Blar i Publikasjoner fra CRIStin - NTNU på tidsskrift "Nature Communications"
Viser treff 61-80 av 174
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ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine
(Peer reviewed; Journal article, 2020)Recurrent somatic mutations in ETNK1 (Ethanolamine-Kinase-1) were identified in several myeloid malignancies and are responsible for a reduced enzymatic activity. Here, we demonstrate in primary leukemic cells and in cell ... -
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
(Peer reviewed; Journal article, 2023)Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery ... -
Evaluating climate geoengineering proposals in the context of the Paris Agreement temperature goals
(Journal article; Peer reviewed, 2018)Current mitigation efforts and existing future commitments are inadequate to accomplish the Paris Agreement temperature goals. In light of this, research and debate are intensifying on the possibilities of additionally ... -
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
(Journal article; Peer reviewed, 2017)Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like ... -
Exercise training reduces resting heart rate via downregulation of the funny channel HCN4
(Journal article; Peer reviewed, 2014)Endurance athletes exhibit sinus bradycardia, that is a slow resting heart rate, associated with a higher incidence of sinus node (pacemaker) disease and electronic pacemaker implantation. Here we show that training-induced ... -
Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese
(Journal article; Peer reviewed, 2015)Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional ... -
Freezing solute atoms in nanograined aluminum alloys via high-density vacancies
(Peer reviewed; Journal article, 2022)Low-temperature decomposition of supersaturated solid solution into unfavorable intergranular precipitates is a long-standing bottleneck limiting the practical applications of nanograined aluminum alloys that are prepared ... -
Frictional fluid instabilities shaped by viscous forces
(Peer reviewed; Journal article, 2023)Multiphase flows involving granular materials are complex and prone to pattern formation caused by competing mechanical and hydrodynamic interactions. Here we study the interplay between granular bulldozing and the stabilising ... -
Full-field implementation of a perfect eavesdropper on a quantum cryptography system
(Journal article; Peer reviewed, 2011)Quantum key distribution (QKD) allows two remote parties to grow a shared secret key. Its security is founded on the principles of quantum mechanics, but in reality it significantly relies on the physical implementation. ... -
Functional dissection of inherited non-coding variation influencing multiple myeloma risk
(Peer reviewed; Journal article, 2022)Thousands of non-coding variants have been associated with increased risk of human diseases, yet the causal variants and their mechanisms-of-action remain obscure. In an integrative study combining massively parallel ... -
Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features
(Journal article; Peer reviewed, 2017)Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous ... -
The genetic architecture of human brainstem structures and their involvement in common brain disorders
(Peer reviewed; Journal article, 2020)Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ... -
The genetic architecture of human brainstem structures and their involvement in common brain disorders
(Peer reviewed; Journal article, 2020)Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ... -
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
(Peer reviewed; Journal article, 2016)Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular ... -
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
(Peer reviewed; Journal article, 2020)Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these ... -
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
(Journal article; Peer reviewed, 2018)Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve ... -
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
(Peer reviewed; Journal article, 2020)Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate ... -
Genetic similarity between relatives provides evidence on the presence and history of assortative mating
(Journal article; Peer reviewed, 2024)Assortative mating – the non-random mating of individuals with similar traits – is known to increase trait-specific genetic variance and genetic similarity between relatives. However, empirical evidence is limited for many ... -
Genome-culture coevolution drives rapid divergence in the killer whale
(Journal article; Peer reviewed, 2016)Analysing population genomic data from killer whale ecotypes, which we estimate have globally radiated within less than 250,000 years, we show that genetic structuring including the segregation of potentially functional ... -
Genome-wide analysis yields new loci associating with aortic valve stenosis
(Journal article; Peer reviewed, 2018)Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 ...