanne J.S.
dc.contributor.authorSeitz, Jochen
dc.contributor.authorShaw, Philip
dc.contributor.authorSilk, Tim J.
dc.contributor.authorSkokauskas, Norbert
dc.contributor.authorVila, Juan Carlos Soliva
dc.contributor.authorStevens, Michael C.
dc.contributor.authorSudre, Gustavo
dc.contributor.authorTamm, Leanne
dc.contributor.authorThompson, Paul M.
dc.contributor.authorTovar-Moll, Fernanda
dc.contributor.authorvan Erp, Theo G.M.
dc.contributor.authorVance, Alasdair
dc.contributor.authorVilarroya, Oscar
dc.contributor.authorVives-Gilabert, Yolanda
dc.contributor.authorvon Polier, Georg G.
dc.contributor.authorWalitza, Susanne
dc.contributor.authorYoncheva, Yuliya N.
dc.contributor.authorZiegler, Georg C.
dc.contributor.authorFranke, Barbara
dc.contributor.authorHoogman, Martine
dc.contributor.authorFaraone, Stephen
dc.date.accessioned2021-11-02T08:00:58Z
dc.date.available2021-11-02T08:00:58Z
dc.date.created2021-05-23T14:13:22Z
dc.date.issued2021
dc.identifier.citationTranslational Psychiatry. 2021, 11:82 1-9.en_US
dc.identifier.issn2158-3188
dc.identifier.urihttps://hdl.handle.net/11250/2827128
dc.description.abstractAttention-deficit/hyperactivity disorder (ADHD) affects 5% of children world-wide. Of these, two-thirds continue to have impairing symptoms of ADHD into adulthood. Although a large literature implicates structural brain differences of the disorder, it is not clear if adults with ADHD have similar neuroanatomical differences as those seen in children with recent reports from the large ENIGMA-ADHD consortium finding structural differences for children but not for adults. This paper uses deep learning neural network classification models to determine if there are neuroanatomical changes in the brains of children with ADHD that are also observed for adult ADHD, and vice versa. We found that structural MRI data can significantly separate ADHD from control participants for both children and adults. Consistent with the prior reports from ENIGMA-ADHD, prediction performance and effect sizes were better for the child than the adult samples. The model trained on adult samples significantly predicted ADHD in the child sample, suggesting that our model learned anatomical features that are common to ADHD in childhood and adulthood. These results support the continuity of ADHD’s brain differences from childhood to adulthood. In addition, our work demonstrates a novel use of neural network classification models to test hypotheses about developmental continuity.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleEvidence for similar structural brain anomalies in youth and adult attention-deficit/hyperactivity disorder: a machine learning analysisen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-9en_US
dc.source.volume11:82en_US
dc.source.journalTranslational Psychiatryen_US
dc.identifier.doi10.1038/s41398-021-01201-4
dc.identifier.cristin1911460
dc.relation.projectEC/H2020/667302en_US
dc.relation.projectEC/FP7/602805en_US
dc.relation.projectEC/H2020/728018en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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