Studies of early retrovirus-host interactions. Viral determinants for pathogenesis and the influence of sex on the susceptibility to Friend murine leukaemia virus infection
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The studies in the present thesis sought to define virus and host factors that can influence on the susceptibility to murine retrovirus infection. In addition, we wanted to study possible correlations between events of early infection and subsequent disease progression. For an extensive discussion of the major findings, the reader is referred to papers I-IV. The following section will give a general discussion concerning 1) some methodological aspects; 2) the course of FIS-2 infection; 3) determinants responsible for erythroleukaemia; 4) determinants responsible for immunosuppression; and, 5) does sex matter?
Has partsDai, HY; Troseth, GI; Gunleksrud, M; Bruland, T; Solberg, LA; Aarseth, H; Kristiansen, LI; Dalen, A. Identification of Genetic Determinants Responsible for the Rapid Immunosuppressive Activity and the Low Leukemogenic Potential of a Variant of Friend Leukemia Virus, FIS-2. Journal of Virology. 72(2): 1244-1251, 1998.
Bruland, T; Dai, HY; Lavik, LAS; Dalen, A. Early dissemination rates of Friend murine leukaemia virus variants correlate with late pathogenesis. Apmis. 110(12): 899, 2002.
Bruland, T; Dai, HY; Lavik, LAS; Kristiansen, LI; Dalen, A. Gender-related differences in susceptibility, early virus dissemination and immunosuppression in mice infected with Friend murine leukaemia virus variant FIS-2. Journal of General Virology. 82(8): 1821-7, 2001.
Bruland, T; Lavik, LAS; Dai, HY; Dalen, A. A glucocorticoid response element in the LTR U3 region of Friend murine leukaemia virus variant FIS-2 enhances virus production in vitro and is a major determinant for sex differences in susceptibility to FIS-2 infection in vivo. Journal of General Virology. 84: 917-923, 2003.
Bruland, T; Lavik, LAS; Dai, HY; Dalen, A. Identification of Friend murine retrovirus-infected immune cells and studies of the effects of sex and steroid hormones in the early phase of infection. APMIS. 111(9): 878, 2003.