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dc.contributor.authorGrytten, Nina
dc.contributor.authorMyhr, Kjell-Morten
dc.contributor.authorCelius, Elisabeth Gulowsen
dc.contributor.authorBenjaminsen, Espen
dc.contributor.authorKampman, Margitta Theodora
dc.contributor.authorMidgard, Rune
dc.contributor.authorVatne, Anita
dc.contributor.authorAarseth, Jan Harald
dc.contributor.authorRiise, Trond
dc.contributor.authorTorkildsen, Øivind
dc.date.accessioned2020-01-31T10:25:56Z
dc.date.available2020-01-31T10:25:56Z
dc.date.created2019-11-17T12:02:10Z
dc.date.issued2019
dc.identifier.citationMultiple Sclerosis. 2019, 1-12.nb_NO
dc.identifier.issn1352-4585
dc.identifier.urihttp://hdl.handle.net/11250/2639022
dc.description.abstractBackground: Risk of cancer in multiple sclerosis (MS) patients compared to their siblings is unknown. Objective: The objective was to prospectively investigate the risk of cancer among MS patients compared to siblings without MS and to population controls. Methods: We retrieved data on MS patients born between 1930 and 1979 from the Norwegian Multiple Sclerosis Registry and population studies and on cancer diagnosis from the Cancer Registry of Norway. We used adjusted Cox proportional hazard regression to estimate cancer risk among 6883 MS patients, 8918 siblings without MS, and 37,919 population controls. Results: During 65 years of follow-up, cancer risk among MS patients was higher than that among population controls (hazard ratio (HR) = 1.14, 95% confidence interval (CI): 1.05–1.23) in respiratory organs (HR = 1.66, 95% CI: 1.26–2.19), urinary organs (HR = 1.51, 95% CI: 1.12–2.04), and the central nervous system (HR = 1.52, 95% CI: 1.11–2. 09). Siblings had higher risk of hematological cancers compared with MS patients (HR = 1.82, 95% CI: 1.21–2.73) and population controls (HR = 1.72, 95% CI: 1.36–2.18). Conclusion: MS patients were associated with increased risk of cancer compared to population controls. Siblings had increased risk of hematological cancer. This indicates that MS and hematological cancer could share a common etiology.nb_NO
dc.language.isoengnb_NO
dc.publisherSage Publicationsnb_NO
dc.titleRisk of cancer among multiple sclerosis patients, siblings, and population controls: A prospective cohort studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber1-12nb_NO
dc.source.journalMultiple Sclerosisnb_NO
dc.identifier.doi10.1177/1352458519877244
dc.identifier.cristin1748368
dc.description.localcode© 2019. This is the authors' accepted and refereed manuscript to the article. The final authenticated version is available online at: https://doi.org/10.1177/1352458519877244.nb_NO
cristin.unitcode194,65,0,0
cristin.unitnameFakultet for medisin og helsevitenskap
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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