Blar i Publikasjoner fra CRIStin - NTNU på tidsskrift "Nature Communications"
Viser treff 81-100 av 174
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Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
(Journal article; Peer reviewed, 2019)Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from ... -
Genome-wide association meta-analysis identifies 29 new acne susceptibility loci
(Peer reviewed; Journal article, 2022)Acne vulgaris is a highly heritable skin disorder that primarily impacts facial skin. Severely inflamed lesions may leave permanent scars that have been associated with long-term psychosocial consequences. Here, we perform ... -
Genome-wide association study identifies multiple risk loci for renal cell carcinoma
(Journal article; Peer reviewed, 2017)Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing ... -
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
(Peer reviewed; Journal article, 2016)Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power ... -
Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth
(Journal article; Peer reviewed, 2019) -
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
(Journal article; Peer reviewed, 2017)Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ... -
The genomic basis of the plant island syndrome in Darwin’s giant daisies
(Peer reviewed; Journal article, 2022)The repeated, rapid and often pronounced patterns of evolutionary divergence observed in insular plants, or the ‘plant island syndrome’, include changes in leaf phenotypes, growth, as well as the acquisition of a perennial ... -
Genomic identification and characterization of the pseudoautosomal region in highly differentiated avian sex chromosomes
(Journal article; Peer reviewed, 2014)The molecular characteristics of the pseudoautosomal region (PAR) of sex chromosomes remain elusive. Despite significant genome-sequencing efforts, the PAR of highly differentiated avian sex chromosomes remains to be ... -
Genomic insights into the conservation status of the world’s last remaining Sumatran rhinoceros populations
(Peer reviewed; Journal article, 2021)Small populations are often exposed to high inbreeding and mutational load that can increase the risk of extinction. The Sumatran rhinoceros was widespread in Southeast Asia, but is now restricted to small and isolated ... -
Genomic insights into the secondary aquatic transition of penguins
(Journal article; Peer reviewed, 2022) -
Glia-neuron interactions underlie state transitions to generalized seizures
(Journal article; Peer reviewed, 2019)Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms ... -
Global plant trait relationships extend to theclimatic extremes of the tundra biome
(Peer reviewed; Journal article, 2020)The majority of variation in six traits critical to the growth, survival and reproduction of plant species is thought to be organised along just two dimensions, corresponding to strategies of plant size and resource ... -
Global scenarios of resource and emission savings from material efficiency in residential buildings and cars
(Peer reviewed; Journal article, 2021)Material production accounts for a quarter of global greenhouse gas (GHG) emissions. Resource-efficiency and circular-economy strategies, both industry and demand-focused, promise emission reductions through reducing ... -
Gold Catalysts Containing Interstitial Carbon Atoms Boost Hydrogenation Activity
(Peer reviewed; Journal article, 2020)Supported gold nanoparticles are emerging catalysts for heterogeneous catalytic reactions, including selective hydrogenation. The traditionally used supports such as silica do not favor the heterolytic dissociation of ... -
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
(Peer reviewed; Journal article, 2020)Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to ... -
High-quality microresonators in the longwave infrared based on native germanium
(Peer reviewed; Journal article, 2022)The longwave infrared (LWIR) region of the spectrum spans 8 to 14 μm and enables high-performance sensing and imaging for detection, ranging, and monitoring. Chip-scale LWIR photonics has enormous potential for real-time ... -
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
(Journal article; Peer reviewed, 2018)Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous ... -
Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study
(Peer reviewed; Journal article, 2023)Appendicular lean mass (ALM) associates with mobility and bone mineral density (BMD). While associations between gut microbiota composition and ALM have been reported, previous studies rely on relatively small sample sizes. ... -
Imaging high-speed friction at the nanometer scale
(Journal article; Peer reviewed, 2016)Friction is a complicated phenomenon involving nonlinear dynamics at different length and time scales. Understanding its microscopic origin requires methods for measuring force on nanometer-scale asperities sliding at ... -
Impact of inherent energy barrier on spin-orbit torques in magnetic-metal/semimetal heterojunctions
(Peer reviewed; Journal article, 2023)Spintronic devices are based on heterojunctions of two materials with different magnetic and electronic properties. Although an energy barrier is naturally formed even at the interface of metallic heterojunctions, its ...