• norsk
    • English
  • English 
    • norsk
    • English
  • Login
View Item 
  •   Home
  • Fakultet for naturvitenskap (NV)
  • Institutt for kjemi
  • View Item
  •   Home
  • Fakultet for naturvitenskap (NV)
  • Institutt for kjemi
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Synthesis of Fused Benzene Amphiphiles

Valderhaug, Solveig
Master thesis
View/Open
18950_FULLTEXT.pdf (Locked)
18950_COVER.pdf (Locked)
URI
http://hdl.handle.net/11250/2615661
Date
2018
Metadata
Show full item record
Collections
  • Institutt for kjemi [811]
Abstract
The discovery of antibiotics have made some major advances in treatment of infectious diseases, other medical treatments and surgery. For the past few decades, overuse, inappropriate prescribing and extensive use of antibiotics in agriculture has lead to a proliferation of resistant bacteria. In order to deal with this evolution, new types of antibiotics, as well as a downscaling of the current overuse of existing antibiotics is essential. Antimicrobial peptides are a novel class of antibiotic agents that are promising towards the emerging resistance crisis. They selectively coordinate to the net negatively charged membrane of bacteria and causes membrane disruption through displacement of lipids and alteration of the membrane structure. In order for the microbes to develop resistance they need to change the structural composition of their membranes, which is improbable. The structure of the synthesized target molecules 1a-b, 15a-c and 19c has an amphipathic structure with a hydrophobic part that is connected to a cationic head group by an indene scaffold. A key reaction in the synthetic route of these compounds is the [2+2+2] cycloaddition of 4 and different alkynes 10a-c. The route involves preparation of 10a-c and further functionalization of the diethylester 11 after the [2+2+2] cycloaddition.
Publisher
NTNU

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit
 

 

Browse

ArchiveCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDocument TypesJournalsThis CollectionBy Issue DateAuthorsTitlesSubjectsDocument TypesJournals

My Account

Login

Statistics

View Usage Statistics

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit