Blar i Publikasjoner fra CRIStin - NTNU på tidsskrift "Wellcome Open Research"

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    • The genome sequence of the grey wolf, Canis lupus Linnaeus 1758 

      Sinding, Mikkel-Holger S.; Gopalakrishnan, Shyam; Raundrup, Katrine; Dalén, Love; Threlfall, Jonathan; Gilbert, Marcus Thomas Pius (Peer reviewed; Journal article, 2021)
      We present a genome assembly from an individual male Canis lupus orion (the grey wolf, subspecies: Greenland wolf; Chordata; Mammalia; Carnivora; Canidae). The genome sequence is 2,447 megabases in span. The majority of ...

    • The genome sequence of the killer whale, Orcinus orca (Linnaeus, 1758) 

      Foote, Andrew; Bunskoek, Paulien; Sanger, Wellcome (Peer reviewed; Journal article, 2022)
      We present a genome assembly from an individual female Orcinus orca (the killer whale; Chordata; Mammalia; Artiodactyla; Delphinidae). The genome sequence is 2.65 gigabases in span. The majority of the assembly (93.76%) ...

    • Mendelian randomization for studying the effects of perturbing drug targets 

      Gill, Dipender; Georgakis, Marios K.; Walker, Venexia M.; Schmidt, Amand F.; Gkatzionis, Apostolos; Freitag, Daniel F.; Finan, Chris; Hingorani, Aroon D.; Howson, Joanna M.M.; Burgess, Stephen; Swerdlow, Daniel I.; Davey Smith, George; Holmes, Michael V.; Dichgans, Martin; Scott, Robert A.; Zheng, Jie; Psaty, Bruce M.; Davies, Neil Martin (Peer reviewed; Journal article, 2021)
      Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that ...

    • Variants associated with HHIP expression have sex-differential effects on lung function 

      Fawcett, Katherine A.; Obeidat, Ma'en; Melbourne, Carl; Shrine, Nick; Guyatt, Anna L.; John, Catherine; Luan, Jian'an; Richmond, Anne; Moksnes, Marta R.; Granell, Raquel; Weiss, Stefan; Imboden, Medea; May-Wilson, Sebastian; Hysi, Pirro; Boutin, Thibaud S.; Portas, Laura; Flexeder, Claudia; Harris, Sarah E.; Wang, Carol A.; Lyytikäinen, Leo-Pekka; Palviainen, Teemu; Foong, Rachel E.; Keidel, Dirk; Minelli, Cosetta; Langenberg, Claudia; Bossé, Yohan; Berge, Maarten Van den; Sin, Don D.; Hao, Ke; Campbell, Archie; Porteous, David; Padmanabhan, Sandosh; Smith, Blair H.; Evans, David M.; Ring, Sue; Langhammer, Arnulf; Hveem, Kristian; Willer, Cristen J.; Ewert, Ralf; Stubbe, Beate; Pirastu, Nicola; Klaric, Lucija; Joshi, Peter K.; Patasova, Karina; Massimo, Mangino; Polasek, Ozren; Starr, John M.; Karrasch, Stefan; Strauch, Konstantin; Meitinger, Thomas; Rudan, Igor; Rantanen, Taina; Pietiläinen, Kirsi; Kähönen, Mika; Raitakari, Olli T.; Hall, GL; Sly, Peter D.; Pennell, CE; Kaprio, Jaakko; Lehtimäki, Terho; Vitart, Veronique; Deary, Ian J.; Jarvis, Deborah; Wilson, JF; Spector, Tim; Probst-Hensch, Nicole; Wareham, Nick; Völzke, Henry; Henderson, John; Strachan, David P.; Brumpton, Ben Michael; Hayward, Caroline; Hall, Ian P.; Tobin, Martin D.; Wain, Louise V. (Peer reviewed; Journal article, 2021)
      Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide ...