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dc.contributor.authorReponen, Elina Johanna
dc.contributor.authorDieset, Ingrid
dc.contributor.authorTesli, Martin Steen
dc.contributor.authorMørch, Ragni Helene
dc.contributor.authorAas, Monica
dc.contributor.authorVedal, Trude Seselie Jahr
dc.contributor.authorHaug, Elisabeth
dc.contributor.authorDrange, Ole Kristian
dc.contributor.authorSteen, Nils Eiel
dc.contributor.authorHope, Sigrun
dc.contributor.authorSzabo, Attila
dc.contributor.authorGohar, Sherif Mostafa Mohamed Ahmed
dc.contributor.authorWedervang-Resell, Kirsten
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorMelle, Ingrid
dc.contributor.authorAukrust, Pål
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorUeland, Thor
dc.identifier.citationFrontiers in Psychiatry. 2020, 11 (672), 1-10.en_US
dc.description.abstractBackground: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade inflammation seems to be a possible contributor. Concurrently, systemic inflammation and its interplay with dyslipidemia is a central driver in the pathogenesis of CVD. We hypothesize that evaluation of atherogenic lipid ratios together with inflammatory markers reflecting different inflammatory pathways with relevance for atherogenesis, could give novel information on immune-related mechanisms involved in early CVD risk in patients with psychotic disorders. Methods: As a measure for CVD risk we calculated atherogenic lipid ratios using established sex-specific cut-offs: Total cholesterol/high-density lipoprotein; HDL-c (TC/HDL) and triglyceride/HDL-c (TG/HDL) were evaluated in 571 schizophrenia (SCZ) and 247 bipolar disorder (BD) patients, and in 99 healthy controls (HC). In addition, as a measure of low-grade inflammation, we measured fasting plasma levels of nine stable atherogenic inflammatory markers in patients (SCZ, BD) and in HC. The elevated inflammatory markers and CVD risk in patients, as reflected by TC/HDL and TG/HDL, were further assessed in multivariable analyses adjusting for comorbid cardio-metabolic risk factors. Results: A markedly higher proportion (26%–31%) of patients had increased TC/HDL and TG/HDL ratios compared with HC. Plasma levels of high-sensitivity C-reactive protein (hs-CRP) and myeloperoxidase (MPO) were higher (p<0.05, p<0.001) in patients with psychotic disorders than in HC, and hs-CRP and MPO were independently associated with atherogenic lipid ratios in the multivariable analyses. Conclusions: Our findings suggest that low-grade inflammation and abnormal neutrophil activation may cause increased CVD risk in patients with psychotic disorders. These mechanisms should be further examined to determine the potential for development of novel risk evaluation strategies.en_US
dc.publisherFrontiers Mediaen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleAtherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disordersen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalFrontiers in Psychiatryen_US
dc.description.localcodeCopyright © 2020 Reponen, Dieset, Tesli, Mørch, Aas, Vedal, Haug, Drange, Steen, Hope, Szabo, Gohar, Wedervang-Resell, Djurovic, Melle, Aukrust, Andreassen and Ueland. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US

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